DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17839 and bt

DIOPT Version :9

Sequence 1:	NP_996085.2	Gene:	CG17839 / 39616	FlyBaseID:	FBgn0036454	Length:	1656	Species:	Drosophila melanogaster
Sequence 2:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster

Alignment Length:	1932	Identity:	352/1932 - (18%)
Similarity:	562/1932 - (29%)	Gaps:	740/1932 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VKCGVPIG-----TGGPSIILESKDALLTCVVSDNSSNNTVIWKKGDEILTAGTVRVTKDHRVRI 78
            |:.|.|:.     :|.|:                    .|:.||:||
  Fly  6177 VRAGEPVNLNIPISGAPT--------------------PTIEWKRGD------------------ 6203

  Fly    79 LHDENPKGKNLETGGEVWVLLIKTLKPNDSGAYIC----ELNSDPVLRSIHILTVKELHSSTGGP 139
            |..|..|..:.||..|..:..|......|||.|..    |...|..  .|.::.| :..|...||
  Fly  6204 LKLEEGKRISYETNSERTLFRIDDSNRRDSGKYTVTAANEFGKDTA--DIEVIVV-DKPSPPEGP 6265

  Fly   140 GNSTDTSTAESSDVFLLPPPLDAQDNRSFWRPSQVPPLVTHDFTECCERANVSTQCMGFCNVHNI 204
            .:.|:|:....|..:..|......|...:          ..:|||
  Fly  6266 LSYTETAPDHISLHWYSPKDDGGSDITGY----------IIEFTE-------------------- 6300

  Fly   205 LDGTTGIDPEACERDFPGIVRCMADGRNHVPCCVDKQIPDLCQDMCRGEYTPFTDK--------- 260
                .|:|      |:                   |.:|..|.:      |.||.|
  Fly  6301 ----FGVD------DW-------------------KPVPGTCPN------TNFTVKNLVEGKKYV 6330

  Fly   261 LKTRVSCV---QHTLSGLQCILKGVQLIPSSPTFVTIENVSETSVTIGWTAPDKLADR-VSGYTI 321
            .:.|...:   ...|.|...:.|.....|.:|:..||...:..|..:.|..||....: ::||.:
  Fly  6331 FRIRAENIYGASEALEGKPVLAKSPFDPPGAPSQPTISAYTPNSANLEWHPPDDCGGKPITGYIV 6395

  Fly   322 NLTTLHSFDEDELSGEIVHRTASDSPESISLYSVPTNQTQLTLSNLSPLTMYAVIVTATNEFGSS 386
                    :..|..|           |.|...:.||..|..|:|||.....|...|.|.||.|..
  Fly  6396 --------ERRERGG-----------EWIKCNNYPTPNTSYTVSNLRDGARYEFRVLAVNEAGPG 6441

  Fly   387 LPTERLRFFTHTSASAAESKAGTTDKQAMPQLPD--TRQCCEDNGMTHRMCLDKMCDPQKTD-QA 448
            .|::      .:....||.:....|....|: ||  ||     ||:|      ....|.:|| ::
  Fly  6442 HPSK------PSDPMTAEHQRYRPDPPEPPK-PDRITR-----NGVT------LSWRPPRTDGKS 6488

  Fly   449 NLPDFMV-CAP-----WSNI---------------------TFNCLANN---------------I 471
            .:..:.| ..|     |..:                     :|..:|.|               |
  Fly  6489 RIKGYYVEMRPKNGKDWKTVNDIPINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPSKPSQPITI 6553

  Fly   472 DHTPCCRARGIPSACFPLCAGKLTSL------DFSLFKCLRFMSEYNSCLFQGYGVLAD------ 524
            :..|       ...|..|  ||:..:      |||:........:.|:..:....:|.|
  Fly  6554 EEQP-------NKPCMEL--GKVRDIVCRAGDDFSIHVPYLAFPKPNAFWYSNDNMLDDNNRVHK 6609

  Fly   525 ----------------------------------------------PPSKLRTVAKTDSFVILDW 543
                                                          ||::||....:...:.|.|
  Fly  6610 HLTDDAASVVVKNSKRADSGQYRLQLKNTSGFDTATINVRVLDRPSPPTRLRADEFSGDSLTLYW 6674

  Fly   544 NKPKRLADTVSTYHVKFRRLGVGDD-------YLTVEKRQ---------------PPLILEGLES 586
            |.|                   .||       |: :||::               |.:.:..|..
  Fly  6675 NPP-------------------NDDGGSAIQNYI-IEKKEARSSTWSKVSSFCTVPFVRIRNLVL 6719

  Fly   587 DIYYEFYVVSINAYGKSEASPRLITRTLPAEPVQQTAARY------------------NMTTCCQ 633
            :..|:|.|::.|.||:|:          ||...:...||:                  :..|...
  Fly  6720 NKEYDFRVIAENKYGQSD----------PANTSEPILARHPFDIPNTPGIPHGIDSTEDSITIAW 6774

  Fly   634 ASGLLPQCAPLCSYNIR---LSD------IERLGPACRAQMPILARCAAGGRDHSPCCSRRGVIN 689
            ........:|:..|.|.   |||      :..|.|....::|.|.       :::....|...:|
  Fly  6775 TKPKHDGGSPITGYIIEKRLLSDDKWTKAVHALCPDLSCKIPNLI-------ENAEYEFRVAAVN 6832

  Fly   690 ACMPLCRGVMPLALTTKSSSASAAAAATSSSSG---------ATAATS-ASATSNSNAAG----- 739
            |                     |..:|.|.||.         |...|| .|....:..||
  Fly  6833 A---------------------AGQSAYSGSSDLIFCRRPPHAPKITSDLSIRDMTVIAGDEFRI 6876

  Fly   740 -APSSSSSSASSGTSSNVPDCLSYAGNILQCFEEGTQNIPG-----PPEDVHATFVNQSSVSLAW 798
             .|..:|...::..|.|                 |.:.|||     ...|..:.:.|:|:.....
  Fly  6877 TVPYHASPRPTASWSLN-----------------GLEVIPGERIKFDSNDYASMYYNKSAKRDET 6924

  Fly   799 TQPDVDNSNSSSSGNASPGDMITGDELAAGAVDPANAGKDVPNAGDATSGTT-----------GT 852
            ....:..:|:..|..||         .....||.....:...||.|.|..|.           |:
  Fly  6925 GSYTITLTNNKGSDTAS---------CHVTVVDRPLPPQGPLNAYDITPDTCTLAWKTPLDDGGS 6980

  Fly   853 EDIEFIVQYGKVNNMTMYETVAKLENELTTNETSIDLTNLDANALYRITVVTRGKFGTSLPASML 917
            ....::|:  |::|...:..::..     ...|..|:..|:.:..|...|....::|.|.|..::
  Fly  6981 PITNYVVE--KLDNSGSWVKISSF-----VRNTHYDVMGLEPHYKYNFRVRAENQYGLSDPLDII 7038

  Fly   918 LLNTTDQQRTGEAWGAPSPPHSLTVVAHSATWMQLTWQPPEYAHPHERIT-YRVYHK------AM 975
            .......|.|     .|..|....|:...:..:.|.|..| .:....||. |::.::      :.
  Fly  7039 EPIVAKHQFT-----VPDEPGQPKVIDWDSGNVTLIWTRP-LSDGGSRIQGYQIEYRDILNDSSW 7097

  Fly   976 RAEQFIKIETKLAWLRMNNLKPSSQHVLYVEAVGERGDSLPSETLV------AWTDPALPA---- 1030
            .|..:|..:||   .::.||...|::...::|....|.|.||...:      .:|.|:.|.
  Fly  7098 NAYDYIIKDTK---YQLYNLINGSEYEFRIKAKNAAGLSKPSSPSLRFKLKGKFTVPSPPGAPQV 7159

  Fly  1031 ------FVDPPTVHPADNIPEGGSMTILCLAFGNPAPTISLYVGGHLV-RQDASRHM-------- 1080
                  :||.....|   :.:|||.                 :.|::: |:|....:
  Fly  7160 TRVGKNYVDLKWEKP---LRDGGSR-----------------ITGYIIERRDIGGAVWVKCNDYN 7204

  Fly  1081 -----VTVIHNVSADMEHVSCYADN--GYGVPMQATRRVNIC------YPPKIQAAGITVANIGD 1132
                 .||::.:.........:|.|  |...|...|..:.:|      .|..|......||..|.
  Fly  7205 VLDTEYTVMNLIEMGDYEFRVFAVNSAGRSEPSLCTMPIKVCEVLGGKKPDWITRLQDKVAPFGK 7269

  Fly  1133 EIELRCTVDSKPAPKTIFWREKDGRVPVINGGNYFISVKANESRPSIYTMSLRISKLQANDVGDY 1197
            :..|:|....||:| |..|. ::|:...:|||.     ...:|:..::  .|.||.:|..|.|||
  Fly  7270 DYTLQCAASGKPSP-TARWL-RNGKEIQMNGGR-----MTCDSKDGVF--RLHISNVQTGDDGDY 7325

  Fly  1198 FCHADNPFGATTTPVSVRIRNTPALNHNVSE----------------------CCAAQNVSMACR 1240
            .|.|.|..|...|...::|.:.|.:|...||                      ....:|..:.|.
  Fly  7326 TCEAMNSLGFVNTSGYLKIGSPPIINRCPSELKLPEGDNSKIKIFYSGDQPLTVILKKNNEVICD 7390

  Fly  1241 SACSYYV------DFDAIADRPECIVDFDKLMRCAADGSDHRSCCADE----------HV----- 1284
            |....:|      |:.||..|.  ||        .:||..::....:|          |:
  Fly  7391 SNDDTHVKVNIFDDYVAIYIRN--IV--------KSDGGPYQIEFTNESGSATGEFYVHITGMPS 7445

  Fly  1285 ------------PRKC-LNWCRGES-----------VRSKEICSLQY----------ARTIVGCF 1315
                        ...| ||| |..|           :..|::.|..:          |..:.|..
  Fly  7446 APTGPMGISYINKNSCMLNW-RPPSYDGGLKVSHYVIERKDVSSPHWITVSSTCKDTAFNVQGLI 7509

  Fly  1316 E--------------------------KNRDRL--PGPPENIVVSVVSDSEVNVRWDAPTKNPNA 1352
            |                          :.:|.:  |.||.:..::.:....|::.|:.|..:..|
  Fly  7510 ENQEYIFRVMAVNENGMGPPLEGLNPIRAKDPIDPPSPPGSPQITEIGGDFVHLEWEKPESDGGA 7574

  Fly  1353 -VDGYRIFYHEAAILPPTSSSSSGSPSSDSGSSMENPGMDTLAAMNNATSMGNSNNAMAALEIRR 1416
             :.||.|...|.                         |.:|...:|......|..|.:..:|.|:
  Fly  7575 HIQGYWIDKREV-------------------------GSNTWQRVNATICAANQINCINLIEGRQ 7614

  Fly  1417 IDVKDTTISINGLKKDVLYELVVKAGNSYGASVLTDPIRFTLGEHHVTSATSSYSSAVGTISGIV 1481
                              ||..:.|.|..|                 .|..||.|.||..|....
  Fly  7615 ------------------YEFRIFAQNVAG-----------------LSTESSASQAVKIIDPQA 7644

  Fly  1482 ASILAILLAAAAIVFYRRQRSSYGKSANGNVAFENPTYTRGLEQVQLPTVT---SAITTQNGNHH 1543
            ||...|:...              :.|| .:...|..:|..:..|..||::   .|....||..:
  Fly  7645 ASPPLIVKPL--------------RDAN-CIQNHNAQFTCTINGVPKPTISWYKGAREISNGARY 7694

  Fly  1544 GMSSSNNNGSSN-------------SHSHGRNGIAATMTTSTTTTAP 1577
            .|.|..:|...|             ..:..:.|..:|..|....|||
  Fly  7695 HMYSEGDNHFLNINDVFGEDADEYVCRAVNKAGAKSTRATLAIMTAP 7741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17839	NP_996085.2	ig	33..116	CDD:278476	17/86 (20%)
		IG_like	35..129	CDD:214653	19/97 (20%)
		DB	185..278	CDD:279948	13/104 (13%)
		FN3	286..396	CDD:238020	28/110 (25%)
		DB	424..515	CDD:279948	22/139 (16%)
		FN3	524..613	CDD:238020	23/162 (14%)
		DB	631..>704	CDD:279948	13/81 (16%)
		FN3	778..915	CDD:238020	28/152 (18%)
		FN3	934..1024	CDD:238020	21/102 (21%)
		Ig	1034..1104	CDD:299845	12/85 (14%)
		IG_like	1126..1216	CDD:214653	28/89 (31%)
		Ig	1134..1216	CDD:299845	25/81 (31%)
		DB	1229..1315	CDD:279948	24/140 (17%)
		FN3	1323..1457	CDD:238020	23/134 (17%)
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352	24/117 (21%)
Ig_Titin_like	6182..6255	CDD:143225	22/112 (20%)
FN3	6259..6350	CDD:238020	24/155 (15%)
FN3	6359..6451	CDD:238020	28/116 (24%)
FN3	6470..6552	CDD:238020	14/92 (15%)
I-set	6564..6650	CDD:254352	9/87 (10%)
Ig_Titin_like	6577..6650	CDD:143225	6/72 (8%)
FN3	6654..6745	CDD:238020	24/120 (20%)
FN3	6754..6840	CDD:238020	16/113 (14%)
I-set	6855..6946	CDD:254352	20/116 (17%)
Ig	6874..6946	CDD:299845	15/97 (15%)
FN3	6950..7042	CDD:238020	17/98 (17%)
FN3	7050..7139	CDD:238020	21/92 (23%)
FN3	7151..7237	CDD:238020	16/105 (15%)
I-set	7254..7334	CDD:254352	28/88 (32%)
Ig	7272..7339	CDD:143165	24/75 (32%)
IG_like	7354..7440	CDD:214653	15/95 (16%)
Ig	7366..7440	CDD:299845	13/83 (16%)
FN3	7444..7531	CDD:238020	11/87 (13%)
FN3	7545..7637	CDD:238020	27/151 (18%)
I-set	7648..7737	CDD:254352	18/103 (17%)
Ig	7665..7734	CDD:143165	13/68 (19%)
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13817
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100