DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Helz and zgc:154086

DIOPT Version :9

Sequence 1:	NP_001261848.1	Gene:	Helz / 39613	FlyBaseID:	FBgn0036451	Length:	2103	Species:	Drosophila melanogaster
Sequence 2:	NP_001070795.1	Gene:	zgc:154086 / 768184	ZFINID:	ZDB-GENE-061013-333	Length:	1106	Species:	Danio rerio

Alignment Length:	963	Identity:	229/963 - (23%)
Similarity:	385/963 - (39%)	Gaps:	248/963 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 TEQVLDRWIQATAPERVMCERVPDMEARCEQQLVTSISSKTSKREWLFQ----LETKKPLKAVAL 444
            :.|.|..|       |.:|.......|:|.:|     ....:..:.|.|    |:..:..::|.|
Zfish   231 SSQSLYSW-------RALCMTPLQRSAQCSEQ-----KEPDADLQALLQEKGGLQVSQQNQSVCL 283

  Fly   445 L------------------QDAHR---------NHFALKSIKMC----------KPTESSMELKS 472
            |                  |...|         ..|:::|:..|          :..|..:::..
Zfish   284 LMGDCSELLIWVQNCGSERQQLQRCVCAGWDSAQQFSVRSVSRCEDGGTEAPPVRMLEEPLDIHP 348

  Fly   473 DQEWLAGSSSQSETSNEDSATLIHEITVEFHTEIYGTFRQAICFDVGQEPLLVRHL--CVDVLPV 535
            .|:........::|....|..|:    :.|.:...|. |..:.....:|.||...:  |....|.
Zfish   349 GQKMCVCVCCTAKTLGRSSELLL----LHFSSFTIGR-RLELSVSSVEEQLLNPSMPYCSPSAPA 408

  Fly   536 NDAEKIEEIKRDIINSSATRWDVANTQLTRFETTIGTHLKTEAYLSDLEHERELLERYPCPRAAT 600
            ...:.::.:   .:::..|...:....|..|   :|.:...:|....:|.::::|
Zfish   409 QLPQPLQVL---TVSAPPTPLRLTRRHLPNF---LGNYGVPQALRECVEAQKDVL---------- 457

  Fly   601 FTLTQSTIVEKRLTQNNYRSRIHELLSVEEIARYEQIARYNVRTRLTVASNYILTPAGMATSTAK 665
              :.|..:.| .|:......|...||.:||:....:|                          .:
Zfish   458 --VVQPALAE-ALSLRTMLPRFSALLWLEELQAEREI--------------------------RE 493

  Fly   666 YSLAGELFALMRLGKDISEDTSPGRLILSNCSSVYISKP---EDPDSKADPTKRAVYEALIEDKG 727
            :||.|   |::|.|........||  :.....|::|...   :.|.|.....:...|...|.|
Zfish   494 FSLTG---AILRRGAVYLHLEVPG--LAEGRPSLFIGDKVVLKKPCSGGVVIEYIAYVTEISD-- 551

  Fly   728 KNVIYLKLSAKCVEAMALQADTELE-------VDIQFQLNRMPYCEWHNAVDKITDF--RLIFPA 783
                         |.::|:.:.|.:       :|::|..||:.....|.|:::...|  .::||:
Zfish   552 -------------EDVSLRVNAEFQSSYLGEPLDVEFSFNRLTMRRCHCALEQSKHFGENILFPS 603

  Fly   784 TELEPSIP-----WTPKKQWADSCE---------------------------------------- 803
            . |:...|     |.|:::..:..:
Zfish   604 M-LQLQAPQWSGEWGPQEEQDEELKDGEQTQTVTGSALTAEMVSVATQTKTDLSVTEKRIPNPGQ 667

  Fly   804 ---PKLNAKQREAVNAITTALSIKLPPILLIGPFGTGKTYTLAQAIKQLLTQPE-AKILICTHSN 864
               |.|||.|::||..|.:..| :..|.:|.||.|||||.||.:||.|:..:.. :::|:||.||
Zfish   668 FFNPDLNAAQKQAVRRILSGES-RPTPYVLFGPPGTGKTITLIEAILQVHHRISCSRVLVCTPSN 731

  Fly   865 SAADLYIKEYLHPWIEEGLKEATPLRVYYHKRWSATVNGVVQ-KYCITDGVGNFLRPTVEDIMR- 927
            |||||......|..             :.|....|.||...: :..:::.:..:.| ..|||..
Zfish   732 SAADLICMRLHHSG-------------FLHSASLARVNATCRPEESMSEELRQYAR-AGEDIRHA 782

  Fly   928 --HRIVVVTLSISMELATLGLPKGLFTHIFLDEAAQAMECEAIMPLALAND-STRIVLAGDHMQM 989
              |||||.|.|.:.....:||..|.|||:|:|||.||.|.|.::||:|.:: |.:||||||..|:
Zfish   783 SFHRIVVSTCSSAGMFYQIGLRVGHFTHVFVDEAGQATEPETLIPLSLLSETSGQIVLAGDPKQL 847

  Fly   990 SPELFSAFAKERKLHISLLERLYDHYPSNFPC-----------KILLCENYRAHEAIIRFTSELF 1043
            .|.:.|..|....|.:||||||..:  |.:.|           |:|.  |||:|||::...|.||
Zfish   848 GPVVKSRLASVFGLGVSLLERLMGN--SLYACGERGFNPLLVTKLLY--NYRSHEALLDLPSRLF 908

  Fly  1044 YEQKLVASGKQPRHD----------RFYPLTFFTTRGEDVQDKNSTAFYNNAEVYEVVERVSELR 1098
            |..:|....::...|          |.:||.|...||.::::..:.:::|.||..:|:....:|.
Zfish   909 YAGELCVRAQRAAVDSLCHWNKLPTRGFPLIFHGVRGSEMREGCNPSWFNPAEAVQVMMYCCQLA 973

  Fly  1099 KRWPSAWGKLNDTSIGIMTPYSDQVFRIRSELRKRRMGGISVERVLNVQGKQFRAVFLSTVRTRR 1163
            ||   .:..::...||::.||..||.:||..|::..:|.:.|..|...||::|..:.|||||:..
Zfish   974 KR---LYNPISAADIGVIAPYRKQVEKIRVLLQRVGLGEVKVGSVEEFQGQEFLIMILSTVRSNE 1035

  Fly  1164 TCMPQGSAPGSASTTSIGDADADYGFLSNSKLLNTAITRAQSLVAVVGDPVAL 1216
            :.:.:             :.....|||||.|..|.|||||::|:.|:|:|..|
Zfish  1036 SLLNE-------------ELQCMLGFLSNPKRFNVAITRAKALLIVIGNPHVL 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Helz	NP_001261848.1	zf-CCCH	329..353	CDD:279036
		TIGR00376	657..1236	CDD:273041	181/647 (28%)
		AAA	810..>886	CDD:99707	30/76 (39%)
		AAA_12	1003..1213	CDD:289832	71/230 (31%)
zgc:154086	NP_001070795.1	S1-like	45..97	CDD:291136
		AAA_11	672..854	CDD:289831	74/196 (38%)
		P-loop_NTPase	673..>850	CDD:304359	73/191 (38%)
		AAA_12	861..1072	CDD:289832	71/230 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010