DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and AgaP_AGAP007217

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	XP_308568.4	Gene:	AgaP_AGAP007217 / 1269914	VectorBaseID:	AGAP007217	Length:	504	Species:	Anopheles gambiae

Alignment Length:	446	Identity:	89/446 - (19%)
Similarity:	138/446 - (30%)	Gaps:	166/446 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DELQEIIELEEQP------------LDEDDDDLEEVTLEQLEARLAMAGGDDDEEEDEEELRDRE 69
            ::|:..:.|...|            ||.:..|..::          :.||:|.......  :|.|
Mosquito   202 EKLRGFLTLASHPGLHSASVPGILALDINHSDQSKI----------LTGGNDKNATVFN--KDTE 254

  Fly    70 RIAAITDEATVTFKKHTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGDVLYEITEHKDTVTET 134
            :|.|:       .|.||..|.....||..:..:|||.|....||...|......:..|...||
Mosquito   255 QIVAV-------LKGHTKKVTKVIFHPEEDTVITGSPDCNIRVWHVPTSQTQLLLRCHDGPVT-- 310

  Fly   135 HFSHDGVYLATGDLAGDLFVFKVSEKHDERPILTKIWEYSMSDMSWLFWHRAAHILLAGSDSGEV 199
                 |:.|..   .||..:...|:||         |.:  ||:      |:..:|...:|:.|.
Mosquito   311 -----GLSLHP---TGDYVLSTSSDKH---------WAF--SDI------RSGRLLTKVADTAEY 350

  Fly   200 FVFRIPSGECKILPGQSSRCESGELSGDGKKLFTAYVNGSVKLWDLKSCQVLIDVNESHPMGFGE 264
            .:                  .|.:...||....|...:..||:||||        .:|:...|..
Mosquito   351 GL------------------TSAQFHPDGLIFGTGTEDSQVKIWDLK--------EQSNVANFAG 389

  Fly   265 ITHAVVACE-RESPFYVCAEASGECSSGKGIRYNTSFHNKTIRKMLFCTNNGPVSTIQSEHGIEC 328
            .|..:.|.. .|:.:|:...|...|.....:|...:|                 .|||.:.|.|.
Mosquito   390 HTGPITAISFSENGYYLATAADDACVKLWDLRKLKNF-----------------KTIQLDDGYEV 437

  Fly   329 --LAFAPS-------SADLKLFACGSLDGRISIWDYAKSALRTICENPVPNDAVIRIKWLNDHTI 384
              |.|..|       ..|::::.|..       |.                    .:|..||||.
Mosquito   438 KDLCFDQSGTYLSIAGTDIRVYLCKQ-------WQ--------------------ELKVFNDHTA 475

  Fly   385 LAATSQGNLNAFDARTGILKFTLTGHYYHIYEFVYKPQENLLLTVSEDNTAKIFKV 440
            ||             ||: :|.....|              :.:.|.|.|.|::.:
Mosquito   476 LA-------------TGV-RFGKHAQY--------------IASTSMDRTLKLYGI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	76/369 (21%)
		WD40	<81..441	CDD:225201	76/370 (21%)
		WD40 repeat	89..126	CDD:293791	10/36 (28%)
		WD40 repeat	132..170	CDD:293791	8/37 (22%)
		WD40 repeat	175..213	CDD:293791	6/37 (16%)
		WD40 repeat	220..299	CDD:293791	19/79 (24%)
		WD40 repeat	266..321	CDD:293791	9/55 (16%)
		WD40 repeat	326..365	CDD:293791	7/47 (15%)
		WD40 repeat	373..408	CDD:293791	10/34 (29%)
		WD40 repeat	414..438	CDD:293791	4/23 (17%)
AgaP_AGAP007217	XP_308568.4	Ubox	2..68	CDD:128780
		Prp19	69..132	CDD:285771
		WD40	209..501	CDD:238121	88/435 (20%)
		WD40	<224..504	CDD:225201	86/424 (20%)
		WD40 repeat	224..262	CDD:293791	10/56 (18%)
		WD40 repeat	268..304	CDD:293791	9/35 (26%)
		WD40 repeat	309..345	CDD:293791	14/62 (23%)
		WD40 repeat	353..388	CDD:293791	11/42 (26%)
		WD40 repeat	394..430	CDD:293791	8/52 (15%)
		WD40 repeat	437..483	CDD:293791	15/86 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910