DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and aamp

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_001096285.1	Gene:	aamp / 100124854	XenbaseID:	XB-GENE-1010095	Length:	443	Species:	Xenopus tropicalis

Alignment Length:	442	Identity:	140/442 - (31%)
Similarity:	220/442 - (49%)	Gaps:	52/442 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DDELQEIIELEEQPLDEDD--DDLEEVTLEQLEARLAMAGGDDDEEEDE--EELRDRERIAAITD 76
            |:|:.|::||.:...|.||  .|:|:|..........||..::.|.|||  ||..|..      |
Frog    32 DEEIIEVLELNDVEPDPDDLASDMEDVDFADDPEDGEMADNEEWETEDEGVEEGTDPH------D 90

  Fly    77 EATVTFKKHTAPVFACSLHPNYN-WAVTGSEDDRAFVWETSTGDVLYEITEHKDTVTETHFSHDG 140
            ::.:||.||||.||..||.|..: .||||.|||:|::|..|.|:.::|.|.|||:||...||||.
Frog    91 DSELTFSKHTASVFCVSLDPKESALAVTGGEDDKAYIWRLSDGETVFECTGHKDSVTCAVFSHDS 155

  Fly   141 VYLATGDLAGDLFVFKVSEKHDERPILTKIWEYSMSDMSWLFWHRAAHILLAGSDSGEVFVFRIP 205
            ..:||||::|.:.|:||....:       ||.:.:.|:.||.||..||:||||:..|..::::||
Frog   156 TMVATGDMSGLIKVWKVEGAEE-------IWSFEVGDLEWLEWHPCAHVLLAGTADGNTWMWKIP 213

  Fly   206 SGECKILPGQSSRCESGELSGDGKKLFTAYVNGSVKLWDLKSCQVLIDVNESHPMGFGEITHAVV 270
            |||||...|.|.....|:...||:|....|.:|||::||||.               |...|.:.
Frog   214 SGECKTFQGPSCPATCGQFLPDGRKAVVGYEDGSVRIWDLKQ---------------GNALHVLK 263

  Fly   271 ACERESPFYVCAEASGECS---SGKGIRYNTSFHNKTIRKM--LFCTNNGPVSTIQSEHG----- 325
            ..:..:....|..::.:.|   :| .:..:|...|....|:  :|.|.:......:.|.|
Frog   264 GTDGHAGPLTCVASNNDGSLVLTG-SVDCDTKLVNTATGKVVGVFKTESNVSKASRREDGEAESN 327

  Fly   326 -IECLAFAPSSADLKLFACGSLDGRISIWDYAKSALRTICENPVPNDAVIRIKW-LNDHTILAAT 388
             :|.|.|...   |.|.|.|.|||.::::|.:..:||..|::   ...::::.| .|...:...:
Frog   328 SVESLGFCNV---LPLAAVGYLDGTLAVYDLSSQSLRHRCQH---ESGIVQLLWEQNSPVVYTCS 386

  Fly   389 SQGNLNAFDARTGILKFTLTGHYYHIYEFVYKPQENLLLTVSEDNTAKIFKV 440
            ..|.:..:|:|:|.:.....||...|.:|......::::|.|.|:.||:|.|
Frog   387 LDGAVRLWDSRSGKMISEYCGHTAEILDFALNKDASIVVTASGDHQAKVFCV 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	117/372 (31%)
		WD40	<81..441	CDD:225201	119/373 (32%)
		WD40 repeat	89..126	CDD:293791	17/37 (46%)
		WD40 repeat	132..170	CDD:293791	13/37 (35%)
		WD40 repeat	175..213	CDD:293791	19/37 (51%)
		WD40 repeat	220..299	CDD:293791	17/81 (21%)
		WD40 repeat	266..321	CDD:293791	9/59 (15%)
		WD40 repeat	326..365	CDD:293791	13/38 (34%)
		WD40 repeat	373..408	CDD:293791	6/35 (17%)
		WD40 repeat	414..438	CDD:293791	7/23 (30%)
aamp	NP_001096285.1	WD40	95..395	CDD:238121	105/328 (32%)
		WD40 repeat	103..141	CDD:293791	17/37 (46%)
		WD40 repeat	183..221	CDD:293791	19/37 (51%)
		WD40 repeat	228..265	CDD:293791	14/51 (27%)
		WD40 repeat	272..321	CDD:293791	8/49 (16%)
		WD40 repeat	329..365	CDD:293791	13/38 (34%)
		WD40 repeat	370..394	CDD:293791	3/23 (13%)
		WD40	398..436	CDD:197651	10/37 (27%)
		WD40 repeat	412..436	CDD:293791	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H846
Inparanoid	1	1.050	212	1.000	Inparanoid score	I3560
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1025450at2759
OrthoFinder	1	1.000	-	-		FOG0003404
OrthoInspector	1	1.000	-	-		oto104101
Panther	1	1.100	-	-	LDO	PTHR19857
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1794
SonicParanoid	1	1.000	-	-		X3860
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190