DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Helz and SDE3

DIOPT Version :9

Sequence 1:	NP_001261848.1	Gene:	Helz / 39613	FlyBaseID:	FBgn0036451	Length:	2103	Species:	Drosophila melanogaster
Sequence 2:	NP_172037.1	Gene:	SDE3 / 837047	AraportID:	AT1G05460	Length:	1002	Species:	Arabidopsis thaliana

Alignment Length:	770	Identity:	211/770 - (27%)
Similarity:	345/770 - (44%)	Gaps:	168/770 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   587 RELLERYPCPRAATFTLTQSTIVEKRLTQNNYRSRIHELLSVEEIARYEQIARYNVRTRLTVASN 651
            ||::|....|          ..:.:.||..||.:....||.:||:...|.:..|::
plant   224 REMIENKEFP----------DDLNEGLTARNYANYYKTLLIMEELQLEEDMRAYDM--------- 269

  Fly   652 YILTPAGMATSTAKYSLAGELFALMRLGKDISEDTSPG----RLILSNCSSVYISKPEDPDSKAD 712
                               |..::.|.|..:|.:. ||    |..|.:...:::....|     |
plant   270 -------------------ENVSMKRRGIYLSLEV-PGLAERRPSLVHGDFIFVRHAYD-----D 309

  Fly   713 PTKRAVYEALIEDKGKNVIYLKLSAKCVEAMALQADTELEV-DIQFQLNRMPYCEWHNAVD--KI 774
            .|..| |:..:.....:.:::|.:::     ..|..|...| :::|..||:.....:.|||  ::
plant   310 GTDHA-YQGFVHRVEADEVHMKFASE-----FHQRHTAGSVYNVRFTYNRINTRRLYQAVDAAEM 368

  Fly   775 TDFRLIFPA-------TELEPSIPWTPKKQWADSCEPKLNAKQREAVNAITTALSIK-LPPILLI 831
            .|...:||:       .:.:|.:|          ..|.|||:|   :.:|...|..| .||.::.
plant   369 LDPNFLFPSLHSGKRMIKTKPFVP----------ISPALNAEQ---ICSIEMVLGCKGAPPYVIH 420

  Fly   832 GPFGTGKTYTLAQAIKQL-LTQPEAKILICTHSNSAADLYIKEYLHPWIEEG--LKEATPLRVYY 893
            ||.|||||.||.:||.|| .||..|::|:|..||||||..:::.|   ..||  :|:....|:..
plant   421 GPPGTGKTMTLVEAIVQLYTTQRNARVLVCAPSNSAADHILEKLL---CLEGVRIKDNEIFRLNA 482

  Fly   894 HKRWSATVNGVVQKYCITDGVGNFLRPTVEDIMRHRIVVVTLSISMELATLGLPKGLFTHIFLDE 958
            ..|....:...:.::|..|.: .|..|.::.:.|:::||.|...:..|...|:.:|.||||.|||
plant   483 ATRSYEEIKPEIIRFCFFDEL-IFKCPPLKALTRYKLVVSTYMSASLLNAEGVNRGHFTHILLDE 546

  Fly   959 AAQAMECEAIMPLA-LANDSTRIVLAGDHMQMSPELFSAFAKERKLHISLLERLY--DHY---PS 1017
            |.||.|.|.::.:: |....|.:|||||..|:.|.::|..|:...|..|.||||:  |:|   ..
plant   547 AGQASEPENMIAVSNLCLTETVVVLAGDPRQLGPVIYSRDAESLGLGKSYLERLFECDYYCEGDE 611

  Fly  1018 NFPCKILLCENYRAHEAIIRFTSELFYEQKLVASGKQ-----------PRHDRFYPLTFFTTRGE 1071
            |:..|  |.:|||.|..|:...|:|||:.:||||.:.           |..:  :|:.|:..:|.
plant   612 NYVTK--LVKNYRCHPEILDLPSKLFYDGELVASKEDTDSVLASLNFLPNKE--FPMVFYGIQGC 672

  Fly  1072 DVQDKNSTAFYNNAEVYEVVERVSELRKRWPSAWGKLNDTSIGIMTPYSDQVFRIRSELRKRRMG 1136
            |.::.|:.:::|..|:.:|:|.:..|     :|...:.:..||::|||..||.:|:..|.:..|.
plant   673 DEREGNNPSWFNRIEISKVIETIKRL-----TANDCVQEEDIGVITPYRQQVMKIKEVLDRLDMT 732

  Fly  1137 GISVERVLNVQGKQFRAVFLSTVRTRRTCMPQGSAPGSASTTSIGDADADY--GFLSNSKLLNTA 1199
            .:.|..|...||::.:.:.:||||               ||....:.|..|  |||||.:..|.|
plant   733 EVKVGSVEQFQGQEKQVIIISTVR---------------STIKHNEFDRAYCLGFLSNPRRFNVA 782

  Fly  1200 ITRAQSLVAVVGDPVALCSIGRCRKVWERFIEICDEHKSLFGLTWSNLRSQLDGVELKRGYVLNP 1264
            ||||.||:.::|:|..:|.    ...|.:.:..|.::.:..|.          |:         |
plant   783 ITRAISLLVIIGNPHIICK----DMNWNKLLWRCVDNNAYQGC----------GL---------P 824

  Fly  1265 LAPEFVPRALQPEAYLREQAALYLNGPQHGHGGHGPPGPPAHFANAAGMLGPGPA 1319
            ...|||     .|.:.:|.::   ||||:         ||....|.:|.|..|.|
plant   825 EQEEFV-----EEPFKQEGSS---NGPQY---------PPEAEWNNSGELNNGGA 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Helz	NP_001261848.1	zf-CCCH	329..353	CDD:279036
		TIGR00376	657..1236	CDD:273041	178/615 (29%)
		AAA	810..>886	CDD:99707	34/79 (43%)
		AAA_12	1003..1213	CDD:289832	72/227 (32%)
SDE3	NP_172037.1	DEXXQc_Helz-like	396..622	CDD:350796	85/234 (36%)
		AAA_12	592..796	CDD:372468	72/227 (32%)
		Ago_hook	830..957	CDD:371044	14/50 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D286011at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10887
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880