DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Helz and HELZ

DIOPT Version :9

Sequence 1:NP_001261848.1 Gene:Helz / 39613 FlyBaseID:FBgn0036451 Length:2103 Species:Drosophila melanogaster
Sequence 2:XP_006722277.1 Gene:HELZ / 9931 HGNCID:16878 Length:1970 Species:Homo sapiens


Alignment Length:2035 Identity:719/2035 - (35%)
Similarity:1005/2035 - (49%) Gaps:464/2035 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   310 DEG--RDWKWRPPPRGYT-LDTYSLCETFSEAHICHYGAQCVEAHGQDELNEWKERFEYRRMRMQ 371
            |||  ..|.:||||||.| .:.|:||:.|.|..||.|||||..||.|:||.||::|:..|.::::
Human   159 DEGSCNGWHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLK 223

  Fly   372 KACEKELYGKSYTEQVLDRWIQATAPERVMCERVPDMEARCEQQLVTSISSKTSKREWLFQLETK 436
            :..|.:....||.|.::::|:.:.:||:|:.|.:..::......|..::|:|.|.:.|.|.| |.
Human   224 QQNENKQLSGSYMETLIEKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFAL-TC 287

  Fly   437 KP---LKAVALLQDAHRNHFALKSIKM-CKPTESSMELKSD-QEWLAGSSSQSETSNEDSATLIH 496
            ||   |..||||.||||.||::.:|.. ...|:.|.|:..: |||:.|..:|:...:     .::
Human   288 KPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDH-----YVY 347

  Fly   497 EITVEFHTEIYGTFRQAICFDVGQEPLLVRHLCVDVLPVNDAEKIEEIKRDIINSSATRWDVANT 561
            ::.:.|:|||:|||||.|.||.|.||:|::.:.:|.....|.|.:...|:.:: ::|.|||.::.
Human   348 KVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLV-TTAKRWDSSSK 411

  Fly   562 QLTRFETTIGTHLKTEAYLSDLEHERELLERYPCPRAATFTLTQSTIVEKRLTQNNYRSRIHELL 626
            .:..||....|.|           |:.||.||..|.:|....||| :::|.||::||:||:|:||
Human   412 TIIDFEPNETTDL-----------EKSLLIRYQIPLSADQLFTQS-VLDKSLTKSNYQSRLHDLL 464

  Fly   627 SVEEIARYEQIAR---------------------------YNVRTRLTVASNYILTPAGMATSTA 664
            .:||||:|::|:.                           :|::.:|.:.::::||.   .:..|
Human   465 YIEEIAQYKEISNTSGASTSRILLQDTTNVTRGFSCCSKLFNLKVQLQILASFMLTG---VSGGA 526

  Fly   665 KYSLAGELFALMRLGKDISEDTSPGRLILSNCSSVY-ISKPEDPDSKADPTKRAVYEALIEDKGK 728
            ||:..|:||...:|.:.:||||..|||:::..::|| :..|:....:...||..||||.||:|.|
Human   527 KYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTK 591

  Fly   729 NVIYLKLSAKCVEAMALQADTELEVDIQFQLNRMPYCEWHNAVDKITDFRLIFPATELEPSIPWT 793
            ..|:|:||.:|.|.:.|:.|.:.:|::||||||:|.||.|.|:|:|.|..::||...:.|:|||:
Human   592 EYIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWS 656

  Fly   794 PKKQWADSCEPKLNAKQREAVNAITTALSIKLPPILLIGPFGTGKTYTLAQAIKQLLTQPE-AKI 857
            |.:||.:..:|:|||||:|||.||||.|:|:|||:|:|||:|||||:|||||:|.:|.|.| ::|
Human   657 PNRQWDEQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETSRI 721

  Fly   858 LICTHSNSAADLYIKEYLHPWIEEGLKEATPLRVYYHKRWSATVNGVVQKYC-ITDGVGNFLRPT 921
            |||||||||||||||:||||::|.|..:|.|||||:..||..||:.||.:|| |:.....|..|.
Human   722 LICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQ 786

  Fly   922 VEDIMRHRIVVVTLSISMELATLGLPKGLFTHIFLDEAAQAMECEAIMPLALANDSTRIVLAGDH 986
            .|||::||:|||||:.|..|..|.|..|.||||.|||||||||||.|||||||..:|||||||||
Human   787 KEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDH 851

  Fly   987 MQMSPELFSAFAKERKLHISLLERLYDHYPSNFPCKILLCENYRAHEAIIRFTSELFYEQKLVAS 1051
            ||:||.::|.||:||.||:|||:|||:|||:.|||:||||||||:|||||.:|||||||.||:||
Human   852 MQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMAS 916

  Fly  1052 GKQPRHDRFYPLTFFTTRGEDVQDKNSTAFYNNAEVYEVVERVSELRKRWPSAWGKLNDTSIGIM 1116
            ||||.|..||||||||.||||||:||||||||||||:||||||.|||::||.|||||:|.|||::
Human   917 GKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVV 981

  Fly  1117 TPYSDQVFRIRSELRKRRMGGISVERVLNVQGKQFRAVFLSTVRTRRTCMPQGSAPGSASTTSIG 1181
            |||:|||||||:||||:|:..::|||||||||||||.:||||||||.||..: ..|.......:.
Human   982 TPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHK-QTPIKKKEQLLE 1045

  Fly  1182 DA--DADYGFLSNSKLLNTAITRAQSLVAVVGDPVALCSIGRCRKVWERFIEICDEHKSLFGLTW 1244
            |:  |.|||||||.||||||||||||||||||||:||||||||||.|||||.:|.|:.||.|:|:
Human  1046 DSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSLHGITF 1110

  Fly  1245 SNLRSQLDGVELKRGYVLNPLAPEFVPRA--LQPEAYLREQAALYLNGPQHGHGGHGPPGPPAHF 1307
            ..:::||:.:|||:.||||||||||:|||  ||......:|.    ..|..|...|.....  ||
Human  1111 EQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQ----QSPPKGKSLHHTQND--HF 1169

  Fly  1308 ANAAGMLGPGPAAAAHQMNQMAAAMAANQQQLTAHMYSTHMAMMAAAVGGKSGNGPGPGTGGGPG 1372
            .| .|::.|.|:....  |.:.|             |:....:           ||.|..|..|.
Human  1170 QN-DGIVQPNPSVLIG--NPIRA-------------YTPPPPL-----------GPHPNLGKSPS 1207

  Fly  1373 PGPGPPPHYGGG-----GGGGGHMGMRGPPPPAP----------------HLRGMP--------- 1407
            |.....||.|..     ...||::.| ..|.|.|                |...|.         
Human  1208 PVQRIDPHTGTSILYVPAVYGGNVVM-SVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTH 1271

  Fly  1408 -PGGPPPTQQPGGAGGGGGPPPPYGQYPAMQHWRPPQQGQNQG-----------------PGQQP 1454
             .|.|.|      .|.|..||...|| |..||....|..||:.                 |.::|
Human  1272 GRGSPIP------YGLGHHPPVTIGQ-PQNQHQEKDQHEQNRNGKSDTNNSGPEINKIRTPEKKP 1329

  Fly  1455 PQNPNASLWGPP----PQTNPWSVLPPSKQPQQ----------PQPPP---VSAPGRGPGPLPPP 1502
            .:.....|...|    |::.|..|.|.:|.|::          |.|.|   .:.|.|...|||. 
Human  1330 TEPKQVDLESNPQNRSPESRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQYAIPNRHFHPLPQ- 1393

  Fly  1503 LNANPSLPLRGGSVPPPPPNASTAAHLLRNPSELGYLAKKSLYNHGQALPH--HQLYGPGPGPPP 1565
                          .|.||......|.|.|..:             ..||.  :|:       ||
Human  1394 --------------LPRPPFPIPQQHTLLNQQQ-------------NNLPEQPNQI-------PP 1424

  Fly  1566 PPSQ---------QQPQAPPMGMQRGSSVPNGPMSPMENGPPPPPYLRHNGSGYNPGAPPPP--- 1618
            .|:|         ||||.||         |.  :||.....|...:. ::...:.|.:||..   
Human  1425 QPNQVVQQQSQLNQQPQQPP---------PQ--LSPAYQAGPNNAFF-NSAVAHRPQSPPAEAVI 1477

  Fly  1619 PQQQPQPPPNPFMYAGKQPSPSSMRFGPMTHELLPPNVSIYDMAFNPKDEQYKWYVKLLETVGQD 1683
            |:|||.    |.:..|..|..:..:.||    :||.:::.: :..||..      :.:.|.:.:.
Human  1478 PEQQPP----PMLQEGHSPLRAIAQPGP----ILPSHLNSF-IDENPSG------LPIGEALDRI 1527

  Fly  1684 GANKFAEMLRQVMATMQQQQQQHKPPQPPMANNPMLNNPHVQR-PQYPMMYPQGQQQQQQQPPQQ 1747
            ..:...|.|||..|..||..:.|.......|..|..::||:|. ||.|:        ...|||  
Human  1528 HGSVALETLRQQQARFQQWSEHHAFLSQGSAPYPHHHHPHLQHLPQPPL--------GLHQPP-- 1582

  Fly  1748 SVDASPPL-ENFNQQIDLVFNSIMNGANDVAQPILRDVLGMVAGTGNAPGPPLSNGLNGVDLQQQ 1811
             |.|...| .:...:::..::..        |.::|::                           
Human  1583 -VRADWKLTSSAEDEVETTYSRF--------QDLIREL--------------------------- 1611

  Fly  1812 QQQQQQQQQSRLFAMMQQQQ----QQQQQQQAKPPLGPGP------------------------- 1847
              ..:.|.::|..|.|...|    |.:|.|...||..|.|                         
Human  1612 --SHRDQSETRELAEMPPPQSRLLQYRQVQSRSPPAVPSPPSSTDHSSHFSNFNDNSRDIEVASN 1674

  Fly  1848 -----------------LYPNHLGGPGLHQAPPNGGGNLSGVGNTNFMGNA---GNALLNDKPYN 1892
                             |...||..|.|....|:|....:.:...:.||..   |...|..:|..
Human  1675 PAFPQRLPPQIFNSPFSLPSEHLAPPPLKYLAPDGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQ 1739

  Fly  1893 N--VGMHNNVGLNIGGAGVAGHNSNNNNGMLTNGNNSV-------------PLYRRQAHTGNGIG 1942
            |  |.:.|:       ....|....:.....|..::|:             |||:|:. :.:.:.
Human  1740 NPFVQIQNH-------QHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRI-SSSSVQ 1796

  Fly  1943 GGNGDYNNMHGMDAGANLIEALFQANNSVVDHSVKSS----------DHMHGLLYNNF--NG--- 1992
            ..:.:.:...         ::|.|. ..:.|||.:||          :......|.|.  ||   
Human  1797 PCSEEVSTPQ---------DSLAQC-KELQDHSNQSSFNFSSPESWVNTTSSTPYQNIPCNGSSR 1851

  Fly  1993 --------------------LKGGGHE------------LDLFQAMAPSVPHSEAANHHQ-QSS- 2023
                                ||....|            |..|..:.|:...:|:||... ||| 
Human  1852 TAQPRELIAPPKTVKPPEDQLKSENLEVSSSFNYSVLQHLGQFPPLMPNKQIAESANSSSPQSSA 1916

  Fly  2024 -GSSATTYAAVLSQGPQAVVGGGVGTGPSPGQSQAQAGVAGSGTGGKVAPAVGRNDLLEKDPFAA 2087
             |..|.:||:.|...|:          |.|...||:.                     ..||.:.
Human  1917 GGKPAMSYASALRAPPK----------PRPPPEQAKK---------------------SSDPLSL 1950

  Fly  2088 IREL----GQATTGFYNYFQ 2103
            .:||    ...:.|||:||:
Human  1951 FQELSLGSSSGSNGFYSYFK 1970

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HelzNP_001261848.1 zf-CCCH 329..353 CDD:279036 14/23 (61%)
TIGR00376 657..1236 CDD:273041 362/583 (62%)
AAA 810..>886 CDD:99707 53/76 (70%)
AAA_12 1003..1213 CDD:289832 155/211 (73%)
HELZXP_006722277.1 zf-CCCH 181..205 CDD:279036 14/23 (61%)
AAA_11 669..861 CDD:289831 124/191 (65%)
P-loop_NTPase 669..>766 CDD:304359 66/96 (69%)
DNA2 <785..1099 CDD:224037 228/314 (73%)
UvrD_C_2 868..1079 CDD:304668 155/211 (73%)
PHA03160 <1656..1815 CDD:165431 24/176 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157106
Domainoid 1 1.000 317 1.000 Domainoid score I1262
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1043 1.000 Inparanoid score I265
Isobase 1 0.950 - 0 Normalized mean entropy S4243
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D286011at2759
OrthoFinder 1 1.000 - - FOG0008398
OrthoInspector 1 1.000 - - oto89615
orthoMCL 1 0.900 - - OOG6_107750
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X6388
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.610

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