DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Helz and helz2b

DIOPT Version :9

Sequence 1:	NP_001261848.1	Gene:	Helz / 39613	FlyBaseID:	FBgn0036451	Length:	2103	Species:	Drosophila melanogaster
Sequence 2:	XP_699251.2	Gene:	helz2b / 570654	ZFINID:	ZDB-GENE-070912-617	Length:	2781	Species:	Danio rerio

Alignment Length:	1033	Identity:	321/1033 - (31%)
Similarity:	488/1033 - (47%)	Gaps:	178/1033 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 FQTRNELRQHCQ--TEAHQKV----------------IMSDEGRDWKW-----RPP-PRGYTLDT 328
            |....|||..|.  ||.|..:                :...:.|..:|     ||. ||.   ..
Zfish    14 FMQMYELRAVCNGCTEKHSHISYTIIATPHRCSHDVLLARAKVRGSRWSRVFQRPTHPRP---QR 75

  Fly   329 YSLCETFSEAHICH-YGAQCVEAHGQDELNEWK----ERFEYRRM------RMQKACEK------ 376
            |.:|..|.|...|. :..:|..|...:|...|.    ...::|.:      |.::|..|
Zfish    76 YEVCWYFQEDVGCRIHRDRCTFASSPEEAAVWNLQKHTNLDHRTIIHLITQRKRRAESKKEAQPS 140

  Fly   377 --ELYGKSYTEQVLDRWIQATAPERVMCERVPDMEARCEQQLVTSISSKTSKREWLFQLETKKPL 439
              ||  .||.|::|:.:..::....|:.|.|.|:....::.|......:.::..|.|.:.|::.|
Zfish   141 FQEL--SSYQEKLLEEYRSSSNEILVISEHVDDVRVTHDENLSMDCLQEDNEIRWKFTITTERSL 203

  Fly   440 KAVALLQDAHRNHFALK-SIKMCKPTESSM---ELKSDQEWLAGSSSQSETSNEDSATLIHEITV 500
            ..||||:..:...|:|. |::...|..:.:   ||:|.|.                   .::::|
Zfish   204 AHVALLKVENGAVFSLSDSLRNTIPPITHIAGHELRSSQS-------------------TYQLSV 249

  Fly   501 EFHTEIYGTFRQAICFDVGQEPLLVRHLCVDV---LPVNDAEKIEEIKRDIINSSATRWDVANTQ 562
            .|.:...|.:.|.:.||....|:|:|.|.|.|   ..|...|..|....:|:::.  ||:..|..
Zfish   250 SFLSFHPGVYEQWLVFDFDMRPVLLRKLKVRVGQQFLVQPEEAEESECAEILSNE--RWNRGNRV 312

  Fly   563 LTRFETTIGTHLKTEAYLSDLEHERELLERYPCPRA-------ATFTLTQSTIVEKRLTQNNYRS 620
            :..|             .:..|.:.:||.:|..|:.       |..:|.        |.:.|||.
Zfish   313 IVPF-------------FARKEEDEQLLSKYKPPQLNLQFNPHADHSLP--------LHRENYRE 356

  Fly   621 RIHELLSVEEIARYEQIARYNVRTRLTVASNYILTPAGMATSTAKYSLAGELFALMRLGKDISED 685
            |.|..|..||||..|.|:|.||...::: ||::.....:.     |:..|:|||.:::...::.|
Zfish   357 RAHHFLFREEIAEEELISRLNVCGTVSL-SNHLSDAMSLF-----YAAPGKLFANLKVSCSLTPD 415

  Fly   686 TSPG-------RLILSNCSSVYISKPEDPDSKADPTKRAVYEALI--EDKGKNVIYLKLSAKCVE 741
            :..|       ::.|.||.|...|...:       .:..||||.:  |..|:..:.|:||.:||.
Zfish   416 SPEGVVLKRGVQMALVNCKSTKASMSAE-------HRNHVYEAFVMKETVGEGHLSLELSTQCVS 473

  Fly   742 AMALQADTELEVDIQFQLNRMPYCEWHNAVDKITDFRLIFPATELEPSIPWTPKKQWADSCEP-- 804
            .:.|:.:|..|:::||||||:.:|:.|.|:|::.|...:.|              .:::.|.|
Zfish   474 ELELRKETTCEMEVQFQLNRLSFCQIHQAIDRLPDLHNVLP--------------DFSNCCVPVN 524

  Fly   805 -----KLNAKQREAVNAITTALSIK--LPPILLIGPFGTGKTYTLAQAIKQLLTQPEAKILICTH 862
                 :||.||:.|:|.|.......  ..|:|:.||||||||..||.|.|:|..:.:.|:||||:
Zfish   525 LTKQSQLNNKQQIALNFILGKCEDDKVAAPLLIYGPFGTGKTLCLASAAKELAHRSQNKVLICTY 589

  Fly   863 SNSAADLYIKEYLHPWIEEGLKEATPLRVYYHKRWSATV--NGVVQKYCITDGVG-NFLRPTVED 924
            :||:||||::|:.||:|..|......||:..:|..||.:  :.:.:|||:....| :|:.|...|
Zfish   590 TNSSADLYVREHFHPYIINGHPTLKLLRIKANKGGSAIIATDDITRKYCLCSRDGQSFILPARSD 654

  Fly   925 IMRHRIVVVTLSISMELATLGLPKGLFTHIFLDEAAQAMECEAIMPLALANDSTRIVLAGDHMQM 989
            :..|||::.|.||:..|..|.||||.||||.:|||:|.:|.||:|.|.||:..||:|||||||||
Zfish   655 LESHRIIITTTSIARHLHELKLPKGFFTHILIDEASQMLEGEALMALGLADKHTRVVLAGDHMQM 719

  Fly   990 SPELFSAFAKERKLHISLLERLYDHYPSNF-----PCKILLCENYRAHEAIIRFTSELFY-EQKL 1048
            :|:|||....:|..| :||.||:.:|....     ..:|:..||||:...|:.|.|..|| ...:
Zfish   720 APKLFSVTDDKRSEH-TLLNRLFHYYQDQSINIAKKSRIIFNENYRSTTEIVDFVSTYFYVSDGI 783

  Fly  1049 VASGKQPRHDRFYPLTFFTTRGEDVQDK--NSTAFYNNAEVYEVVERVSELRKRWPSAWGKLNDT 1111
            .|.|....|.|..||.|...|||.....  .||::.|.|||..||..|..|...||..||..:..
Zfish   784 KARGDVHPHPRLKPLIFHHVRGECHLSSTITSTSWLNYAEVNSVVNMVQVLLTDWPMEWGDKDPK 848

  Fly  1112 SIGIMTPYSDQVFRIRSELRKRRMGGISVERVLNVQGKQFRAVFLSTVRTR-RTCMPQGSAPGSA 1175
            .|.:::. ..||..||..||::...|:||:.:.|:||||||.:.::||.|| :......|.|
Zfish   849 QICVLSE-GQQVAAIRIHLRRKGFYGVSVQNLANIQGKQFRVIIITTVHTRDKLLQLDSSCP--- 909

  Fly  1176 STTSIGDADADYGFLSNSKLLNTAITRAQSLVAVVGDPVALCSIGRCRKVWERFIEIC 1233
                        .|..:.:.||||:|||||||.|:||..|||..|:|.|||..:||.|
Zfish   910 ------------EFFDDIRALNTALTRAQSLVVVIGDAGALCCFGKCSKVWRAYIEHC 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Helz	NP_001261848.1	zf-CCCH	329..353	CDD:279036	7/24 (29%)
		TIGR00376	657..1236	CDD:273041	222/607 (37%)
		AAA	810..>886	CDD:99707	35/77 (45%)
		AAA_12	1003..1213	CDD:289832	77/218 (35%)
helz2b	XP_699251.2	AAA_11	530..725	CDD:289831	90/194 (46%)
		AAA	553..688	CDD:99707	59/134 (44%)
		DNA2	<647..959	CDD:224037	135/326 (41%)
		P-loop_NTPase	<662..>721	CDD:304359	35/58 (60%)
		UvrD_C_2	735..935	CDD:304668	76/215 (35%)
		RNB	1255..1482	CDD:279157
		RNB	1544..1845	CDD:214935
		AAA_11	2289..2532	CDD:289831
		AAA_19	2297..>2368	CDD:289986
		AAA_12	2543..2746	CDD:289832
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910