|
Fly 310 DEG--RDWKWRPPPRGYT-LDTYSLCETFSEAHICHYGAQCVEAHGQDELNEWKERFEYRRMRMQ 371
||| ..|.:||||||.| .:.|:||:.|.|..||.|||||..||.|:||.||::|:..|.::::
Human 159 DEGSCNGWHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLK 223
Fly 372 KACEKELYGKSYTEQVLDRWIQATAPERVMCERVPDMEARCEQQLVTSISSKTSKREWLFQLETK 436
:..|.:....||.|.::::|:.:.:||:|:.|.:..::......|..::|:|.|.:.|.|.| |.
Human 224 QQNENKQLSGSYMETLIEKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFAL-TC 287
Fly 437 KP---LKAVALLQDAHRNHFALKSIKM-CKPTESSMELKSD-QEWLAGSSSQSETSNEDSATLIH 496
|| |..||||.||||.||::.:|.. ...|:.|.|:..: |||:.|..:|:...: .::
Human 288 KPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDH-----YVY 347
Fly 497 EITVEFHTEIYGTFRQAICFDVGQEPLLVRHLCVDVLPVNDAEKIEEIKRDIINSSATRWDVANT 561
::.:.|:|||:|||||.|.||.|.||:|::.:.:|.....|.|.:...|:.:: ::|.|||.::.
Human 348 KVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLV-TTAKRWDSSSK 411
Fly 562 QLTRFETTIGTHLKTEAYLSDLEHERELLERYPCPRAATFTLTQSTIVEKRLTQNNYRSRIHELL 626
.:..||....|.| |:.||.||..|.:|....||| :::|.||::||:||:|:||
Human 412 TIIDFEPNETTDL-----------EKSLLIRYQIPLSADQLFTQS-VLDKSLTKSNYQSRLHDLL 464
Fly 627 SVEEIARYEQIAR---------------------------YNVRTRLTVASNYILTPAGMATSTA 664
.:||||:|::|:. :|::.:|.:.::::||. .:..|
Human 465 YIEEIAQYKEISNTSGASTSRILLQDTTNVTRGFSCCSKLFNLKVQLQILASFMLTG---VSGGA 526
Fly 665 KYSLAGELFALMRLGKDISEDTSPGRLILSNCSSVY-ISKPEDPDSKADPTKRAVYEALIEDKGK 728
||:..|:||...:|.:.:||||..|||:::..::|| :..|:....:...||..||||.||:|.|
Human 527 KYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTK 591
Fly 729 NVIYLKLSAKCVEAMALQADTELEVDIQFQLNRMPYCEWHNAVDKITDFRLIFPATELEPSIPWT 793
..|:|:||.:|.|.:.|:.|.:.:|::||||||:|.||.|.|:|:|.|..::||...:.|:|||:
Human 592 EYIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWS 656
Fly 794 PKKQWADSCEPKLNAKQREAVNAITTALSIKLPPILLIGPFGTGKTYTLAQAIKQLLTQPE-AKI 857
|.:||.:..:|:|||||:|||.||||.|:|:|||:|:|||:|||||:|||||:|.:|.|.| ::|
Human 657 PNRQWDEQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETSRI 721
Fly 858 LICTHSNSAADLYIKEYLHPWIEEGLKEATPLRVYYHKRWSATVNGVVQKYC-ITDGVGNFLRPT 921
|||||||||||||||:||||::|.|..:|.|||||:..||..||:.||.:|| |:.....|..|.
Human 722 LICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQ 786
Fly 922 VEDIMRHRIVVVTLSISMELATLGLPKGLFTHIFLDEAAQAMECEAIMPLALANDSTRIVLAGDH 986
.|||::||:|||||:.|..|..|.|..|.||||.|||||||||||.|||||||..:|||||||||
Human 787 KEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDH 851
Fly 987 MQMSPELFSAFAKERKLHISLLERLYDHYPSNFPCKILLCENYRAHEAIIRFTSELFYEQKLVAS 1051
||:||.::|.||:||.||:|||:|||:|||:.|||:||||||||:|||||.:|||||||.||:||
Human 852 MQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMAS 916
Fly 1052 GKQPRHDRFYPLTFFTTRGEDVQDKNSTAFYNNAEVYEVVERVSELRKRWPSAWGKLNDTSIGIM 1116
||||.|..||||||||.||||||:||||||||||||:||||||.|||::||.|||||:|.|||::
Human 917 GKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVV 981
Fly 1117 TPYSDQVFRIRSELRKRRMGGISVERVLNVQGKQFRAVFLSTVRTRRTCMPQGSAPGSASTTSIG 1181
|||:|||||||:||||:|:..::|||||||||||||.:||||||||.||..: ..|.......:.
Human 982 TPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHK-QTPIKKKEQLLE 1045
Fly 1182 DA--DADYGFLSNSKLLNTAITRAQSLVAVVGDPVALCSIGRCRKVWERFIEICDEHKSLFGLTW 1244
|: |.|||||||.||||||||||||||||||||:||||||||||.|||||.:|.|:.||.|:|:
Human 1046 DSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSLHGITF 1110
Fly 1245 SNLRSQLDGVELKRGYVLNPLAPEFVPRA--LQPEAYLREQAALYLNGPQHGHGGHGPPGPPAHF 1307
..:::||:.:|||:.||||||||||:||| ||......:|. ..|..|...|..... ||
Human 1111 EQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQ----QSPPKGKSLHHTQND--HF 1169
Fly 1308 ANAAGMLGPGPAAAAHQMNQMAAAMAANQQQLTAHMYSTHMAMMAAAVGGKSGNGPGPGTGGGPG 1372
.| .|::.|.|:.... |.:.| |:....: ||.|..|..|.
Human 1170 QN-DGIVQPNPSVLIG--NPIRA-------------YTPPPPL-----------GPHPNLGKSPS 1207
Fly 1373 PGPGPPPHYGGG-----GGGGGHMGMRGPPPPAP----------------HLRGMP--------- 1407
|.....||.|.. ...||::.| ..|.|.| |...|.
Human 1208 PVQRIDPHTGTSILYVPAVYGGNVVM-SVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTH 1271
Fly 1408 -PGGPPPTQQPGGAGGGGGPPPPYGQYPAMQHWRPPQQGQNQG-----------------PGQQP 1454
.|.|.| .|.|..||...|| |..||....|..||:. |.::|
Human 1272 GRGSPIP------YGLGHHPPVTIGQ-PQNQHQEKDQHEQNRNGKSDTNNSGPEINKIRTPEKKP 1329
Fly 1455 PQNPNASLWGPP----PQTNPWSVLPPSKQPQQ----------PQPPP---VSAPGRGPGPLPPP 1502
.:.....|...| |::.|..|.|.:|.|:: |.|.| .:.|.|...|||.
Human 1330 TEPKQVDLESNPQNRSPESRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQYAIPNRHFHPLPQ- 1393
Fly 1503 LNANPSLPLRGGSVPPPPPNASTAAHLLRNPSELGYLAKKSLYNHGQALPH--HQLYGPGPGPPP 1565
.|.||......|.|.|..: ..||. :|: ||
Human 1394 --------------LPRPPFPIPQQHTLLNQQQ-------------NNLPEQPNQI-------PP 1424
Fly 1566 PPSQ---------QQPQAPPMGMQRGSSVPNGPMSPMENGPPPPPYLRHNGSGYNPGAPPPP--- 1618
.|:| ||||.|| |. :||.....|...:. ::...:.|.:||..
Human 1425 QPNQVVQQQSQLNQQPQQPP---------PQ--LSPAYQAGPNNAFF-NSAVAHRPQSPPAEAVI 1477
Fly 1619 PQQQPQPPPNPFMYAGKQPSPSSMRFGPMTHELLPPNVSIYDMAFNPKDEQYKWYVKLLETVGQD 1683
|:|||. |.:..|..|..:..:.|| :||.:::.: :..||.. :.:.|.:.:.
Human 1478 PEQQPP----PMLQEGHSPLRAIAQPGP----ILPSHLNSF-IDENPSG------LPIGEALDRI 1527
Fly 1684 GANKFAEMLRQVMATMQQQQQQHKPPQPPMANNPMLNNPHVQR-PQYPMMYPQGQQQQQQQPPQQ 1747
..:...|.|||..|..||..:.|.......|..|..::||:|. ||.|: ...|||
Human 1528 HGSVALETLRQQQARFQQWSEHHAFLSQGSAPYPHHHHPHLQHLPQPPL--------GLHQPP-- 1582
Fly 1748 SVDASPPL-ENFNQQIDLVFNSIMNGANDVAQPILRDVLGMVAGTGNAPGPPLSNGLNGVDLQQQ 1811
|.|...| .:...:::..::.. |.::|::
Human 1583 -VRADWKLTSSAEDEVETTYSRF--------QDLIREL--------------------------- 1611
Fly 1812 QQQQQQQQQSRLFAMMQQQQ----QQQQQQQAKPPLGPGP------------------------- 1847
..:.|.::|..|.|...| |.:|.|...||..|.|
Human 1612 --SHRDQSETRELAEMPPPQSRLLQYRQVQSRSPPAVPSPPSSTDHSSHFSNFNDNSRDIEVASN 1674
Fly 1848 -----------------LYPNHLGGPGLHQAPPNGGGNLSGVGNTNFMGNA---GNALLNDKPYN 1892
|...||..|.|....|:|....:.:...:.||.. |...|..:|..
Human 1675 PAFPQRLPPQIFNSPFSLPSEHLAPPPLKYLAPDGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQ 1739
Fly 1893 N--VGMHNNVGLNIGGAGVAGHNSNNNNGMLTNGNNSV-------------PLYRRQAHTGNGIG 1942
| |.:.|: ....|....:.....|..::|: |||:|:. :.:.:.
Human 1740 NPFVQIQNH-------QHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRI-SSSSVQ 1796
Fly 1943 GGNGDYNNMHGMDAGANLIEALFQANNSVVDHSVKSS----------DHMHGLLYNNF--NG--- 1992
..:.:.:... ::|.|. ..:.|||.:|| :......|.|. ||
Human 1797 PCSEEVSTPQ---------DSLAQC-KELQDHSNQSSFNFSSPESWVNTTSSTPYQNIPCNGSSR 1851
Fly 1993 --------------------LKGGGHE------------LDLFQAMAPSVPHSEAANHHQ-QSS- 2023
||....| |..|..:.|:...:|:||... |||
Human 1852 TAQPRELIAPPKTVKPPEDQLKSENLEVSSSFNYSVLQHLGQFPPLMPNKQIAESANSSSPQSSA 1916
Fly 2024 -GSSATTYAAVLSQGPQAVVGGGVGTGPSPGQSQAQAGVAGSGTGGKVAPAVGRNDLLEKDPFAA 2087
|..|.:||:.|...|: |.|...||:. ..||.:.
Human 1917 GGKPAMSYASALRAPPK----------PRPPPEQAKK---------------------SSDPLSL 1950
Fly 2088 IREL----GQATTGFYNYFQ 2103
.:|| ...:.|||:||:
Human 1951 FQELSLGSSSGSNGFYSYFK 1970
| 
