DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and AgaP_AGAP002019

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	XP_321036.4	Gene:	AgaP_AGAP002019 / 1281099	VectorBaseID:	AGAP002019	Length:	347	Species:	Anopheles gambiae

Alignment Length:	384	Identity:	80/384 - (20%)
Similarity:	139/384 - (36%)	Gaps:	117/384 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 TFKKHTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGDVLYEITEHKDTVTETHFSHDGVYLAT 145
            |...||..|.|....||..|..:.|.|....:|....|.....|:.||..:::..:|.|...|.|
Mosquito    53 TLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSRLLVT 117

  Fly   146 GDLAGDLFVFKVSEKHDERPILTKIWEYS--------MSDMSWLF---WHRAAHILLAGSDSGEV 199
            ..              |::.:  ||||.|        ....:::|   ::..::::::||....|
Mosquito   118 AS--------------DDKTL--KIWELSSGKCLKTLKGHTNYVFCCNFNPQSNLIVSGSFDESV 166

  Fly   200 FVFRIPSGEC-KILPGQSSRCESGELSGDGKKLFTAYVNGSVKLWDLKSCQVLIDVNESHPMGFG 263
            .::.:.:|:| |.||..|....:...:.||..:.::..:|..::||
Mosquito   167 RIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD------------------- 212

  Fly   264 EITHAVVACERESPFYVCAEASGECSSGKGIRYNTSFHNKTIRKMLFCTNNGPVSTIQSEHGIEC 328
                               .|||:|                 .|.|...:|.|||.::
Mosquito   213 -------------------TASGQC-----------------LKTLIDDDNPPVSFVK------- 234

  Fly   329 LAFAPSSADLKLFACGSLDGRISIWDYAK-SALRTICENP------VPNDAVIRIKWL----NDH 382
              |:|:.   |.....:||..:.:|||:| ..|:|...:.      ..|.:|...||:    .||
Mosquito   235 --FSPNG---KYILAATLDNTLKLWDYSKGKCLKTYTGHRNEKYCIFANFSVTGGKWIVSGSEDH 294

  Fly   383 TILAATSQGNLNAFDARTGILKFTLTGHYYHIYEFVYKPQENLLLT--VSEDNTAKIFK 439
            .:..    .||.:.:     :..||.||...:......|.||::.:  :..|.|.|::|
Mosquito   295 MVYI----WNLQSKE-----IVQTLQGHTDTVLCTACHPTENIIASAALENDKTIKLWK 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	79/382 (21%)
		WD40	<81..441	CDD:225201	80/384 (21%)
		WD40 repeat	89..126	CDD:293791	10/36 (28%)
		WD40 repeat	132..170	CDD:293791	5/37 (14%)
		WD40 repeat	175..213	CDD:293791	7/41 (17%)
		WD40 repeat	220..299	CDD:293791	9/78 (12%)
		WD40 repeat	266..321	CDD:293791	10/54 (19%)
		WD40 repeat	326..365	CDD:293791	11/39 (28%)
		WD40 repeat	373..408	CDD:293791	8/38 (21%)
		WD40 repeat	414..438	CDD:293791	6/25 (24%)
AgaP_AGAP002019	XP_321036.4	WD40	<47..347	CDD:225201	80/384 (21%)
		WD40	50..344	CDD:238121	79/382 (21%)
		WD40 repeat	61..98	CDD:293791	10/36 (28%)
		WD40 repeat	104..140	CDD:293791	10/51 (20%)
		WD40 repeat	145..181	CDD:293791	7/35 (20%)
		WD40 repeat	188..223	CDD:293791	10/89 (11%)
		WD40 repeat	230..266	CDD:293791	13/47 (28%)
		WD40 repeat	274..311	CDD:293791	9/45 (20%)
		WD40 repeat	317..343	CDD:293791	6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010