DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and AgaP_AGAP012029

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	XP_320491.4	Gene:	AgaP_AGAP012029 / 1280633	VectorBaseID:	AGAP012029	Length:	378	Species:	Anopheles gambiae

Alignment Length:	364	Identity:	83/364 - (22%)
Similarity:	116/364 - (31%)	Gaps:	133/364 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 KKHTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGDVLYEITEHKDTVTETHFSHDGVYLATGD 147
            |.|...:...|.:|.....||.|.|..|.||..:..........|.|.|.:..:|.||..::|
Mosquito    11 KGHRGKLTGLSFNPEGTRFVTSSTDHSAIVWTNNEQVRCMRFEAHTDVVNDVCWSPDGRIIST-- 73

  Fly   148 LAGDLFVFKVSEKHDERPILTKIWEYSMSDMSWLFWHRAAHILLAGSDSGEVFVFRIPSGECKIL 212
                     ||:   :|.:  |||..||               |..||.     ||
Mosquito    74 ---------VSK---DRSV--KIWVPSM---------------LGNSDE-----FR--------- 95

  Fly   213 PGQSSRCESGELSGDGKKLFTAYVNGSVKLWDLKSCQVLIDVNESHPMGFGEITHAVVACERESP 277
             |.:|...|.:....||||.||..:.:||||.:...|.|
Mosquito    96 -GHTSNVRSVDFDPTGKKLLTASDDKTVKLWKVSRKQFL-------------------------- 133

  Fly   278 FYVCAEASGECSSGKGIRYNTSFHNKTIRKMLFCTNNGPVSTIQSEHGIECLAFAPSSADLKLFA 342
                                :||...|                   :.:.|..|:|:.   ||.|
Mosquito   134 --------------------SSFTGHT-------------------NWVRCARFSPNG---KLIA 156

  Fly   343 -CGSLDGRISIWDYAKSALRTICENPV--PNDAVIRIKWLNDHTILA-ATSQGNLNAFDARTGIL 403
             ||. |..:.::|.|...    |.:..  ...|..::.|..|.|::| |.....:..||  ..|.
Mosquito   157 SCGD-DRTLKLFDPATGQ----CVHSFYDQKGAGCKVAWHPDSTLVAIALDNCRVKIFD--INIR 214

  Fly   404 KFTLTGHYYHIYE-----FVYKPQENLLLTVSEDNTAKI 437
            |..   .||.||:     ..:.|..|.|:|.|:|...||
Mosquito   215 KLI---QYYRIYDGPVNSLDFHPSGNYLITGSDDGVTKI 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	83/364 (23%)
		WD40	<81..441	CDD:225201	83/364 (23%)
		WD40 repeat	89..126	CDD:293791	9/36 (25%)
		WD40 repeat	132..170	CDD:293791	7/37 (19%)
		WD40 repeat	175..213	CDD:293791	6/37 (16%)
		WD40 repeat	220..299	CDD:293791	13/78 (17%)
		WD40 repeat	266..321	CDD:293791	3/54 (6%)
		WD40 repeat	326..365	CDD:293791	11/39 (28%)
		WD40 repeat	373..408	CDD:293791	9/35 (26%)
		WD40 repeat	414..438	CDD:293791	10/29 (34%)
AgaP_AGAP012029	XP_320491.4	WD40	8..294	CDD:238121	83/364 (23%)
		WD40	10..312	CDD:225201	83/364 (23%)
		WD40 repeat	17..54	CDD:293791	9/36 (25%)
		WD40 repeat	60..96	CDD:293791	17/81 (21%)
		WD40 repeat	101..137	CDD:293791	14/81 (17%)
		WD40 repeat	144..179	CDD:293791	12/42 (29%)
		WD40 repeat	186..219	CDD:293791	9/37 (24%)
		WD40 repeat	227..263	CDD:293791	8/24 (33%)
		WD40 repeat	269..293	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010