Protein Alignment DCX-EMAP and eml6

DIOPT Version :10

• Sequence 1: NP_001261850.1
• Gene: DCX-EMAP / 39617
• FlyBaseID: FBgn0259099
• Length: 1118
• Species: Drosophila melanogaster
• Sequence 2: XP_031758938.1
• Gene: eml6 / 100498213
• XenbaseID: XB-GENE-6039541
• Length: 2009
• Species: Xenopus tropicalis
• Alignment Length: 637
• Identity: 191/637 - (29%)
• Similarity: 306/637 - (48%)
• Gaps: 81/637 - (12%)

  Fly   473 PDKKLQLQWVHGYRGIDARRNLWVLPSGELLYYVAAVAVLFDRDEDAQRHYTGHTEDIMCMDVHP 537
            ||:.|:|::||||||.|.|.||:...:||::|:|||:||::||.:.:||.|.||.:||:.:.:||
 Frog   673 PDESLKLKFVHGYRGYDCRNNLFYTQAGEVVYHVAAIAVVYDRLQHSQRFYLGHDDDILSLAIHP 737

  Fly   538 SRELVASGQKAGRDRKSQAHVRIWSTESLQTLYVFGMGELDSGVTAVAFSQLNGGSYILAVDSGR 602
            .::.||:|| .|||    |.:.:|.|::|:.|.:. .|:...||:|:.||.  .|..:::|....
 Frog   738 VKDYVATGQ-VGRD----AAIHVWDTQTLKCLSLL-KGQHQRGVSALDFSA--DGKCLVSVGLDD 794

  Fly   603 ESILSVWQWQWGHLLGKVATLQEGLSGAAFHPLDDNLIITHGRGHLAFWHRRKDGFFERT----D 663
            ...:..|.|:.|..:......::.:.....:|...:.::|.|..|:.||.:...||..:.    .
 Frog   795 NHTIVYWDWKKGEKIACTRGHKDKIFVVKCNPHHTDKLVTVGMKHIKFWQQTGGGFTAKRGTFGT 859

  Fly   664 IVKQPSRSHVTSVQFEPDGD-VITADSDGFITIYSVDSDGAYFVRTEFEAHNKGIGCLIMLGEGT 727
            |.|..:...|:..:.|   | |.:..:.|.|.|:.    ....::| .:||:..:..:..|.:|
 Frog   860 IGKLETMMCVSYGRAE---DLVFSGAATGDIYIWK----DVVLLKT-IKAHDGPVFAMYALDKG- 915

  Fly   728 LLSGGEKDRKIAAWDS-----LQNYKKIADTKLPEAAG-------GVRTIYPQRPGRNDGNIYVG 780
            .::|| ||..:..||.     |:.|........|.:.|       .:|.|     ....|:|.||
 Frog   916 FVTGG-KDGVVELWDDMFERCLKTYAIKRAALSPSSKGLLLEDNPSIRAI-----TLGHGHILVG 974

  Fly   781 TTRNNILEGSLQRRFTQVVFGHGR-QLWGLAAHPDDELYATAGHDKHVALWRKNK-----LIWTI 839
            |....|||.......|.:|.||.. ::||||.||...|.||...||.:.:|..:.     .:..:
 Frog   975 TKNGEILEIDKSGPMTLLVQGHMEGEVWGLATHPQLPLCATVSDDKTLRIWELSSQHRMLAVRKL 1039

  Fly   840 QTGYECVALAFHPFG-TLAAGSTEGHLLVINCENGAVMLTLRVCGSPLNCVAYNQVGDMIA--MG 901
            :.|..|  .||.|.| .||.|.::|..||:|.:      ||.      :.|:::...::||  ..
 Frog  1040 KKGGRC--CAFSPDGKALAVGLSDGSFLVVNAD------TLE------DMVSFHHRKEIIADIKF 1090

  Fly   902 SQNGSIYLFRVSRDGF-------SYKKVNKIRG-SQPLTHLDWSMDGNFVQTVTIDFDLLFWDAK 958
            |.:...||...|.|.|       |.|:|...:| |..:||:||...|..:|..:...:.||::|.
 Frog  1091 SPDAGKYLAVASHDNFVDIYNVLSSKRVGICKGASSYITHIDWDTRGKLLQVNSGAKEQLFYEAP 1155

  Fly   959 SLSPERSPI---AMKDVKWLTNNCTVGFLVAGQW-SNRYYSTTNTIVATCSRSAAHDMLASGDAE 1019
              ..:|..|   .|:.::|.|..|.:|....|.| ::...:..|....|..|.|    ||:||..
 Frog  1156 --RGKRYVIKAAEMEKIEWHTWTCVLGPTCEGIWPAHSDITDVNAASLTKDRKA----LATGDDF 1214

  Fly  1020 GYLRLFRYPCISPRAEFHESKVYSGMLACVRFLCGDHTLITVGGTDASLMVW 1071
            |:::||.||.....|:|.:...:|..:..||:|..|.||:||||.|.:||:|
 Frog  1215 GFVKLFSYPVKGCDAKFKKYVGHSAHVTNVRWLYDDSTLLTVGGADTALMIW 1266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCX-EMAP	NP_001261850.1	DCX	166..253	CDD:214711
		DCX2_RP_like	300..372	CDD:340590
		HELP	449..515	CDD:460922	22/41 (54%)
		WD40	520..562	CDD:459801	17/41 (41%)
		WD40 repeat	530..573	CDD:293791	15/42 (36%)
		WD40	548..959	CDD:441893	115/444 (26%)
		WD40 repeat	582..624	CDD:293791	8/41 (20%)
		WD40 repeat	627..664	CDD:293791	8/40 (20%)
		WD40 repeat	673..712	CDD:293791	8/39 (21%)
		WD40 repeat	718..801	CDD:293791	24/94 (26%)
		WD40 repeat	806..838	CDD:293791	12/36 (33%)
		WD40 repeat	846..880	CDD:293791	12/34 (35%)
		WD40	847..>1073	CDD:475233	75/240 (31%)
		WD40 repeat	886..918	CDD:293791	9/40 (23%)
		WD40 repeat	931..969	CDD:293791	11/40 (28%)
		WD40 repeat	1002..1037	CDD:293791	13/34 (38%)
eml6	XP_031758938.1	HELP	<2..48	CDD:460922
		WD40	57..438	CDD:441893
		WD40 repeat	64..103	CDD:293791
		WD40 repeat	110..148	CDD:293791
		WD40 repeat	153..191	CDD:293791
		WD40 repeat	199..233	CDD:293791
		WD40 repeat	240..275	CDD:293791
		WD40 repeat	286..321	CDD:293791
		WD40 repeat	328..352	CDD:293791
		WD40 repeat	369..401	CDD:293791
		WD40 repeat	410..449	CDD:293791
		WD40 repeat	521..560	CDD:293791
		HELP	<665..715	CDD:460922	22/41 (54%)
		WD40	725..1066	CDD:238121	97/365 (27%)
		WD40 repeat	730..768	CDD:293791	15/43 (35%)
		WD40 repeat	775..816	CDD:293791	9/42 (21%)
		WD40 repeat	822..861	CDD:293791	8/38 (21%)
		WD40 repeat	866..898	CDD:293791	7/38 (18%)
		WD40	880..1266	CDD:441893	120/417 (29%)
		WD40 repeat	910..994	CDD:293791	23/90 (26%)
		WD40 repeat	941..992	CDD:293791	13/55 (24%)
		WD40 repeat	1001..1041	CDD:293791	12/39 (31%)
		WD40 repeat	1044..1080	CDD:293791	15/49 (31%)
		WD40 repeat	1085..1122	CDD:293791	11/36 (31%)
		WD40 repeat	1129..1174	CDD:293791	13/46 (28%)
		WD40 repeat	1196..1235	CDD:293791	15/42 (36%)
		WD40 repeat	1241..1268	CDD:293791	14/26 (54%)
		HELP	<1405..1445	CDD:460922
		WD40	<1445..1584	CDD:475233
		WD40 repeat	1517..1555	CDD:293791
		WD40	1522..2007	CDD:441893
		WD40 repeat	1560..1602	CDD:293791
		WD40 repeat	1610..1642	CDD:293791
		WD40 repeat	1649..1692	CDD:293791
		WD40 repeat	1741..1778	CDD:293791
		WD40 repeat	1782..1819	CDD:293791
		WD40 repeat	1824..1860	CDD:293791
		WD40 repeat	1870..1916	CDD:293791
		WD40 repeat	1936..1973	CDD:293791