Protein Alignment Helz and Mov10l1

DIOPT Version :10

• Sequence 1: NP_648725.2
• Gene: Helz / 39613
• FlyBaseID: FBgn0036451
• Length: 2103
• Species: Drosophila melanogaster
• Sequence 2: XP_006521619.1
• Gene: Mov10l1 / 83456
• MGIID: 1891384
• Length: 1239
• Species: Mus musculus
• Alignment Length: 1158
• Identity: 279/1158 - (24%)
• Similarity: 440/1158 - (37%)
• Gaps: 348/1158 - (30%)

  Fly   323 GY-TLDTY----SLCETFSEAHICHYGAQCVEAHGQDELNEWKERF----EYRRMRMQKACEKEL 378
            || :..||    |:||.|   |.|.  ...|||........|....    ..|..|:.|.|...|
Mouse   133 GYISQTTYFSLESVCEGF---HPCK--GDWVEAEYWIRPGTWSSEAISVKPLRYKRVDKVCISSL 192

  Fly   379 YGKS--YTEQVLDRWIQATAPERVMCERVPDMEARCEQQLVTSISSKTSKREWLFQLETKKPLKA 441
            .|::  ..:.:.........||..:..|         ..:|.::..::|:..::::.....|:|.
Mouse   193 CGRNGVIEDSIFFSLDSLKLPEGYIPRR---------HDIVNAVVVESSQSCYIWRALCMTPVKR 248

  Fly   442 VALLQDAHRNHFA--------------LKSIKMCKPTES-------------SMELKSDQ--EW- 476
            .|.|.:|.:..:.              :.|....|..||             |.||.|.:  .|
Mouse   249 DATLGEAPQEPYGALLLKNKGDIEVTRMTSFGTLKEGESKSIVIWIENKGKVSRELVSCRLANWD 313

  Fly   477 -------------------LAGSSSQSETSN------EDSATLIHEITVEFHTEIY--------- 507
                               .|||..:.|..|      ||....|.|..:...|||.
Mouse   314 KAHQFRFETQGRSKSCPGAAAGSVPEGENVNSLNHHREDKTDEIPESRLANSTEISPDGCACKEE 378

  Fly   508 ------------------------------------GTFRQ--AICFDVGQEPLLVRHLCVDVLP 534
                                                |..::  .:||   .:.|:.|||.|.|
Mouse   379 SREKGNTPEKQEPEPGGLIPPGEKTHIVVTCSAKNPGRCKELLLLCF---SDFLIGRHLEVSV-- 438

  Fly   535 VNDAEKIEEIKRDIINSSATRWDVANTQLTRFETTIGTHLKTEAYLSDLEHEREL---LERYP-- 594
            |:..|.:..::...   |..:...:.|.::...|.:.|..|..:       .|:|   |.:||
Mouse   439 VSSEEALIAVREPF---SWKKPKSSQTLVSAKTTVVVTTQKRNS-------RRQLPSFLPQYPIP 493

  Fly   595 -----CPRAATFTLTQSTIVEKRLTQNNYRSRIHELLSVEEIARYEQIARYNVRTRLTVASN--- 651
                 |.......||...::.:.|..:||:.:...||.:|||....::..||: :|:.:...
Mouse   494 DRLKKCVEQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIHAEIELKEYNM-SRVVLKRKGDL 557

  Fly   652 YILTPAGMATSTAKYSL-AGELFALMR----------LG-------KDISEDTSPGRLILSNCSS 698
            .:|...|:|.|  :.|| ||:...|..          :|       :|::...:||      ...
Mouse   558 LVLEVPGLAES--RPSLYAGDKLILKSQEYNGHVIEYIGYVMEIHEEDVTLKLNPG------FEQ 614

  Fly   699 VYISKPEDPDSKAD-PTKRAVYEALIEDKGKNVIYLKLSAKCVEAMALQA-----------DTEL 751
            :|..:|.|.:...: .|.|..:.||     :.||:|.:.....|.:.||:           ||:.
Mouse   615 MYNFEPMDVEFTYNRTTSRRCHYAL-----EQVIHLGVKVLFPEEIILQSPQVTGNWSLAQDTKN 674

  Fly   752 EVDIQFQLNRMPYCEWHNAVDKIT--DFRLIF-------------------PATEL----EPSI- 790
            :......:.|..    ..::.|:|  |.:.|.                   |.|::    ..||
Mouse   675 DGQSITNITRND----GQSMTKVTRNDSQSITNIIRNDGQSITNVTRNDGQPITKVTRNNSQSIT 735

  Fly   791 --------PWT----------------------------------------PKKQWADSCEPKLN 807
                    |.|                                        ||.:..:...|.||
Mouse   736 NITRNDGQPITKNKKTVKDQTKHTTEERHVGTTDQPEKASSTAETMDEIQIPKARDKEFFNPVLN 800

  Fly   808 AKQREAVNAITTALSIKLPPILLIGPFGTGKTYTLAQAIKQL-LTQPEAKILICTHSNSAADLYI 871
            ..|:.||..|.:. ..:..|.:|.||.|||||.|:.:|:.|: ...|:::||:|..|||||||..
Mouse   801 ENQKLAVRRILSG-DCRPLPYILFGPPGTGKTVTIIEAVLQVHYALPDSRILVCAPSNSAADLVC 864

  Fly   872 KEYLHPWIEEGLKEATPLRVYYHKRWSATVNGVVQKYCITDGVGNFLRPTVEDI---MRHRIVVV 933
            .. ||.  .:.||.|..:||....|:..|:...::.|| .||         |||   .|.||::.
Mouse   865 LR-LHE--SKVLKPAAMVRVNATCRFEETIIDAIKPYC-RDG---------EDIWRASRFRIIIT 916

  Fly   934 TLSISMELATLGLPKGLFTHIFLDEAAQAMECEAIMPLALAND-STRIVLAGDHMQMSPELFSAF 997
            |.|.:.....:|:..|.|||:|:|||.||.|.|.::||.|.:| :.:||||||.||:.|.:.|..
Mouse   917 TCSSAGLFYQIGVRVGYFTHVFVDEAGQASEPECLIPLGLISDINGQIVLAGDPMQLGPVIKSRL 981

  Fly   998 AKERKLHISLLERL-----YDHYPSNF-------PCKIL-LCENYRAHEAIIRFTSELFY----- 1044
            |....|::|:||||     |....:.|       |..:. |.:|||:|.|::...|.|||
Mouse   982 AMAYGLNVSMLERLMSRPAYLRDENAFGACGAYNPLLVTKLVKNYRSHSALLALPSRLFYHRELE 1046

  Fly  1045 ---EQKLVAS----GKQPRHDRFYPLTFFTTRGEDVQDKNSTAFYNNAEVYEVVERVSELRKRWP 1102
               :.|:|.|    .|.||  :.:||.|...||.:.::..|.::::.||..:|:.....|.:
Mouse  1047 VCADPKVVTSLLGWEKLPR--KGFPLIFHGVRGNEAREGRSPSWFSPAEAVQVMRYCCLLAR--- 1106

  Fly  1103 SAWGKLNDTSIGIMTPYSDQVFRIRSELRKRRMGGISVERVLNVQGKQFRAVFLSTVRTRRTCMP 1167
            |...:::...||::|||..||.:|:..||...:..|.|..|...||:::..:.:||||:..
Mouse  1107 SVSSQVSSKDIGVITPYRKQVEKIKILLRNVDLTDIKVGSVEEFQGQEYLVIVISTVRSNE---- 1167

  Fly  1168 QGSAPGSASTTSIGDADAD----YGFLSNSKLLNTAITRAQSLVAVVGDPVAL 1216
                          |...|    .|||||||..|.||||.::|:.::|:|..|
Mouse  1168 --------------DRFEDDRYFLGFLSNSKRFNVAITRPKALLIILGNPHVL 1206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Helz	NP_648725.2	zf-CCCH	329..353	CDD:459885	10/27 (37%)
		DEXXQc_HELZ	805..1030	CDD:350835	89/242 (37%)
		DNA2	<925..1236	CDD:440729	107/325 (33%)
Mov10l1	XP_006521619.1	DEXXQc_Mov10L1	798..1027	CDD:350836	89/242 (37%)
		SF1_C_Upf1	1028..1218	CDD:350195	60/202 (30%)