DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Helz and helz2a

DIOPT Version :9

Sequence 1:NP_001261848.1 Gene:Helz / 39613 FlyBaseID:FBgn0036451 Length:2103 Species:Drosophila melanogaster
Sequence 2:XP_003198895.2 Gene:helz2a / 562461 ZFINID:ZDB-GENE-120920-1 Length:2656 Species:Danio rerio


Alignment Length:1080 Identity:328/1080 - (30%)
Similarity:514/1080 - (47%) Gaps:151/1080 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 YASSSSSSSTGSSSTMSSSSTSLHKTNDLLAAMK---------LTAGKHQPGSGDGSGSDQGDQA 275
            |......:..|::...:|||    :..||...||         :.|.|.             :|.
Zfish    81 YTKDRGCTRHGNNCQFASSS----EEADLWNVMKDEKLTIPQIVNAIKQ-------------NQR 128

  Fly   276 APSTT---------CSYCTITFQTRNELRQHCQTEAHQKVIMSDEGRDWKWRPPPRGYTLDTYSL 331
            .|..|         |:.|.:.|.|..:...||.|..|::.|..|..:.||.|.||.  |.....|
Zfish   129 TPQITFQEKRGPHDCTLCQVHFPTDEDFMNHCFTVKHRRRIFEDGNKTWKHREPPP--THKDLKL 191

  Fly   332 CETFSEAHICHYGAQCVEAHGQDELNEWKERFEYRRMRMQKACEKELYGKSYTEQVLDRWIQATA 396
            ||   .:.||.||..|.:||.|:||.||:.|....|.:.:.|..:.|.  ||.:.:||.:..:..
Zfish   192 CE---RSLICEYGDNCTKAHSQEELQEWQTRVRAVRNKARDAASQGLL--SYQDNLLDEYRHSKD 251

  Fly   397 PERVMCERVPDMEARCEQQL-VTSISSKTSKREWLFQLETKKPLKAVALLQDAHRNHFALKSIKM 460
            .:.:|.:.:||:...|::.| ...:..:..:..|.|.:.:|:||:.:|||:......|:|..   
Zfish   252 KKMIMTDTIPDVFITCDRDLDAVYVRKRGIQCTWNFTIISKEPLEVIALLRREQGAKFSLSK--- 313

  Fly   461 CKPTESSMELKSDQEWLAGSSSQSETSNEDSATLIHEITVEFHTEIYGTFRQAICFDVGQEPLLV 525
                      |.|:|....:|:..|...|.:.   |||.|.|.::..|.:.|.:.||....|:|.
Zfish   314 ----------KPDEERSYSTSAWFEKRTEQTG---HEIPVSFRSDQPGLYEQWVVFDFNTRPVLR 365

  Fly   526 RHLCVDVLPVNDAEKIEEIKRDIINSSATRWDVANTQLTRFET-TIGTHLKTEAYLSDLEHEREL 589
            :.|.|.| ..:|.:.....:..:.|..|    ..|.:....|: ||...::||      :.:|:|
Zfish   366 QKLKVRV-GEDDCQAAPAPEALLENPEA----ACNLEPWNEESMTIIPFVETE------KAQRDL 419

  Fly   590 LERYPCPRAATFTLTQSTIVEKRLTQNNYRSRIHELLSVEEIARYEQIARYNVRTRLTVASNYIL 654
            |.||.       .:..:..:...:.:.||:..:|..|..||....|.::|.::|..:.:.:....
Zfish   420 LNRYQ-------LIMMNQQMNGLINRENYKWSMHNFLYQEEKVVGELLSRLSLRGTVQLKNELSD 477

  Fly   655 TPAGMATSTAKYSLAGELFALMRLGKDISEDTSPGRLILSNC--SSVYISKPEDPDSKADPTKRA 717
            ...||     |::..|||||.:.|.:.::.|...|.::..:.  |.|.:.|..:   ...|    
Zfish   478 DRFGM-----KWAHPGELFAAVPLSQPLTPDAPQGFIVKRHAIRSLVRVVKNNE---YCGP---- 530

  Fly   718 VYEA--LIEDKGKNVIYLKLSAKCVEAMALQADTELEVDIQFQLNRMPYCEWHNAVDKITDFRLI 780
            :|||  |.:...:..::|:||.:|..|:.||...|.|:::|||:||:.:||.|.|:|.:.....:
Zfish   531 IYEAEFLKDAASETQVHLQLSKRCCAALNLQNGEEYEMEVQFQVNRLWFCEMHKAIDDLPRMDKV 595

  Fly   781 FP-ATELEPSIPWTPKKQWADSCEPKLNAKQREAVNAITTALSI-----KLPPILLIGPFGTGKT 839
            .| ......||.:       .|.|.:.|.||:.|::.:   |.:     .:||:|:.||||||||
Zfish   596 LPDLKNAHLSISF-------QSDEGEFNEKQQAAMDFV---LGVSDNRSSIPPLLIYGPFGTGKT 650

  Fly   840 YTLAQAIKQLLTQPEAKILICTHSNSAADLYIKEYLHPWIEEGLKEATPLRVYYHKRWSATVNGV 904
            .|||:..:.|:.||..|||||||:||:||||||.:.|.::..|...|.|||:...:...|:.:.:
Zfish   651 RTLAKMAQALVQQPHNKILICTHTNSSADLYIKAHFHEYVRNGQLHARPLRIKAMEIKLASTDFI 715

  Fly   905 VQKYCITDGVGN-FLRPTVEDIMRHRIVVVTLSISMELATLGLPKGLFTHIFLDEAAQAMECEAI 968
            ..:||......| |..|....:...|||:.|.|::.....:.||:..|:||.:|||:|.:||||:
Zfish   716 TLQYCHLSREANCFEFPDKAVLDSTRIVITTTSLARFFNDMKLPENYFSHILIDEASQMLECEAL 780

  Fly   969 MPLALANDSTRIVLAGDHMQMSPELFSAFAKERKLHISLLERLYDHYPSN-----FPCKILLCEN 1028
            |.|:||.::||:|||||||||.|:|||....:...| :||.||:.||.:.     ...:|:..||
Zfish   781 MALSLAGNNTRVVLAGDHMQMGPKLFSVRPDKCSEH-TLLNRLFYHYQAENSDVAKQSRIIFNEN 844

  Fly  1029 YRAHEAIIRFTSELFY---EQKLVASGKQPRHDRFYPLTFFTTRGEDVQDKNSTAFYNNAEVYEV 1090
            ||:.:.|:.|.|..||   ...:.|.|..|.|.:.:.|.|...|||...|..|.:::|..::..|
Zfish   845 YRSTKDIVDFVSTHFYVGRSDVIKARGNVPSHPQQHALQFHHVRGECCLDPMSMSWFNAEQIVRV 909

  Fly  1091 VERVSELRKRWPSAWGKLNDTSIGIMTPYSDQVFRIRSELRKRRMGGISVERVLNVQGKQFRAVF 1155
            |..:.|:.|.||..||..:..|:.::: ...||..||..||...:...:||...||||||||.:.
Zfish   910 VHILQEIMKEWPQEWGAADPESVCVLS-QGRQVLEIRYRLRLLGLPRFTVENAENVQGKQFRVIV 973

  Fly  1156 LSTVRTR-------RTCMPQGSAPGSASTTSIGDADADYGFLSNSKLLNTAITRAQSLVAVVGDP 1213
            :|||.|:       |||:.                     |.::.::|||.:|||||.:.||||.
Zfish   974 ISTVHTKDSLLETDRTCLE---------------------FFNDMRVLNTIMTRAQSQIFVVGDA 1017

  Fly  1214 VAL-C-SIGRCRKVWERFIEICDEHKSLFGLTWSNLRSQL 1251
            .|| | ..|.|.::|..:||.|...:|...||..:|:..|
Zfish  1018 AALSCHQFGMCWRLWRAYIEECINKESCHDLTLDSLKQDL 1057

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HelzNP_001261848.1 zf-CCCH 329..353 CDD:279036 10/23 (43%)
TIGR00376 657..1236 CDD:273041 212/606 (35%)
AAA 810..>886 CDD:99707 37/80 (46%)
AAA_12 1003..1213 CDD:289832 73/224 (33%)
helz2aXP_003198895.2 AAA_11 614..807 CDD:289831 84/195 (43%)
P-loop_NTPase 639..>683 CDD:304359 28/43 (65%)
DNA2 <741..1055 CDD:224037 124/336 (37%)
UvrD_C_2 817..1017 CDD:304668 72/221 (33%)
RNB 1338..1698 CDD:214935
AAA_11 2168..2405 CDD:289831
AAA_19 2176..2246 CDD:289986
P-loop_NTPase <2366..2438 CDD:304359
AAA_12 2414..2614 CDD:289832
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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