DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Helz and mov10l1

DIOPT Version :9

Sequence 1:	NP_001261848.1	Gene:	Helz / 39613	FlyBaseID:	FBgn0036451	Length:	2103	Species:	Drosophila melanogaster
Sequence 2:	NP_001072624.1	Gene:	mov10l1 / 780080	XenbaseID:	XB-GENE-1217451	Length:	1244	Species:	Xenopus tropicalis

Alignment Length:	990	Identity:	245/990 - (24%)
Similarity:	396/990 - (40%)	Gaps:	280/990 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 CEKELYGKSYTEQVLDRWIQATAPERVMCERVPDMEAR-CEQQLVTSISSKTSKREWLFQLETK- 436
            |||:   |:...|        |||..|:...  ::.|: |  ||...:||.|..   ||...||
Frog   353 CEKD---KADLHQ--------TAPFSVLTNN--ELTAKFC--QLGYKVSSATPS---LFNNCTKF 399

  Fly   437 -----KPLKAVALLQDAHRNHFALKSIKMC-KPTESSMELKSDQEWLAGSSSQSETSNEDS---- 491
                 .||.:           .....::.| :|::..||    |..|..:..:.::.|.||
Frog   400 VRGSTDPLSS-----------GLYGPLRHCPEPSDDPME----QPVLGATIHEEQSCNMDSNVNS 449

  Fly   492 ----ATLIHE-----------------ITVEFHTEIYGTFRQ--AICFD---VGQEPLLVRHLCV 530
                :.|.|.                 |.|.......|..::  .:||.   :|:        |:
Frog   450 GVTDSVLQHSSNAPTSEVVILPGEKTFIIVTCEARNPGRCKELLLLCFSDFMIGR--------CL 506

  Fly   531 D-----------VLPVNDAEKIEEIKRDIINSSATRWDVANTQLTRFETTIGTHLKTEAYLSDLE 584
            :           :.||..|.|.:::.::.:::|.|.....:.:::|
Frog   507 EGTVESEEESFLLPPVEFASKQKKVPQEYMSNSRTVLSAPHKRISR------------------- 552

  Fly   585 HEREL---LERYPCP---RAAT----FTLTQSTIVEKRLTQNNYRSRIHELLSVEEIARYEQIAR 639
              |:|   |..||.|   |..|    ..|.....:.:.||.:|||.|:..||.:|:|....:|..
Frog   553 --RQLPSFLPLYPIPDRLRKCTEQKMDILALEPCLGEVLTLSNYRKRMSTLLWLEDIHAEMEIQE 615

  Fly   640 YNVRTRLTVASNYILTPAGMATSTAKYSLAGELFALMRLGKDISEDTSPGRLILSNCSSVYISKP 704
            :::       |...|...|.             |.|:.: ..|:|    ||..|:....|::...
Frog   616 FSL-------SGVCLQKRGG-------------FLLLEV-PGIAE----GRPFLNQGDKVFLKYQ 655

  Fly   705 EDPDSKADPTKRAV-YEALIEDKGKNVIYLKLSAKCVEAMALQADTELE-------VDIQFQLNR 761
            |       .|..|: :..||.:..:            |.:.|:.:.|||       :|::|.:||
Frog   656 E-------LTTTAIQFVGLIVEIHE------------EEITLRVNEELEQSYKFEPMDVEFVVNR 701

  Fly   762 MPYCEWHNAVDKITDF--RLIFPAT----------------------------ELEPSIP----- 791
            :.......||::....  :::||.|                            |...|.|
Frog   702 VTSRRCQFAVEQAEHLGQKVLFPDTVELQSPQVASRDTSEIDCPEKKEKTGYQETNQSNPTSRGK 766

  Fly   792 --------------------WTPKKQWADSCEPKLNAKQREAVNAITTALSIKLPPILLIGPFGT 836
                                .:|.|:........||..|:.||..|... ..:..|.:|.||.||
Frog   767 NAVYMSDMVTVATQTSTKGSGSPVKKKGQFFNNLLNNHQKLAVKRILGG-ECRPTPYILFGPPGT 830

  Fly   837 GKTYTLAQAIKQL-LTQPEAKILICTHSNSAADLYIKEYLHPWIEEGLKEATPLRVYYHKRWSAT 900
            |||.|:.:||.|: ...|:::||:|..|||||||.... ||.  ...|:..:.:||....|...|
Frog   831 GKTVTIIEAILQIYYALPDSRILVCAPSNSAADLVCLR-LHQ--SNQLEPGSMVRVNATCRLEET 892

  Fly   901 VNGVVQKYCITDGVGNFLRPTVEDIMRHRIVVVTLSISMELATLGLPKGLFTHIFLDEAAQAMEC 965
            |...|:.||   |.|..:|..    .|.||::.|.|.:.....:||..|.|||:|:|||.||.|.
Frog   893 VCDAVRPYC---GPGEDIRKA----SRFRIIISTCSSAGMFYQIGLRVGHFTHVFVDEAGQASEP 950

  Fly   966 EAIMPLALANDST-RIVLAGDHMQMSPELFSAFAKERKLHISLLERL------------YDHYPS 1017
            |.::||.|.::.| :|:||||.||:.|.:.|..:....|::|.||||            |....:
Frog   951 ECLIPLGLISEVTGQIILAGDPMQLGPIIKSRVSLAYGLNVSFLERLMARPLYLRDEESYGACGN 1015

  Fly  1018 NFPCKIL-LCENYRAHEAIIRFTSELFYEQKL------VASGKQPRHDRF----YPLTFFTTRGE 1071
            ..|..|. |.:|||:|.|::...|:|||.::|      ....|..|.|:.    :||.|...||.
Frog  1016 YNPLLITKLMKNYRSHAALLHLPSKLFYHKELEVCADPAVVNKLLRWDKLPHKGFPLIFHGVRGT 1080

  Fly  1072 DVQDKNSTAFYNNAEVYEVVERVSELRKRWPSAWGKLNDTSIGIMTPYSDQVFRIRSELRKRRMG 1136
            ::::.::.:::|.:|..:.:.....|.|...::   ::...||::|||..||.:||:.||...:.
Frog  1081 EMREGSNPSWFNPSEAVQAMRYCCVLAKHVTTS---VSAKDIGVITPYRKQVEKIRTLLRTADLS 1142

  Fly  1137 GISVERVLNVQGKQFRAVFLSTVRTRRTCMPQGSAPGSASTTSIGDADADYGFLSNSKLLNTAIT 1201
            .|.|..|...||::|..:.:|.||:....:.:             |:....|||.:.|..|.|||
Frog  1143 DIKVGSVEEFQGQEFLVIIISMVRSCEDSLHE-------------DSRHLLGFLCSPKRFNVAIT 1194

  Fly  1202 RAQSLVAVVGDPVAL 1216
            |.::|:.|:|:|..|
Frog  1195 RPKALLIVLGNPHVL 1209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Helz	NP_001261848.1	zf-CCCH	329..353	CDD:279036
		TIGR00376	657..1236	CDD:273041	176/648 (27%)
		AAA	810..>886	CDD:99707	31/76 (41%)
		AAA_12	1003..1213	CDD:289832	65/232 (28%)
mov10l1	NP_001072624.1	S1-like	36..>73	CDD:291136
		S1-like	182..234	CDD:291136
		AAA_11	801..982	CDD:289831	75/191 (39%)
		P-loop_NTPase	801..>978	CDD:304359	74/187 (40%)
		DNA2	<914..1213	CDD:224037	98/312 (31%)
		AAA_12	989..1206	CDD:289832	65/232 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020