Protein Alignment DCX-EMAP and DCX-EMAP

DIOPT Version :10

• Sequence 1: NP_001261850.1
• Gene: DCX-EMAP / 39617
• FlyBaseID: FBgn0259099
• Length: 1118
• Species: Drosophila melanogaster
• Sequence 2: XP_061502766.1
• Gene: DCX-EMAP / 1271739
• VectorBaseID: AGAMI1_012794
• Length: 1532
• Species: Anopheles gambiae
• Alignment Length: 1120
• Identity: 771/1120 - (68%)
• Similarity: 882/1120 - (78%)
• Gaps: 90/1120 - (8%)

  Fly     7 NAPLEGNVSPPPTQPHLD-DNLHNGN-----GNGNGIHSSSSNINKHGSNINGNNDSNRSSPAKS 65
            ::||.|...|....|.:. |.|.:|.     |.|.|   ......:.|..:      .|.|..:|
Mosquito   453 SSPLAGRRHPVHVNPVISRDKLASGGVSGGIGGGGG---GGWGPRQRGGPV------ERGSRIQS 508

  Fly    66 PKRPVSSSFRIQNTSRYDNDEEDLAASE------QVAGGDRQVPDYWQQRNGATTGATSGRQSRA 124
            |.....::......:..|...|..|.:.      ..|||.:|     ||:...|..:|.|....|
Mosquito   509 PATGTGTALPPGAGTSMDVGGEGAAGTPVAAGNGPAAGGQQQ-----QQQQPGTAASTPGAAGAA 568

  Fly   125 ISPGYLDNMSENSEQPPVVPLVRSKSRPEI---SSAAA--------------------SRYNNLS 166
            .:|               .|:.||:||.::   .||..                    |||:|||
Mosquito   569 PAP---------------APVKRSQSRNDVLDLDSAPGPSGLLPSNPGVPGTIGGNPQSRYSNLS 618

  Fly   167 YWKARRVVFYRNGDPFFPGVELRYRPGRDVTSLDNLLDKISPKMDLPRGARYVFSMDGDRKYHLD 231
            :||||||:|||||||||||||.|::||||:.:|:.||||||.:|||||||||:|||||||||.||
Mosquito   619 FWKARRVLFYRNGDPFFPGVEFRFKPGRDICTLEALLDKISARMDLPRGARYIFSMDGDRKYSLD 683

  Fly   232 ELEDGAFYVVSSFKAFKPASYGKKNGMWYASPGNQGWGS--KPA--SRKPSIMEADLGTLSTTSG 292
            |||||:.|||||||.|||||||||||:||||||||||||  .||  .||||:.|.|    :..||
Mosquito   684 ELEDGSSYVVSSFKVFKPASYGKKNGVWYASPGNQGWGSGAGPARLGRKPSVTEVD----NMPSG 744

  Fly   293 SIKRSAGRVIRIINNLDHSVQCRVLLNLRTSQPFEEVLEDLGQVLKINGAKKMYTGTGQEVRSFS 357
            |:|.||||||||||:.||||||||||||||||||||||||||||||:.|||||||..||||||||
Mosquito   745 SLKPSAGRVIRIINSHDHSVQCRVLLNLRTSQPFEEVLEDLGQVLKMIGAKKMYTSNGQEVRSFS 809

  Fly   358 QLRNEFADVDTFYL---------ATGTALIAGSPIRRSRSRPSVVAAAPILPTDELPKVPLRGAR 413
            |||||||:|:||||         |.|..:|..||.||||||  :..:.|    |:|.|...| .|
Mosquito   810 QLRNEFAEVETFYLSNTPSLPVGALGPGVIPPSPGRRSRSR--LGGSVP----DDLSKTTAR-QR 867

  Fly   414 PRSKSRPRILYAPESEILRPNGEYTMLDIMKEEPTKVTIRGLRRTFYPPVHHAPADNSPPDKKLQ 478
            .|||||||:|||||:|::|.:.:|.:||.||||||::||||||||||||:||.|.||:||||||.
Mosquito   868 ARSKSRPRVLYAPENELVRASSDYPLLDAMKEEPTRITIRGLRRTFYPPLHHPPIDNAPPDKKLS 932

  Fly   479 LQWVHGYRGIDARRNLWVLPSGELLYYVAAVAVLFDRDEDAQRHYTGHTEDIMCMDVHPSRELVA 543
            |.|||||||||::|||||||||||||||||||||:||:|||||||||||||||||:||||||||.
Mosquito   933 LFWVHGYRGIDSKRNLWVLPSGELLYYVAAVAVLYDREEDAQRHYTGHTEDIMCMEVHPSRELVG 997

  Fly   544 SGQKAGRDRKSQAHVRIWSTESLQTLYVFGMGELDSGVTAVAFSQLNGGSYILAVDSGRESILSV 608
            |||:||||||||||||||||||||||||||||||||||.|||||||||||||||||:||||||||
Mosquito   998 SGQRAGRDRKSQAHVRIWSTESLQTLYVFGMGELDSGVIAVAFSQLNGGSYILAVDAGRESILSV 1062

  Fly   609 WQWQWGHLLGKVATLQEGLSGAAFHPLDDNLIITHGRGHLAFWHRRKDGFFERTDIVKQPSRSHV 673
            ||||||||||||||||||:.||.||||||||:||||||||||||||||||||:|||:|.|||:.|
Mosquito  1063 WQWQWGHLLGKVATLQEGIWGATFHPLDDNLLITHGRGHLAFWHRRKDGFFEKTDIIKPPSRTFV 1127

  Fly   674 TSVQFEPDGDVITADSDGFITIYSVDSDGAYFVRTEFEAHNKGIGCLIMLGEGTLLSGGEKDRKI 738
            |.||||||||||||||||||||||||:|||||||.|||||||.|.||:||.||||:|||||||||
Mosquito  1128 TCVQFEPDGDVITADSDGFITIYSVDADGAYFVRMEFEAHNKAISCLVMLSEGTLISGGEKDRKI 1192

  Fly   739 AAWDSLQNYKKIADTKLPEAAGGVRTIYPQRPGRNDGNIYVGTTRNNILEGSLQRRFTQVVFGHG 803
            ||||||||||:|.|.||||:|||||:|||||||||||||||||||||||||||||||.||:||||
Mosquito  1193 AAWDSLQNYKRITDIKLPESAGGVRSIYPQRPGRNDGNIYVGTTRNNILEGSLQRRFNQVIFGHG 1257

  Fly   804 RQLWGLAAHPDDELYATAGHDKHVALWRKNKLIWTIQTGYECVALAFHPFG-TLAAGSTEGHLLV 867
            :.||.||||||||::||.||||:|||||:.|||||...|||.:||||||:| .|||||:||||:|
Mosquito  1258 KHLWALAAHPDDEVFATGGHDKYVALWRRQKLIWTTSVGYEIIALAFHPYGAALAAGSSEGHLIV 1322

  Fly   868 INCENGAVMLTLRVCGSPLNCVAYNQVGDMIAMGSQNGSIYLFRVSRDGFSYKKVNKIRGSQPLT 932
            ||.||||.|||:||||||||.|.:||||||||:|||||||||||||||||||||:||||||||||
Mosquito  1323 INAENGATMLTIRVCGSPLNAVEFNQVGDMIAIGSQNGSIYLFRVSRDGFSYKKINKIRGSQPLT 1387

  Fly   933 HLDWSMDGNFVQTVTIDFDLLFWDAKSLSPERSPIAMKDVKWLTNNCTVGFLVAGQWSNRYY-ST 996
            |||||.:|||:|:||:||||||||.||||||:||||||||||:|:||||||||||.|:|||| :.
Mosquito  1388 HLDWSSEGNFLQSVTVDFDLLFWDVKSLSPEKSPIAMKDVKWMTSNCTVGFLVAGLWNNRYYPAP 1452

  Fly   997 TNTIVATCSRSAAHDMLASGDAEGYLRLFRYPCISPRAEFHESKVYSGMLACVRFLCGDHTLITV 1061
            :|||:.|.:|:||.|::|:|||:|||||||||||:|||||.|:|||||.||.|:||.|:|:|:||
Mosquito  1453 SNTIITTTARTAAQDLVAAGDADGYLRLFRYPCITPRAEFTEAKVYSGTLAAVKFLYGNHSLVTV 1517

  Fly  1062 GGTDASLMVWDIVEE 1076
            ||||||||:|::.||
Mosquito  1518 GGTDASLMIWELTEE 1532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCX-EMAP	NP_001261850.1	DCX	166..253	CDD:214711	69/86 (80%)
		DCX2_RP_like	300..372	CDD:340590	64/80 (80%)
		HELP	449..515	CDD:460922	54/65 (83%)
		WD40	520..562	CDD:459801	38/41 (93%)
		WD40 repeat	530..573	CDD:293791	39/42 (93%)
		WD40	548..959	CDD:441893	352/411 (86%)
		WD40 repeat	582..624	CDD:293791	39/41 (95%)
		WD40 repeat	627..664	CDD:293791	31/36 (86%)
		WD40 repeat	673..712	CDD:293791	35/38 (92%)
		WD40 repeat	718..801	CDD:293791	71/82 (87%)
		WD40 repeat	806..838	CDD:293791	24/31 (77%)
		WD40 repeat	846..880	CDD:293791	26/34 (76%)
		WD40	847..>1073	CDD:475233	178/227 (78%)
		WD40 repeat	886..918	CDD:293791	27/31 (87%)
		WD40 repeat	931..969	CDD:293791	30/37 (81%)
		WD40 repeat	1002..1037	CDD:293791	24/34 (71%)
DCX-EMAP	XP_061502766.1	None