Protein Alignment Helz and mov10b.2

DIOPT Version :10

• Sequence 1: NP_648725.2
• Gene: Helz / 39613
• FlyBaseID: FBgn0036451
• Length: 2103
• Species: Drosophila melanogaster
• Sequence 2: NP_001037805.1
• Gene: mov10b.2 / 555950
• ZFINID: ZDB-GENE-060526-371
• Length: 1015
• Species: Danio rerio
• Alignment Length: 941
• Identity: 236/941 - (25%)
• Similarity: 391/941 - (41%)
• Gaps: 207/941 - (21%)

  Fly   410 ARCEQQLVTSISSKTSKREWLFQLETKKPLKAVALLQDAHRNHF----ALKSIKMCKPTESSMEL 470
            |.|..|..|...|:...|....:||.::..:.:...:.:|...:    |.:..|..:||..|..
Zfish   204 ALCWLQYFTLEDSRKVTRNNPLRLEPREKYEVIVRFKSSHVGVYSATLAFEFKKNTQPTTRSFH- 267

  Fly   471 KSDQEWLAGSSSQSETSNEDSATLIHEITVEFH---------TEIYGTFRQAI-----C-FDVGQ 520
                                   ::..|..|:.         ||.|...|..|     | .|.|.
Zfish   268 -----------------------IVRFIEAEYRSKLAALLGPTEPYKPLRLNISEPENCIIDEGF 309

  Fly   521 EP-LLVRHLCVDVLPVN------DAEKIEEIKRDIINSSATRWDVANTQLTRFETTIGTHLKTEA 578
            .| ..:::..|:|||:.      |...:.|:.::..:|...|                      .
Zfish   310 PPDGYLQNFLVNVLPLGKYIPPPDTTILAELLKEDCSSRIFR----------------------G 352

  Fly   579 YLSDLEHERELLERYPCPRAATFTLTQSTIVEKRLTQNNYRSRIHELLSVEEIARYEQIARYNVR 643
            .|.||:                      ::::..||.:||..|...||.:||...:..|.||| :
Zfish   353 KLKDLQ----------------------SLLQSPLTFDNYAERFDLLLYLEECQMHVDIKRYN-K 394

  Fly   644 TRLTVASNYILTPAGM----ATSTAKYSLAGELFALMRLGKDISEDTSPGRLILSNCSSV--YIS 702
            ..:|:..:......|:    .:......|.|:...|.:     ||:.:     .||.:..  |:.
Zfish   395 DSVTLHRDRDKRLMGLNLPGVSENRPSVLRGDHLLLTK-----SEEVT-----FSNVTKYKGYVH 449

  Fly   703 KPEDPDSKADPTKRAVYEALIEDKGKNVIYLKLSAKCVEAMALQADTELEVDIQFQLNRMPYCEW 767
            :.|....|...:||.:.:..|:                         :::..::|.:||:|....
Zfish   450 RVELDQVKLGLSKRFLKDVYID-------------------------KMKFRVEFTVNRIPVRLQ 489

  Fly   768 HNAVDKITDFRL---IFP--ATELEPSIPWTPKKQWADSCEPKLNAKQREAVNAITTALSIKLPP 827
            |.||.......|   :||  :..|.|..|  |..:..|. :.:.|.:|..||..|....| |..|
Zfish   490 HRAVHMAVQHNLKDVLFPMASRSLNPVSP--PALRLFDR-KLEYNFQQYSAVCNIVAGTS-KPAP 550

  Fly   828 ILLIGPFGTGKTYTLAQAIKQLLTQ-PEAKILICTHSNSAADLYIKEYLHPWIEEGLKEATPLRV 891
            .|:.||.|||||.|:.:||||:... |:|.||.|..||||||...::.:   ..|.:......|:
Zfish   551 YLVFGPPGTGKTVTIVEAIKQVEKNIPDAYILACAPSNSAADQLCEKLI---TSEHVDAHKIYRL 612

  Fly   892 YYHKRWSATVNGVVQKYC-ITDGVGNFLRPTVEDIMRHRIVVVTLSISMELATLGLPKGLFTHIF 955
            |...|....:..:::..| :.:.:.:|  |..||:|.::|::.||..:..|.|.|..:..|||.|
Zfish   613 YASSRNQKDIPKILKDNCNVDEEMIDF--PCKEDLMSYKILICTLVTAGRLVTGGFSEDHFTHNF 675

  Fly   956 LDEAAQAMECEAIMPLA--LANDSTRIVLAGDHMQMSPELFSAFAKERKLHISLLERLYD----- 1013
            :|||..|:|.|.|:.:|  |..:..::|||||..|:.|.|.|..|....|.:||||||..
Zfish   676 VDEAGHAVESETIISVAGLLNAEKGQLVLAGDPKQLGPILRSPLAINHGLDVSLLERLMTQNDLY 740

  Fly  1014 -----HYPSNFPCKILLCENYRAHEAIIRFTSELFYEQKLVASGKQPRHDRF----------YPL 1063
                 .:.:.:..|:::  |||:|..|:...:.|||:.:|.|...:...:::          :|:
Zfish   741 KRGDVEFDNRYVSKLIM--NYRSHPYILEVPNRLFYDGELKACADEISSNQYCMWEHLPSKGFPV 803

  Fly  1064 TFFTTRGEDVQDKNSTAFYNNAEVYEVVERVSELRKRWP-SAWGKLNDTSIGIMTPYSDQVFRIR 1127
            .|....|:|.::.||.:|:|..|:..:|:.:.:|....| ....::....|||:.||..||.:|:
Zfish   804 IFHGVPGKDERESNSPSFFNIYEINILVDYLKKLLLTQPKKGISRIFPKDIGIIAPYRKQVEKIK 868

  Fly  1128 SELRKRR-----MG--GISVERVLNVQGKQFRAVFLSTVRTRRTCMPQGSAPGSASTTSIGDADA 1185
            ..:...:     ||  .:.|..|...||::.:.:.:||||:            |....|: |...
Zfish   869 RAIDADKDFQDYMGIDNLKVGSVEEFQGQERKVIMVSTVRS------------SVKYISL-DETF 920

  Fly  1186 DYGFLSNSKLLNTAITRAQSLVAVVGDPVALCSIGRCRKVWERFIEICDEHKSLFGLTWSNLRSQ 1250
            :.|||.|.|..|.|:|||:||:.:||:|:.|    |..:.|.|||:.|.|.....|::.::: .:
Zfish   921 NIGFLKNEKRFNVAVTRAKSLLIMVGNPMIL----RTDESWGRFIDFCLERGGYTGISITSV-ER 980

  Fly  1251 LDGVELKRGYVLNPLAPEF----VPRALQPE 1277
            :|.|| .|...||....|.    |.|.:.||
Zfish   981 IDDVE-SRLLALNIQDEETEESPVQRYVDPE 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Helz	NP_648725.2	zf-CCCH	329..353	CDD:459885
		DEXXQc_HELZ	805..1030	CDD:350835	80/238 (34%)
		DNA2	<925..1236	CDD:440729	103/340 (30%)
mov10b.2	NP_001037805.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	94..130
		DEXXQc_Helz-like	531..760	CDD:350796	80/236 (34%)
		DEAG box	677..680		2/2 (100%)
		AAA_12	725..948	CDD:463780	65/237 (27%)