Protein Alignment DCX-EMAP and DCDC2C

DIOPT Version :10

• Sequence 1: NP_001261850.1
• Gene: DCX-EMAP / 39617
• FlyBaseID: FBgn0259099
• Length: 1118
• Species: Drosophila melanogaster
• Sequence 2: XP_006711957.1
• Gene: DCDC2C / 728597
• HGNCID: 32696
• Length: 373
• Species: Homo sapiens
• Alignment Length: 400
• Identity: 91/400 - (22%)
• Similarity: 154/400 - (38%)
• Gaps: 88/400 - (22%)

  Fly   170 ARRVVFYRNGDPFFPGVELRYRPGRDVTSLDNLLDKISPKMDLPRGARYVFS-MDGDRKYHLDEL 233
            |:.:|.|||||||:.|.:......|..| .:.||::::.::|:|.|.|.:|: ..|.|...||.|
Human    15 AKTIVVYRNGDPFYVGKKFVLSRRRAAT-FEALLEQLTEQVDVPFGVRRLFTPTRGHRVLGLDAL 78

  Fly   234 EDGAFYVVSSFKAFKPASYGKKNGMWYASPGNQGWGSKPAS-RK----PSIMEADLGTLSTTSGS 293
            :.|..||.:..:.||...|      .:..|      .|||. ||    ..::..|:...|..
Human    79 QAGGKYVAAGRERFKELDY------IHIVP------RKPAKIRKLKEIKPVVHCDINVPSKW--- 128

  Fly   294 IKRSAGRVIRIINNLDHS----VQCRVLLNLRTSQPFEEVLEDLGQ-VLKINGAKKMYTGTGQEV 353
              ::..|:.|.||...:.    ...::::...:...::.||..:|: |..:.|.:|::|..|..:
Human   129 --QTYHRISRHINVFTNGRLFIPPAKIIIPKFSLSDWDIVLATIGEKVFPLGGVRKLFTMNGHLL 191

  Fly   354 RSFSQLRNEFADVDTFYLATGTALIAGSPIRRSRSRPSVVA---AAPILPTDELPKVPLRGARP- 414
            .....|::     :.||:|.|.......|..:|...||.|.   |.....:....||..:|..|
Human   192 GDSKDLQD-----NHFYVAVGLETFKYFPYWKSPRVPSEVQQRYANVEKNSQRKKKVDSKGKEPC 251

  Fly   415 -----RSKSRPRILYAPESEILRPNGEYTMLDIMKEEPTKVTIRGL-RRTFYPPVHHAPADNSPP 473
                 ..|::..:.||                  |||..|.....| :|.....|:.||..:...
Human   252 KYDGIPPKTQDSVYYA------------------KEEKKKTLAEPLVQRGAEGDVYKAPTPSKET 298

  Fly   474 DKKLQLQWVHGYR---GIDARRNLWVLPSGELLYYVAAVAVLFDRDEDAQRH---YTGH--TEDI 530
            ...|.::..|..:   .:|.|:                 |.:...||:...:   :.|:  .||.
Human   299 QGALDVKEEHNVQLEVPVDQRQ-----------------AEIVKEDEEIHENTPDFEGNKDKEDA 346

  Fly   531 -MCMDVHPSR 539
             :|.||...|
Human   347 RLCEDVERKR 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCX-EMAP	NP_001261850.1	DCX	166..253	CDD:214711	29/83 (35%)
		DCX2_RP_like	300..372	CDD:340590	15/76 (20%)
		HELP	449..515	CDD:460922	11/69 (16%)
		WD40	520..562	CDD:459801	6/25 (24%)
		WD40 repeat	530..573	CDD:293791	3/10 (30%)
		WD40	548..959	CDD:441893
		WD40 repeat	582..624	CDD:293791
		WD40 repeat	627..664	CDD:293791
		WD40 repeat	673..712	CDD:293791
		WD40 repeat	718..801	CDD:293791
		WD40 repeat	806..838	CDD:293791
		WD40 repeat	846..880	CDD:293791
		WD40	847..>1073	CDD:475233
		WD40 repeat	886..918	CDD:293791
		WD40 repeat	931..969	CDD:293791
		WD40 repeat	1002..1037	CDD:293791
DCDC2C	XP_006711957.1	DCX1_DCDC2C	16..94	CDD:340671	27/78 (35%)
		DCX2_DCDC2C	135..213	CDD:340674	16/82 (20%)