Protein Alignment Helz and ECM32

DIOPT Version :10

• Sequence 1: NP_648725.2
• Gene: Helz / 39613
• FlyBaseID: FBgn0036451
• Length: 2103
• Species: Drosophila melanogaster
• Sequence 2: NP_011103.1
• Gene: ECM32 / 856923
• SGDID: S000000978
• Length: 1121
• Species: Saccharomyces cerevisiae
• Alignment Length: 1372
• Identity: 254/1372 - (18%)
• Similarity: 418/1372 - (30%)
• Gaps: 535/1372 - (38%)

  Fly    39 GQSAGSRAQKDQQIACLLGRCECLLELGKFEGCLADAYKVLTLLSEQT-----------ECLAS- 91
            |:.:...|.::.::.|              :.||..:.:....:||::           |...|
Yeast   109 GEESNLNANRNGEVLC--------------DKCLPKSNRAKDFVSEKSGRFLYIYLGLNETQNST 159

  Fly    92 ----------VSRARRWLVHALFKMHKYGDAEIFLSKWINELSGQQ--IYSDISKTLERYKSIIQ 144
                      |.|.::....|..|..|....|..:|:...|:..:.  |.|..|..|..:|..
Yeast   160 RKPRKKGGRRVGRGKKGRKGAKIKKEKKETFEAKISRIAYEVKKENSTIQSSSSSNLRNFKGF-- 222

  Fly   145 MIMNGQHKAQALKIPHARLEDEMAILDTKLDHWATNNLPLDKYSKLLSNKGLKKREQQQQQQQQQ 209
                             :..:...::..|:....|:.          ||.|...|.:.:..:...
Yeast   223 -----------------KAVESDPVVAAKVSKSETSR----------SNPGPSNRNKGKGNKANH 260

  Fly   210 QQQNGNGIG---------------SYASSSSSSSTGSSSTMSSSSTSLHKTNDLLAAMKLTAGKH 259
            ::.:|||||               |........:|.|..|.:|.....:::.|          ||
Yeast   261 KKNSGNGIGKEKERKTNIRNNVRNSQPIPEDRKNTNSHVTTNSGGKGKNESVD----------KH 315

  Fly   260 ---QPG--SGDGSGSDQGDQAAPSTTCSYCTITFQTRNELRQHCQTEAHQKVIMSDEGRDWKWRP 319
               ||.  :|:||||       .:||            .|::..:..|.||.    :|.|.....
Yeast   316 QLPQPKALNGNGSGS-------TNTT------------GLKKGKKDHAGQKT----KGNDKTGNK 357

  Fly   320 PPRGYTLDTYSLCETFSEAHICHYGAQCVEAHGQDELNEWKERFEYRRMRMQKACEKELYGKSYT 384
            .||                          ||                  ::..|..|...||...
Yeast   358 NPR--------------------------EA------------------KLNSAGRKNALGKKSN 378

  Fly   385 EQV---LDRWIQATAPERVMCERVPDMEARCEQQLVTSISSKTSKREWLFQLETKKPLKAVALLQ 446
            .|.   ..||...:..|   ..|.|.:.   ..:..|||:...::.:     :..||     .|.
Yeast   379 NQPNKGTSRWTIGSDTE---SSREPSIS---PNENTTSITKSRNRNK-----KASKP-----TLN 427

  Fly   447 DAHRNHFALKSIKMCKPTESSMELKSDQEWLAGSSSQSETSNEDSATLIHEITVEFHTEIYGTFR 511
            :..      |:..|.|..|:..:.|::     |.:...:...|:...|..          |.||:
Yeast   428 EKS------KTTTMPKKLETKNQEKNN-----GKTKDGKLIYEEGEPLTR----------YNTFK 471

  Fly   512 QAICFDVGQEPLLVRHLCVDVLPVNDAEKIEEIKRDIINSSATRWDVANTQLTRFETTIGTHLKT 576
            ..:.:                                                   ..:.|:|..
Yeast   472 STLSY---------------------------------------------------PDLNTYLND 485

  Fly   577 EAYLSDLEH--ERELLERYPC--PR---AATFTLTQSTIVEKRLTQNNYRSRIHELLSVEEIARY 634
            .::...||.  |.|.::.:..  ||   ...|.:.    |||     |..|.:.:||....:|
Yeast   486 YSFALFLEQKLENEFVQNFNILWPRNEKDTAFIIN----VEK-----NNNSELEKLLPANLLA-- 539

  Fly   635 EQIAR--YNVRTRLTVASN------YILTPAGMATSTAKYSLAGELFALMRLGKDISEDTSPGRL 691
              :.|  :|.|......:.      ||.... ::....||.|..|||:...|.......:|..:|
Yeast   540 --LGRPAFNERQPFFFCTQDEQKVWYIFIKE-LSIQRGKYVLLVELFSWNNLSLPTKNGSSQFKL 601

  Fly   692 ILSNCSSVYISKPEDPDSKADPTKRAVYEALIEDKGKNVIYLKLSAKCVEAMALQADTELEVDIQ 756
            :.::..                |.|.:: |:........|.|.|..|.::            :|.
Yeast   602 LPTSAQ----------------TSRILF-AMTRITNPKFIDLLLGQKPIK------------EIY 637

  Fly   757 FQLNRMPYCEWHNAVDKITDFRLIFPATELEPSIPWTPKKQWADSCEPKLNAKQREAV-----NA 816
            |                  |.||.|.:                    .|||..|:.||     |:
Yeast   638 F------------------DNRLKFSS--------------------DKLNRSQKTAVEHVLNNS 664

  Fly   817 ITTALSIKLPPILLIGPFGTGKTYTLAQAIKQLLTQPEAKILIC-THSNSAADLYIKEYLHPWIE 880
            ||          :|.||.|||||.|:.:.|.|::.:..|..::| ..||.|.|.         |.
Yeast   665 IT----------ILQGPPGTGKTSTIEEIIIQVIERFHAFPILCVAASNIAIDN---------IA 710

  Fly   881 EGLKEATP----LRVYYHKRWSATVNGVVQKYCITDGVGNFLRPTVEDIMRHRIVVVTLSISMEL 941
            |.:.|..|    ||:...|:        .|:|.....:|        :|..|.||...||..|::
Yeast   711 EKIMENRPQIKILRILSKKK--------EQQYSDDHPLG--------EICLHNIVYKNLSPDMQV 759

  Fly   942 ATLGLPKG----------------------------LFTH-----------------IFLDEAAQ 961
            ......:|                            :||.                 :.:|||.|
Yeast   760 VANKTRRGEMISKSEDTKFYKEKNRVTNKVVSQSQIIFTTNIAAGGRELKVIKECPVVIMDEATQ 824

  Fly   962 AMECEAIMPLALANDSTRIVLAGDHMQMSPELFSAFAKERKLHISLLERLYDHYPSNFPCKILLC 1026
            :.|...::||:|.. ....|..||..|:     |:|:...:|..||.||:..:  ..:...::|.
Yeast   825 SSEASTLVPLSLPG-IRNFVFVGDEKQL-----SSFSNIPQLETSLFERVLSN--GTYKNPLMLD 881

  Fly  1027 ENYRAHEAIIRFTSELFYEQKL---VASGKQPRHDRFYPLTFF------TTRGEDVQ-DKNSTAF 1081
            ..||.|..|..|..:..|..:|   |...::......:||.|:      .:|....| |.....:
Yeast   882 TQYRMHPKISEFPIKKIYNGELKDGVTDEQKAWPGVQHPLFFYQCDLGPESRVRSTQRDIVGFTY 946

  Fly  1082 YNNAEVYEVVE--RVSELRKRWPSAWGKLNDTSIGIMTPYSDQVFRIRSELRK------------ 1132
            .|..|..|:|:  ::..|.|:.|.       ..||::||||.|...:...|.|
Yeast   947 ENKHECVEIVKIIQILMLDKKVPL-------EEIGVITPYSAQRDLLSDILTKNVVINPKQISMQ 1004

  Fly  1133 --------------------------RRMGGISVERVLNVQGKQFRAVFLSTVRTRRTCMPQGSA 1171
                                      ..:.|:.|..|.:.||.:...:..|.||
Yeast  1005 QEYDEIELFNAAGSQGTAGSLQNNVINIINGLHVATVDSFQGHEKSFIIFSCVR----------- 1058

  Fly  1172 PGSASTTSIGDADADYGFLSNSKLLNTAITRAQSLVAVVGDPVALCSIGRCRK---VWERFIEIC 1233
                     .:.:...|||.:.:.||.|:|||:..:.|||:...|      ||   :|:.:|...
Yeast  1059 ---------NNTENKIGFLRDKRRLNVALTRAKHGLIVVGNKNVL------RKGDPLWKDYITYL 1108

  Fly  1234 DEHKSLF 1240
            :|.:.:|
Yeast  1109 EEQEVIF 1115

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Helz	NP_648725.2	zf-CCCH	329..353	CDD:459885	2/23 (9%)
		DEXXQc_HELZ	805..1030	CDD:350835	66/279 (24%)
		DNA2	<925..1236	CDD:440729	85/408 (21%)
ECM32	NP_011103.1	TIGR00376	612..1114	CDD:273041	133/628 (21%)
		AAA_12	860..1092	CDD:463780	56/260 (22%)