DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and AgaP_AGAP009574

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	XP_318586.4	Gene:	AgaP_AGAP009574 / 1278935	VectorBaseID:	AGAP009574	Length:	391	Species:	Anopheles gambiae

Alignment Length:	392	Identity:	85/392 - (21%)
Similarity:	148/392 - (37%)	Gaps:	72/392 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 TFKKHTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGDVLYEITEHKDTVTETHFSHDGVYLAT 145
            |.:.|..|:.......:....:|||.|....:|...:||....:..|::.|....:::...|
Mosquito    39 TLQTHILPLTNVCFDKSGKKCITGSYDRTCRIWNVESGDEEKVLKGHENVVFSVAYNYPRWY--- 100

  Fly   146 GDLAGDLFVFKVSEKHDERPILT-------------KIWEYSMSDMSWLFWHRAAHILLAG---- 193
             |.... .|||: |.....|||:             |||.....:.....|...|.|:.|.
Mosquito   101 -DFKSP-NVFKL-EASPHFPILSSDRILTGSFDKTAKIWNPVSGNCINTLWGHTAEIVGAEFNPH 162

  Fly   194 --------SDSGEVFVFRIPSG-ECKILPGQSSRCESGELSGDGKKLFTAYVNGSVKLWDLKSCQ 249
                    |......||...:| |..:....|:...|...:.:|..|.||..:.:..:||:::.:
Mosquito   163 QCELVATCSMDNTARVFHSETGQEIHLFADHSAEVISARFNKEGSLLLTASFDETATVWDMRAKE 227

  Fly   250 VLIDVNESHPMGFGEITHAVVACERESPFYVCAEASGECSSGKGIRYNTSFHNKT-----IRKML 309
                             ||:|....|      ||.|....:.:.....||..::|     :|::
Mosquito   228 -----------------HAIVIRGHE------AELSNAVWNFQCNLIATSSLDRTAKIWDLRRL- 268

  Fly   310 FCTNNGPVSTIQSEHGIECLAFAPSSADLKLFACGSLDGRISIWDYAKS-ALRTICENPVPNDAV 373
                :.|.:|  :.|..|.|..|.:....:| |.||.|....:||...: .|.||...  .:|.|
Mosquito   269 ----DEPQAT--ATHKDEVLDVAFNCTGTRL-ATGSADCTAKVWDVTGNFELVTIMAG--HSDEV 324

  Fly   374 IRIKWL-NDHTILAATSQGNLNAFDARTGILKFTLTGHYYHIYEFVYKPQENLLLTVSEDNTAKI 437
            .::.:. ....:|.|::......:::.||....||:||...::...:....:.::|.|:|||.||
Mosquito   325 SKVTFSPPGGLLLTASADKTARIWNSGTGTCTQTLSGHDGEVFSCSFNYSGDAIITASKDNTCKI 389

  Fly   438 FK 439
            ::
Mosquito   390 WR 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	85/390 (22%)
		WD40	<81..441	CDD:225201	85/392 (22%)
		WD40 repeat	89..126	CDD:293791	7/36 (19%)
		WD40 repeat	132..170	CDD:293791	9/50 (18%)
		WD40 repeat	175..213	CDD:293791	9/50 (18%)
		WD40 repeat	220..299	CDD:293791	14/78 (18%)
		WD40 repeat	266..321	CDD:293791	13/59 (22%)
		WD40 repeat	326..365	CDD:293791	13/39 (33%)
		WD40 repeat	373..408	CDD:293791	6/35 (17%)
		WD40 repeat	414..438	CDD:293791	6/23 (26%)
AgaP_AGAP009574	XP_318586.4	WD40	19..390	CDD:225201	84/389 (22%)
		WD40	38..72	CDD:197651	7/32 (22%)
		WD40 repeat	48..84	CDD:293791	7/35 (20%)
		WD40	78..391	CDD:238121	75/351 (21%)
		WD40 repeat	155..192	CDD:293791	6/36 (17%)
		WD40 repeat	197..233	CDD:293791	10/52 (19%)
		WD40 repeat	241..274	CDD:293791	5/37 (14%)
		WD40 repeat	281..317	CDD:293791	11/36 (31%)
		WD40 repeat	324..360	CDD:293791	6/35 (17%)
		WD40 repeat	366..390	CDD:293791	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010