DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5114 and plrg1

DIOPT Version :9

Sequence 1:	NP_001246760.1	Gene:	CG5114 / 39624	FlyBaseID:	FBgn0036460	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_998605.1	Gene:	plrg1 / 100004402	ZFINID:	ZDB-GENE-040426-2787	Length:	511	Species:	Danio rerio

Alignment Length:	382	Identity:	84/382 - (21%)
Similarity:	136/382 - (35%)	Gaps:	121/382 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 HTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGDVLYEITEHKDTVTETHFSHDGVYLATGDLA 149
            |...|.:.::.|...|.||||.|....:|:.::|.:...:|.|..||.....|:...||
Zfish   200 HLGWVRSIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVAVSNRSPYL------ 258

  Fly   150 GDLFVFKVSEKHDERPILTKIW--EYS---------MSDMSWLFWHRAAHILLAGSDSGEVFVFR 203
                 |...|  |::   .|.|  ||:         :|.:..|..|....:|:..|......|:.
Zfish   259 -----FSCGE--DKQ---VKCWDLEYNKVIRHYHGHLSAVYDLDLHPTIDVLVTCSRDATARVWD 313

  Fly   204 I-PSGECKILPGQSS-----RCESGELSGDGKKLFTAYVNGSVKLWDL---KSCQVLIDVNESHP 259
            | .......|.|.::     :|:|.|     .::.|...:.:::||||   |:...|.:..:|
Zfish   314 IRTKANVHTLSGHTNTVATVKCQSAE-----PQVVTGSHDTTIRLWDLVAGKTRATLTNHKKS-- 371

  Fly   260 MGFGEITHAVVACERESPFYVCAEASGECSSGKGIRY-------NTSFHNKTIRKMLFCTNNGPV 317
                  ..|:|...|:..|     |||...:.|..::       |.|.||..|..:...::...|
Zfish   372 ------VRALVLHPRQYTF-----ASGSPDNIKQWKFPDGNFIQNLSGHNAIINTLAVNSDGVLV 425

  Fly   318 STIQSEHGIECLAFAPSSADLKLFACGSLDGRISIWDYAKSALRTICENPVPNDAVIRIKWLNDH 382
            |                         |:.:|.|.:||:     ||               ..|..
Zfish   426 S-------------------------GADNGTIHMWDW-----RT---------------GYNFQ 445

  Fly   383 TILAATSQGNLNAFDARTGILKFTLTGHYYHIYEFVYKPQENLLLTVSEDNTAKIFK 439
            .|.||...|:|   |:.:|            |:..|:...|:.|:|...|.|.|::|
Zfish   446 RIHAAVQPGSL---DSESG------------IFSCVFDQSESRLITAEADKTIKVYK 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5114	NP_001246760.1	WD40	79..439	CDD:295369	83/380 (22%)
		WD40	<81..441	CDD:225201	84/382 (22%)
		WD40 repeat	89..126	CDD:293791	10/36 (28%)
		WD40 repeat	132..170	CDD:293791	6/37 (16%)
		WD40 repeat	175..213	CDD:293791	7/38 (18%)
		WD40 repeat	220..299	CDD:293791	19/88 (22%)
		WD40 repeat	266..321	CDD:293791	15/61 (25%)
		WD40 repeat	326..365	CDD:293791	7/38 (18%)
		WD40 repeat	373..408	CDD:293791	8/34 (24%)
		WD40 repeat	414..438	CDD:293791	8/23 (35%)
plrg1	NP_998605.1	WD40	<190..504	CDD:225201	84/382 (22%)
		WD40	193..487	CDD:238121	83/380 (22%)
		WD40 repeat	206..241	CDD:293791	9/34 (26%)
		WD40 repeat	247..283	CDD:293791	10/51 (20%)
		WD40 repeat	288..324	CDD:293791	6/35 (17%)
		WD40 repeat	331..366	CDD:293791	9/39 (23%)
		WD40 repeat	372..407	CDD:293791	9/39 (23%)
		WD40 repeat	413..451	CDD:293791	13/82 (16%)
		WD40 repeat	462..486	CDD:293791	8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010