Protein Alignment DCX-EMAP and eml5

DIOPT Version :10

• Sequence 1: NP_001261850.1
• Gene: DCX-EMAP / 39617
• FlyBaseID: FBgn0259099
• Length: 1118
• Species: Drosophila melanogaster
• Sequence 2: XP_068070724.1
• Gene: eml5 / 570011
• ZFINID: ZDB-GENE-030131-1677
• Length: 1974
• Species: Danio rerio
• Alignment Length: 741
• Identity: 207/741 - (27%)
• Similarity: 337/741 - (45%)
• Gaps: 111/741 - (14%)

  Fly   414 PRSKSRPRILYAPESEILRPNGEYT--------MLDIMKEEPTKVTIRGLRRTFY----PPV--- 463
            |..||:..:..||:..::..:.|.:        .:|...|:.|::|   .||..|    |.:
Zfish   603 PERKSKDTLHIAPQETLIDSHSEESDSDQSDVPEMDSEIEQETQLT---YRRQVYKEDLPQLKEQ 664

  Fly   464 ----HHAPA---DNSPPDKKLQLQWVHGYRGIDARRNLWVLPSGELLYYVAAVAVLFDRDEDAQR 521
                |.|.|   ....|...::|.::|||||.|.|.||:...:||::|:||||.|:::|.::.||
Zfish   665 CKEKHRAMAMKKRERAPASGMRLHFIHGYRGYDCRSNLFYTQTGEIVYHVAAVGVVYNRQQNTQR 729

  Fly   522 HYTGHTEDIMCMDVHPSRELVASGQKAGRDRKSQAHVRIWSTESLQTLYVFGMGELDSGVTAVAF 586
            .|.||.:||:|:.:||.::.||:|| .|||    :.:.||.||.|:.|.|. .|....||.|:.|
Zfish   730 FYLGHDDDILCLAIHPVKDYVATGQ-VGRD----SSIHIWETEFLKPLSVL-KGFHQFGVCALDF 788

  Fly   587 SQLNGGSYILAVDSGRESILSVWQWQWGHLLGKVATLQEGLSGAAFHPLDDNLIITHGRGHLAFW 651
            |.  .|..:.:|.......:.:|:|:.|..|..:...::.:.....:|...:.:|:.|..|:.||
Zfish   789 SA--DGKRLASVGLDDNHTIVLWEWRKGEKLSTIRGSKDKIFVIKINPYMPDKLISAGVKHMKFW 851

  Fly   652 HRR------KDGFFERTDIVKQPSRSHVTSVQFEPDGDVITADSDGFITIYSVDSDGAYFVRTEF 710
            ||.      |.|...:|:.:       :.:|....:..|.:....|.|.|:.    ..:.|:| .
Zfish   852 HRAGGGLIGKKGSMGKTETM-------MCAVYGWTEEMVFSGTCTGDICIWR----DMFLVKT-V 904

  Fly   711 EAHNKGIGCLIMLGEGTLLSGGEKDRKIAAWDS-----LQNYKKIADTKLPEAAG-------GVR 763
            :||:..:..:..|.:| .::|| ||..:|.||.     |:.|........|.:.|       .:|
Zfish   905 KAHDGPVFSMHALEKG-FVTGG-KDGIVALWDDTFERCLKTYAIKRAVLAPGSKGLLLEDNPSIR 967

  Fly   764 TIYPQRPGRNDGNIYVGTTRNNILEGSLQRRFTQVVFGHGR-QLWGLAAHPDDELYATAGHDKHV 827
            .|     ....|:|.|||....|||.......|.:|.||.. ::||||.||...|.||...||.:
Zfish   968 AI-----SLGHGHILVGTKNGEILEVDKNGPITLLVQGHMEGEVWGLATHPHLPLCATVSDDKTL 1027

  Fly   828 ALW-----------RKNKLIWTIQTGYECVALAFHPFG-TLAAGSTEGHLLVINCENGAVMLTLR 880
            .:|           ||      ::.|..|  ..|.|.| .||.|..:|..|::|.:....:::..
Zfish  1028 RIWDLSPSHCMLAVRK------LKKGGRC--CCFSPDGKALAVGLNDGSFLIVNADTLEDLVSFH 1084

  Fly   881 VCGSPLNCVAYNQV-GDMIAMGSQNGSIYLFRVSRDGFSYKKVNKIRGSQP-LTHLDWSMDGNFV 943
            .....::.:.::.| |..:|:.|.:..:.::.|    .|.|:|...:||.. :|||||...|..:
Zfish  1085 HRKDIISEIRFSPVTGKYLAVASGDSFVDIYNV----MSSKRVGVCKGSMNYITHLDWDKRGKLL 1145

  Fly   944 QTVTIDFDLLFWDAKSLSPERSPIA-MKDVKWLTNNCTVGFLVAGQWSNRYYSTTNTIVATCSRS 1007
            |..|...:.||::|.....:..|:. ::.:.|.|..|.:|....|.|.  ..|....:.|.|
Zfish  1146 QVNTSAKEQLFFEAPRGKKQSIPVTEVEKIDWSTWTCVLGSSCEGIWP--VVSEVTEVTAAC--- 1205

  Fly  1008 AAHD--MLASGDAEGYLRLFRYPCISPRAEFHESKVYSGMLACVRFLCGDHTLITVGGTDASLMV 1070
            .::|  :||:||..||::||:||.....|:|.....:|..:..||:...|..|.:|||:|..||:
Zfish  1206 LSYDKKLLATGDDLGYVKLFKYPVKGKYAKFKRYMAHSTHVTNVRWSHDDSLLASVGGSDTCLMI 1270

  Fly  1071 WDIVEEXLKWPPWHRTAAQYEASYSD 1096
            |:...|..      |.|.|.::..||
Zfish  1271 WNHETESC------REARQCDSEESD 1290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCX-EMAP	NP_001261850.1	DCX	166..253	CDD:214711
		DCX2_RP_like	300..372	CDD:340590
		HELP	449..515	CDD:460922	27/79 (34%)
		WD40	520..562	CDD:459801	18/41 (44%)
		WD40 repeat	530..573	CDD:293791	18/42 (43%)
		WD40	548..959	CDD:441893	115/443 (26%)
		WD40 repeat	582..624	CDD:293791	9/41 (22%)
		WD40 repeat	627..664	CDD:293791	11/42 (26%)
		WD40 repeat	673..712	CDD:293791	7/38 (18%)
		WD40 repeat	718..801	CDD:293791	25/94 (27%)
		WD40 repeat	806..838	CDD:293791	14/42 (33%)
		WD40 repeat	846..880	CDD:293791	9/34 (26%)
		WD40	847..>1073	CDD:475233	65/231 (28%)
		WD40 repeat	886..918	CDD:293791	5/32 (16%)
		WD40 repeat	931..969	CDD:293791	12/38 (32%)
		WD40 repeat	1002..1037	CDD:293791	14/36 (39%)
eml5	XP_068070724.1	HELP	<2..48	CDD:460922
		WD40	58..445	CDD:441893
		WD40 repeat	64..104	CDD:293791
		WD40 repeat	110..148	CDD:293791
		WD40 repeat	153..201	CDD:293791
		WD40 repeat	203..233	CDD:293791
		WD40 repeat	240..279	CDD:293791
		WD40 repeat	294..329	CDD:293791
		WD40	329..809	CDD:441893	69/216 (32%)
		WD40 repeat	336..360	CDD:293791
		WD40 repeat	378..414	CDD:293791
		WD40 repeat	419..458	CDD:293791
		WD40 repeat	529..568	CDD:293791
		WD40	733..1071	CDD:238121	103/372 (28%)
		WD40 repeat	738..777	CDD:293791	18/44 (41%)
		WD40 repeat	783..822	CDD:293791	10/40 (25%)
		WD40 repeat	827..905	CDD:293791	18/89 (20%)
		WD40	900..1275	CDD:441893	112/399 (28%)
		WD40 repeat	912..999	CDD:293791	24/93 (26%)
		WD40 repeat	1006..1040	CDD:293791	12/33 (36%)
		WD40 repeat	1048..1074	CDD:293791	9/27 (33%)
		WD40 repeat	1090..1115	CDD:293791	4/24 (17%)
		WD40 repeat	1134..1189	CDD:293791	16/54 (30%)
		WD40 repeat	1201..1240	CDD:293791	15/41 (37%)
		WD40 repeat	1246..1273	CDD:293791	11/26 (42%)
		HELP	1341..1406	CDD:460922
		WD40 repeat	1343..1408	CDD:293791
		WD40 repeat	1423..1470	CDD:293791
		WD40	1425..1812	CDD:441893
		WD40 repeat	1477..1519	CDD:293791
		WD40 repeat	1540..1605	CDD:293791
		WD40 repeat	1610..1654	CDD:293791
		WD40 repeat	1662..1695	CDD:293791
		WD40	<1686..1968	CDD:441893
		WD40 repeat	1702..1739	CDD:293791
		WD40 repeat	1744..1780	CDD:293791
		WD40 repeat	1785..1824	CDD:293791
		WD40 repeat	1831..1890	CDD:293791
		WD40 repeat	1897..1936	CDD:293791