DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and AgaP_AGAP007739

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	XP_317781.4	Gene:	AgaP_AGAP007739 / 1278226	VectorBaseID:	AGAP007739	Length:	504	Species:	Anopheles gambiae

Alignment Length:	414	Identity:	83/414 - (20%)
Similarity:	138/414 - (33%)	Gaps:	130/414 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 EELRDRERIAAITDEATVTFKKHTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGD------VL 121
            |.:...:.|.....:||| .:.|.:.||.|:.:|:.:...:||.|..|.:|:.|...      ||
Mosquito   137 ETMEVDQSIEIPASKATV-LRGHESEVFICAWNPSTDLLASGSGDSTARIWDMSDNPANPNQLVL 200

  Fly   122 --------YEITEHKDTVTETHFSHDGVYLATGDLAGDLFVFKVSEKHDERPILTKIWEYSMSDM 178
                    .|:..:|| ||...::.||..||||...|                ..:||
Mosquito   201 RHCIQKGGTEVPSNKD-VTSLDWNCDGTLLATGSYDG----------------YARIW------- 241

  Fly   179 SWLFWHRAAHILLA--GSDSGEVFVFRIPSGECKILPGQSSRCESGELSGDGKKLFTAYVNGSVK 241
                  |...:|.:  |...|.:|..:                    .:..|..:.:|.|:.:..
Mosquito   242 ------RTDGLLASTLGQHKGPIFALK--------------------WNKRGNYILSAGVDKTTI 280

  Fly   242 LWDLKSCQV----------LIDVNESHPMGFGEITHAVVACERESPFYVCAEASGECSSGKGIRY 296
            :||..:.|.          .:||:......|       .:|..:...:||.         .|:
Mosquito   281 IWDAATGQCTQQFSFHSAPALDVDWQSNQSF-------ASCSTDQCIHVCK---------LGV-- 327

  Fly   297 NTSFHNKTIRKMLFCTNNGPVSTIQSEHGIECLAFAPSSADLKLFACGSLDGRISIWDYAKSALR 361
                 :|.|:.....||.           :..:.:.|..   :|.|..|.|..:.||    |..:
Mosquito   328 -----DKPIKSFQGHTNE-----------VNAIKWDPQG---QLLASCSDDMTLKIW----SMKQ 369

  Fly   362 TICENPVP--NDAVIRIKWL---------NDHTILAATS-QGNLNAFDARTGILKFTLTGHYYHI 414
            ..|.:.:.  :..:..|||.         |.:.|||:.| ...:..:|...|:...|||.|...:
Mosquito   370 DTCVHDLQAHSKEIYTIKWSPTGTGTQNPNMNLILASASFDSTVRLWDVERGVCIHTLTKHTEPV 434

  Fly   415 YEFVYKPQENLLLTVSEDNTAKIF 438
            |...:.|....|.:.|.|....|:
Mosquito   435 YSVAFSPDGKFLASGSFDKCVHIW 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	80/398 (20%)
		WD40	<81..441	CDD:225201	78/396 (20%)
		WD40 repeat	89..126	CDD:293791	13/50 (26%)
		WD40 repeat	132..170	CDD:293791	8/37 (22%)
		WD40 repeat	175..213	CDD:293791	5/39 (13%)
		WD40 repeat	220..299	CDD:293791	13/88 (15%)
		WD40 repeat	266..321	CDD:293791	8/54 (15%)
		WD40 repeat	326..365	CDD:293791	8/38 (21%)
		WD40 repeat	373..408	CDD:293791	11/44 (25%)
		WD40 repeat	414..438	CDD:293791	5/23 (22%)
AgaP_AGAP007739	XP_317781.4	LisH	6..32	CDD:285685
		WD40	154..459	CDD:238121	79/397 (20%)
		WD40 repeat	162..206	CDD:293791	12/43 (28%)
		WD40 repeat	218..253	CDD:293791	12/63 (19%)
		WD40 repeat	258..294	CDD:293791	7/55 (13%)
		eIF2A	261..469	CDD:285825	46/259 (18%)
		WD40 repeat	301..335	CDD:293791	9/56 (16%)
		WD40 repeat	341..377	CDD:293791	9/42 (21%)
		WD40 repeat	383..428	CDD:293791	11/44 (25%)
		WD40 repeat	434..458	CDD:293791	5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010