DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and wdr86

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	XP_002932539.2	Gene:	wdr86 / 100486668	XenbaseID:	XB-GENE-981853	Length:	415	Species:	Xenopus tropicalis

Alignment Length:	385	Identity:	80/385 - (20%)
Similarity:	137/385 - (35%)	Gaps:	79/385 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 HTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGDVLYEITEHKDTVTETHFSHDGVYLATGDLA 149
            |...:...||.|:....:|.|||..|.:|.||.......:..|...:|..|..::..:..:.|..
Frog    36 HKGGINWMSLSPDGCHLLTASEDCTARLWRTSDNQCCNVLLGHSSYITFCHLENEAAFTCSADQT 100

  Fly   150 GDLFVFKVSEKHDERPILTKIWEYSMSDMSWLFWHRAA---HILLAGSDSGEVFVFRIPSGECKI 211
                              .:.||.|..:...::....:   .||:|   .|.:|     ||..
Frog   101 ------------------VRKWEVSSGECVMVYTGHTSIVNRILVA---KGYIF-----SGSY-- 137

  Fly   212 LPGQSSRCESGELSGDGKKLFTAYVNGSVKLWDLKSCQVL--IDVNESHPMGFGEITHAVVACER 274
              .:::|..:.: ||...:.|..:.|..:.|....|..||  :||.|.      |:...:|....
Frog   138 --DRTARSWNAD-SGQSLQEFRGHRNCVLTLAHFSSYDVLEALDVEEK------EVKEFLVTGST 193

  Fly   275 ESPFYVCAEASGEC----------------SSGKGIRYNTSFHNKTIRKMLFCTNNGPVSTIQSE 323
            :....:...:||.|                .:..|..|:.|. :.|||:....|  |...|:...
Frog   194 DCTIKIWEASSGCCYQTLRGHVGAILCVVLDTSNGELYSGSM-DCTIRRWNMVT--GDQLTVFRH 255

  Fly   324 H--GIECLAFAPSSADLKLFACGSLDGRISIW-DYAKSALRTICENPVPNDAVIRIKWLNDHTIL 385
            |  .:.||....     :|...||:|..:..| ......:||.   .....:|..:|:   |..:
Frog   256 HQGSVICLEIVG-----RLLYSGSVDRTVKCWLTDTGDCVRTY---KTHKHSVSTLKY---HAGI 309

  Fly   386 AATSQGN--LNAFDARTGILKFTLTGHYYHIYEFVYKPQENLLLTVSEDNTAKIFKVPAL 443
            ..|..|:  ..||:.::|.|:....||.:.|.  ..:..:|.|.|.|.|...:::.:..|
Frog   310 LFTGSGDACARAFNTKSGTLQRVFQGHSFIIN--CIQIHDNSLYTASHDGALRVWDIKDL 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	79/379 (21%)
		WD40	<81..441	CDD:225201	79/381 (21%)
		WD40 repeat	89..126	CDD:293791	11/36 (31%)
		WD40 repeat	132..170	CDD:293791	3/37 (8%)
		WD40 repeat	175..213	CDD:293791	7/40 (18%)
		WD40 repeat	220..299	CDD:293791	18/96 (19%)
		WD40 repeat	266..321	CDD:293791	13/70 (19%)
		WD40 repeat	326..365	CDD:293791	9/39 (23%)
		WD40 repeat	373..408	CDD:293791	9/36 (25%)
		WD40 repeat	414..438	CDD:293791	6/23 (26%)
wdr86	XP_002932539.2	WD40	29..320	CDD:238121	67/334 (20%)
		WD40 repeat	41..77	CDD:293791	11/35 (31%)
		WD40 repeat	123..157	CDD:293791	11/46 (24%)
		WD40 repeat	162..212	CDD:293791	12/55 (22%)
		WD40 repeat	219..254	CDD:293791	9/37 (24%)
		WD40 repeat	260..294	CDD:293791	9/41 (22%)
		WD40 repeat	300..333	CDD:293791	9/35 (26%)
		WD40	326..363	CDD:197651	10/38 (26%)
		WD40 repeat	340..362	CDD:293791	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010