DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Helz and mov10b.2

DIOPT Version :9

Sequence 1:	NP_001261848.1	Gene:	Helz / 39613	FlyBaseID:	FBgn0036451	Length:	2103	Species:	Drosophila melanogaster
Sequence 2:	NP_001037805.1	Gene:	mov10b.2 / 555950	ZFINID:	ZDB-GENE-060526-371	Length:	1015	Species:	Danio rerio

Alignment Length:	941	Identity:	236/941 - (25%)
Similarity:	391/941 - (41%)	Gaps:	207/941 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 ARCEQQLVTSISSKTSKREWLFQLETKKPLKAVALLQDAHRNHF----ALKSIKMCKPTESSMEL 470
            |.|..|..|...|:...|....:||.::..:.:...:.:|...:    |.:..|..:||..|..
Zfish   204 ALCWLQYFTLEDSRKVTRNNPLRLEPREKYEVIVRFKSSHVGVYSATLAFEFKKNTQPTTRSFH- 267

  Fly   471 KSDQEWLAGSSSQSETSNEDSATLIHEITVEFH---------TEIYGTFRQAI-----C-FDVGQ 520
                                   ::..|..|:.         ||.|...|..|     | .|.|.
Zfish   268 -----------------------IVRFIEAEYRSKLAALLGPTEPYKPLRLNISEPENCIIDEGF 309

  Fly   521 EP-LLVRHLCVDVLPVN------DAEKIEEIKRDIINSSATRWDVANTQLTRFETTIGTHLKTEA 578
            .| ..:::..|:|||:.      |...:.|:.::..:|...|                      .
Zfish   310 PPDGYLQNFLVNVLPLGKYIPPPDTTILAELLKEDCSSRIFR----------------------G 352

  Fly   579 YLSDLEHERELLERYPCPRAATFTLTQSTIVEKRLTQNNYRSRIHELLSVEEIARYEQIARYNVR 643
            .|.||:                      ::::..||.:||..|...||.:||...:..|.||| :
Zfish   353 KLKDLQ----------------------SLLQSPLTFDNYAERFDLLLYLEECQMHVDIKRYN-K 394

  Fly   644 TRLTVASNYILTPAGM----ATSTAKYSLAGELFALMRLGKDISEDTSPGRLILSNCSSV--YIS 702
            ..:|:..:......|:    .:......|.|:...|.:     ||:.:     .||.:..  |:.
Zfish   395 DSVTLHRDRDKRLMGLNLPGVSENRPSVLRGDHLLLTK-----SEEVT-----FSNVTKYKGYVH 449

  Fly   703 KPEDPDSKADPTKRAVYEALIEDKGKNVIYLKLSAKCVEAMALQADTELEVDIQFQLNRMPYCEW 767
            :.|....|...:||.:.:..|:                         :::..::|.:||:|....
Zfish   450 RVELDQVKLGLSKRFLKDVYID-------------------------KMKFRVEFTVNRIPVRLQ 489

  Fly   768 HNAVDKITDFRL---IFP--ATELEPSIPWTPKKQWADSCEPKLNAKQREAVNAITTALSIKLPP 827
            |.||.......|   :||  :..|.|..|  |..:..|. :.:.|.:|..||..|....| |..|
Zfish   490 HRAVHMAVQHNLKDVLFPMASRSLNPVSP--PALRLFDR-KLEYNFQQYSAVCNIVAGTS-KPAP 550

  Fly   828 ILLIGPFGTGKTYTLAQAIKQLLTQ-PEAKILICTHSNSAADLYIKEYLHPWIEEGLKEATPLRV 891
            .|:.||.|||||.|:.:||||:... |:|.||.|..||||||...::.:   ..|.:......|:
Zfish   551 YLVFGPPGTGKTVTIVEAIKQVEKNIPDAYILACAPSNSAADQLCEKLI---TSEHVDAHKIYRL 612

  Fly   892 YYHKRWSATVNGVVQKYC-ITDGVGNFLRPTVEDIMRHRIVVVTLSISMELATLGLPKGLFTHIF 955
            |...|....:..:::..| :.:.:.:|  |..||:|.::|::.||..:..|.|.|..:..|||.|
Zfish   613 YASSRNQKDIPKILKDNCNVDEEMIDF--PCKEDLMSYKILICTLVTAGRLVTGGFSEDHFTHNF 675

  Fly   956 LDEAAQAMECEAIMPLA--LANDSTRIVLAGDHMQMSPELFSAFAKERKLHISLLERLYD----- 1013
            :|||..|:|.|.|:.:|  |..:..::|||||..|:.|.|.|..|....|.:||||||..
Zfish   676 VDEAGHAVESETIISVAGLLNAEKGQLVLAGDPKQLGPILRSPLAINHGLDVSLLERLMTQNDLY 740

  Fly  1014 -----HYPSNFPCKILLCENYRAHEAIIRFTSELFYEQKLVASGKQPRHDRF----------YPL 1063
                 .:.:.:..|:::  |||:|..|:...:.|||:.:|.|...:...:::          :|:
Zfish   741 KRGDVEFDNRYVSKLIM--NYRSHPYILEVPNRLFYDGELKACADEISSNQYCMWEHLPSKGFPV 803

  Fly  1064 TFFTTRGEDVQDKNSTAFYNNAEVYEVVERVSELRKRWP-SAWGKLNDTSIGIMTPYSDQVFRIR 1127
            .|....|:|.::.||.:|:|..|:..:|:.:.:|....| ....::....|||:.||..||.:|:
Zfish   804 IFHGVPGKDERESNSPSFFNIYEINILVDYLKKLLLTQPKKGISRIFPKDIGIIAPYRKQVEKIK 868

  Fly  1128 SELRKRR-----MG--GISVERVLNVQGKQFRAVFLSTVRTRRTCMPQGSAPGSASTTSIGDADA 1185
            ..:...:     ||  .:.|..|...||::.:.:.:||||:            |....|: |...
Zfish   869 RAIDADKDFQDYMGIDNLKVGSVEEFQGQERKVIMVSTVRS------------SVKYISL-DETF 920

  Fly  1186 DYGFLSNSKLLNTAITRAQSLVAVVGDPVALCSIGRCRKVWERFIEICDEHKSLFGLTWSNLRSQ 1250
            :.|||.|.|..|.|:|||:||:.:||:|:.|    |..:.|.|||:.|.|.....|::.::: .:
Zfish   921 NIGFLKNEKRFNVAVTRAKSLLIMVGNPMIL----RTDESWGRFIDFCLERGGYTGISITSV-ER 980

  Fly  1251 LDGVELKRGYVLNPLAPEF----VPRALQPE 1277
            :|.|| .|...||....|.    |.|.:.||
Zfish   981 IDDVE-SRLLALNIQDEETEESPVQRYVDPE 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Helz	NP_001261848.1	zf-CCCH	329..353	CDD:279036
		TIGR00376	657..1236	CDD:273041	173/621 (28%)
		AAA	810..>886	CDD:99707	32/76 (42%)
		AAA_12	1003..1213	CDD:289832	65/237 (27%)
mov10b.2	NP_001037805.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..130
		MYCBPAP	<189..>262	CDD:291319	11/57 (19%)
		AAA_11	552..718	CDD:289831	61/170 (36%)
		P-loop_NTPase	552..>714	CDD:304359	59/166 (36%)
		DNA2	<642..983	CDD:224037	107/360 (30%)
		DEAG box	677..680		2/2 (100%)
		AAA_12	725..948	CDD:289832	65/237 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820