Protein Alignment Helz and mov10a

DIOPT Version :10

• Sequence 1: NP_648725.2
• Gene: Helz / 39613
• FlyBaseID: FBgn0036451
• Length: 2103
• Species: Drosophila melanogaster
• Sequence 2: XP_002662576.2
• Gene: mov10a / 566858
• ZFINID: ZDB-GENE-091230-8
• Length: 1001
• Species: Danio rerio
• Alignment Length: 1138
• Identity: 285/1138 - (25%)
• Similarity: 430/1138 - (37%)
• Gaps: 367/1138 - (32%)

  Fly   291 RNELRQHCQTE---------AHQKVI---------MSDEGR-DWKWRPPPRGYTLDTYSLCETFS 336
            |||||.....|         :..|||         .|..|: .::|:|..|.|..|
Zfish    27 RNELRDIYNLEFKRDGSEEPSFAKVIRALSCFKKARSSHGKIFFQWKPKMRVYYCD--------- 82

  Fly   337 EAHICHYGAQCVEAHGQDELNEWKERFEYRRMRMQKACEKELYGKSYTEQVLDRWIQATAPERVM 401
                                 :|                     ||:.:       |.|:|.
Zfish    83 ---------------------QW---------------------KSFVQ-------QNTSPS--- 95

  Fly   402 CERVPDMEARCEQQLVTSISSKTSKREWLFQLETKKPLKAVALLQDAHRNHFALKSIKMCKPTES 466
               .||.:.          :|.:|.|.....:.|.|...|..:|     |....|..::.| .:.
Zfish    96 ---APDSDP----------ASSSSPRPTFKPILTPKKKLATEIL-----NKLRSKRAELIK-DKG 141

  Fly   467 SMELKSDQEWLAGSSSQSETSNEDSATLIHEI----TVEFHTE------IYGTFRQAI----CFD 517
            .:|:.||.:...|:.|.:          |.|:    .|:||..      ||.|:..|:    ||.
Zfish   142 GIEISSDPKATKGNVSFT----------IEELGKLFVVKFHIVNQSEGCIYFTYYTALHKMRCFT 196

  Fly   518 VGQE-------PLL--------------VRH-----------LCVDVLPVNDAEK---IEEIKRD 547
            :..:       |||              |.|           .|.:|.|...|:.   :.|::
Zfish   197 LVDKRRVNRVSPLLLCPGEDYDVEVHYNVNHPGHFPATMYFEFCPEVDPPGTAKPFCIVRELE-- 259

  Fly   548 IINSSATRWDVANT----------QLTRF-------------ETTIGTHLKT---------EAYL 580
                :..|..:|.|          |..|.             |::|...||.         .|||
Zfish   260 ----AVVRTGLAETLGPESPYNPKQNRRLRPKSKVVEEGVPPESSITHDLKNMMKMNQYRYPAYL 320

  Fly   581 SDL-EHERELLERYPC------PRAATFTLTQSTIVEKRLTQNNYRSRIHELLSVEEIARYEQIA 638
            .:| :::.|..|..|.      ||.       ..:::.:|...||..|.|.||.:|||.
Zfish   321 KELAKYKLEDSEHLPASLKQHLPRV-------RRLLDTQLCMKNYSERFHLLLHLEEIQ------ 372

  Fly   639 RYNVRTRLTVASNYILTPAGMATSTAKYSLAGELFALMRLGKDISEDTSPGRLILSNCSSVYISK 703
                                |.....||.|.|:...|.:..|.:.....||  :..|..||....
Zfish   373 --------------------MEVDIKKYDLYGKTMTLDKTNKKLLILKVPG--VAENRPSVLRGD 415

  Fly   704 PED---PDSKADPTKRAVYEALIEDKGKNVIYLKLSAKCVEAMALQADTELEVDIQFQLNRMPYC 765
            ..:   .|.:..|.  .|||..:.....:.:.|..|.|.::...    ..::.|::|.:||.|..
Zfish   416 KLNVCLSDDRNQPI--TVYEGYVHRVELDKVILGFSRKLLQKFV----NNMKFDVEFNINRFPLR 474

  Fly   766 EWHNAVDKITDFRL---IFPATELEPSIPWTPKKQWADSCEPKL---------NAKQREAVNAIT 818
            ..|.||:......|   :||:           .|....|..|.|         |.:|:.||..|.
Zfish   475 LQHRAVELAVQHALGNVLFPS-----------DKDTGHSELPHLSMFNKDLENNPEQKAAVQHIL 528

  Fly   819 TALSIKLPPILLIGPFGTGKTYTLAQAIKQL-LTQPEAKILICTHSNSAADLYIKEYLHPWIEEG 882
            :. |.:..|.|:.||.|||||.|:.:||||: .::.::.||.|..||||.||..:..|      |
Zfish   529 SG-SSRPAPYLIFGPPGTGKTVTVVEAIKQVDKSKAQSHILACAPSNSACDLLCERLL------G 586

  Fly   883 LKEA---------------TPLRVYYHKRWSATVNGVVQKYCITDGVGNFLRPTVEDIMRHRIVV 932
            ..:|               .|.::..|..|:             :...:||.|:.|.::.:.|:|
Zfish   587 HVDAHRIYRLCAPSRDPRTVPQKLLKHSNWN-------------EAQDSFLLPSKETLIGYSIIV 638

  Fly   933 VTLSISMELATLGLPKGLFTHIFLDEAAQAMECEAIMPLALANDSTR--IVLAGDHMQMSPELFS 995
            |||..:..|.:.|:..|.|||||:|||.||:|.|.|:.:|...|..:  :|||||..|:.|.|.|
Zfish   639 VTLVTAGRLVSGGVAMGHFTHIFIDEAGQAVEPECIIGIAGLLDPLKGQLVLAGDPQQLGPVLRS 703

  Fly   996 AFAKERKLHISLLERLY-------------DHYPSNFPCKILLCENYRAHEAIIRFTSELFYEQK 1047
            ..|:...|..||||||.             ..|.|.|..|:|  .|||:|.||::..:|||||.:
Zfish   704 PLAQLHGLGQSLLERLMKRNALYQKSQDDNSKYDSRFVTKLL--RNYRSHPAILKIPNELFYENE 766

  Fly  1048 LVASGKQPRHDRF----------YPLTFFTTRGEDVQDKNSTAFYNNAEVYEVVERVSEL----- 1097
            |.....|...:.|          :|:.|....|:|.::.||.:|:|..|:..:|..::.|
Zfish   767 LQVFANQMEREAFCQWEHLPRKGFPVVFHGVMGKDEREANSPSFFNVTEIEVIVNYLNNLMQTQG 831

  Fly  1098 RKRWPSAWGKLNDTSIGIMTPYSDQVFRIR------SELRKRRMGGISVERVLNVQGKQFRAVFL 1156
            :|..|    ||....|||:.||..||.:||      .||:|.:  .|.|..|...||::.:.:.:
Zfish   832 KKGLP----KLGPNDIGIIAPYRKQVEKIRKALNTVGELKKWK--DIKVGSVEEFQGQERKVIIV 890

  Fly  1157 STVRTRRTCMPQGSAPGSASTTSIGDADADYGFLSNSKLLNTAITRAQSLVAVVGDPVALCSIGR 1221
            ||||:            |.:...: |.|.:.|||||.|..|.|:|||:.|:.|||:||.|..
Zfish   891 STVRS------------SVNYVKM-DQDFNIGFLSNEKRFNVAMTRAKGLLIVVGNPVILSK--- 939

  Fly  1222 CRKVWERFIEICDEHKSLFGLTWSNLRSQLDGV 1254
             ...|::||:.|::.:...|..:.:...:.|.|
Zfish   940 -DPTWQKFIQYCEQEQGYTGFDYKDAEGEEDVV 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Helz	NP_648725.2	zf-CCCH	329..353	CDD:459885	0/23 (0%)
		DEXXQc_HELZ	805..1030	CDD:350835	86/264 (33%)
		DNA2	<925..1236	CDD:440729	120/346 (35%)
mov10a	XP_002662576.2	DEXXQc_Helz-like	517..749	CDD:350796	85/253 (34%)
		SF1_C_Upf1	750..951	CDD:350195	71/223 (32%)