Protein Alignment DCX-EMAP and Rp1l1

DIOPT Version :10

• Sequence 1: NP_001261850.1
• Gene: DCX-EMAP / 39617
• FlyBaseID: FBgn0259099
• Length: 1118
• Species: Drosophila melanogaster
• Sequence 2: NP_001408014.1
• Gene: Rp1l1 / 683404
• RGDID: 1586886
• Length: 1860
• Species: Rattus norvegicus
• Alignment Length: 730
• Identity: 145/730 - (19%)
• Similarity: 239/730 - (32%)
• Gaps: 255/730 - (34%)

  Fly   170 ARRVVFYRNGDPFFPGVELRYRPGRDVTSLDNLLDKISPKMDLPRGARYVFSMDGDRKYH----L 230
            |:::.|.:.|||.|.||.|.... |...:...|:|::|.:|.|..|.|   |:...|..|    |
  Rat    41 AKKITFLKRGDPQFAGVRLAVHQ-RTFKTFSALMDELSQRMPLSFGVR---SVTTPRGLHGLSAL 101

  Fly   231 DELEDGAFYVVSSFKAFKPASYGKKNGMWYASPGNQGWGSKPASRKPSIMEADLGTLSTTSGSIK 295
            ::|:||..|:.|.   .||....:::|.....       |.||.|. .:.:.......|:|.|.|
  Rat   102 EQLQDGGCYLCSD---RKPPKTPRESGRLQRK-------SPPAGRS-QVSQGGHEAPETSSYSWK 155

  Fly   296 R-SAGRVIRIINNLDHSVQCRVLLNLRTSQPFEEVLEDLGQVLKINGAKKMYTGTGQEVRSFSQL 359
            . .|.|.:.::.|.....|..|:|:.:.::.....|....::|:. ..|::||..|::|.|...|
  Rat   156 NPMAPRRLTLVKNGYPGCQQTVVLSHKNTRNLAGFLSKASELLRF-PVKQVYTTHGKKVDSLQTL 219

  Fly   360 RNEFADVDTFYLATG----------------TALIAGSPIRRSR------SRPSVVAAAPILPTD 402
                .|..:..:..|                |.:::|...|..|      ::.||:.:
  Rat   220 ----LDGPSLLVCAGNEAFRRLEMENDRGNRTRMVSGVTARSERGCWGPNAKQSVIHS------- 273

  Fly   403 ELPKVPLRGARPRSKSRPRILYAPESEILRPNGEYTMLDIMKEEPTKVTIRGLRRTFYPPVHH-- 465
                   ||                    |..|:.....:|.|.      .||  :.:|...|
  Rat   274 -------RG--------------------RSGGKLRQFSLMSER------SGL--SDHPASGHQA 303

  Fly   466 --APA-DNSPPDKKLQLQWVHGYRGIDARRNLWVLPSGELLYYVAAVAVLFDRDEDAQRHYTGHT 527
              .|| |..|.|..                    .|.|.|   |||        :|.::.
  Rat   304 WAGPALDRCPQDTP--------------------APPGSL---VAA--------DDVEKK----- 332

  Fly   528 EDIMCM--DVHPSRELVASGQKAGRD--RKSQ--AHVRIWSTES--------------LQTLYVF 572
               :||  |...|.|:....|..|.|  |.||  .|..:::..:              .|..|.:
  Rat   333 ---VCMNEDGSLSVEMKVRFQLLGEDTLRWSQRVGHASVFTAATGEDRDLREADRLCCRQEGYPW 394

  Fly   573 GMGELDSGVTAVAFSQLNGGSYILAVDSGRESILSVWQW----------------QWGHLLGKVA 621
            |:  |:.|  |......:||.. .|.|.|::|..|...|                :||  |.|::
  Rat   395 GV--LEPG--AQGLGPHDGGCQ-GAFDVGQQSRPSYDIWRNPLTAPEGTGPTPRRRWG--LAKLS 452

  Fly   622 TL-QEGLSGAAFHPLDDNLIITHGRGHLAFWHRRKDGFFERTDIVKQPSRSHVTSVQ------FE 679
            .. :||.:..              :||            ::.:.....:..|..|||      :.
  Rat   453 RCWREGTNDR--------------KGH------------DKANASPVSTPRHPGSVQPGSCCLWT 491

  Fly   680 PDGDVITADSDGFITIYSVDSDGAYFVRTEFEAHNKGIGCLIMLGE-GTLLSGGEKDRKIAAWDS 743
            |:   :...||....:.|..|      |:|.:..:....||...|. |..|.....||      :
  Rat   492 PE---VETGSDTLRPVSSASS------RSETDLESGEDPCLEDTGPCGLRLQTQSIDR------A 541

  Fly   744 LQNYKKIADTKLPEAAGGVRTIYPQRPGRNDGNIYVGTTRNNILEGSLQRRFTQVVFGHGRQLWG 808
            |.:....|:::.....||             |.::.|:::..::...                 |
  Rat   542 LSDTSASAESREESCEGG-------------GQLHRGSSQARVMASQ-----------------G 576

  Fly   809 LAAHPDDELYATAGH 823
            .|...|:...:|..|
  Rat   577 QATRGDNPCISTQRH 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCX-EMAP	NP_001261850.1	DCX	166..253	CDD:214711	28/86 (33%)
		DCX2_RP_like	300..372	CDD:340590	15/71 (21%)
		HELP	449..515	CDD:460922	15/70 (21%)
		WD40	520..562	CDD:459801	12/47 (26%)
		WD40 repeat	530..573	CDD:293791	14/62 (23%)
		WD40	548..959	CDD:441893	57/318 (18%)
		WD40 repeat	582..624	CDD:293791	13/58 (22%)
		WD40 repeat	627..664	CDD:293791	2/36 (6%)
		WD40 repeat	673..712	CDD:293791	10/44 (23%)
		WD40 repeat	718..801	CDD:293791	13/83 (16%)
		WD40 repeat	806..838	CDD:293791	5/18 (28%)
		WD40 repeat	846..880	CDD:293791
		WD40	847..>1073	CDD:475233
		WD40 repeat	886..918	CDD:293791
		WD40 repeat	931..969	CDD:293791
		WD40 repeat	1002..1037	CDD:293791
Rp1l1	NP_001408014.1	Ubl1_cv_Nsp3_N-like	42..120	CDD:475130	27/84 (32%)
		Ubl1_cv_Nsp3_N-like	161..235	CDD:475130	16/78 (21%)