Protein Alignment Helz and helz2c

DIOPT Version :10

• Sequence 1: NP_648725.2
• Gene: Helz / 39613
• FlyBaseID: FBgn0036451
• Length: 2103
• Species: Drosophila melanogaster
• Sequence 2: NP_001428512.1
• Gene: helz2c / 552926
• ZFINID: ZDB-GENE-050508-3
• Length: 1546
• Species: Danio rerio
• Alignment Length: 1275
• Identity: 242/1275 - (18%)
• Similarity: 428/1275 - (33%)
• Gaps: 411/1275 - (32%)

  Fly   103 LFKMHKYGDAEIFLSKWINELSGQQIYSDISKTLERYKSIIQMIMNG---QHKAQALKIPHARLE 164
            |.||.::..:..:.|      ..|.|:||     |.:.:::.|:.:.   :.||..|:...:: |
Zfish   491 LHKMEEFAQSRDYYS------LTQLIFSD-----EIHPTLVPMVRDFREIKRKAVILRSCTSK-E 543

  Fly   165 DEMAILDTKLDHWATNNLPLDKYSKLLSNKGLKKREQQQQQQQQQQQQNGNGIGSYASSSSSSST 229
            ..:...|.:::.:...:.|:.:|..|:..:.|  .....:|..:|.....:.|..|..|...:..
Zfish   544 SRLGHYDLQMNAYTWASSPMRRYLDLIVQRLL--HTMLSKQYLKQADYTNDEINRYCLSGMEAEE 606

  Fly   230 GSSSTMSSSSTSLHKTNDL--LAAMKLTAGKHQPGSGDGSGSDQGDQAAPSTTCSYCTITFQTRN 292
            ...:.:........:..|:  ||.:                    ||..|..  ....|:|..:.
Zfish   607 EQDALVFRLRKIQFEPRDVVNLATV--------------------DQITPKG--HEFIISFPLQP 649

  Fly   293 ELRQHCQTEAHQKVIMSDEGRDWKWRPPPRGYTLDTYSLCETFSEAHICHYGAQCVEAHGQDELN 357
            .|........|.||:  |:.   |:.......||.......||.|.
Zfish   650 SLDLITIMYKHLKVV--DQP---KYNEDKNSMTLHWKRRVYTFGEV------------------- 690

  Fly   358 EWKERFEYRRMRMQKACEKELYGKSYTEQVLDRWIQ-ATAPERVMCERVPDMEARCEQQLVTSIS 421
             :|.||....|:........|:.:..:......|.: ....:.:..|..|:||....:...|..:
Zfish   691 -FKNRFPSNPMKNVTPVSSILWKRLISAVKHQDWAKIEQCFQNIKREEKPEMEKLISEASSTQEN 754

  Fly   422 SKTSKREWLFQLETK----------------KPLKAVALLQ---------DAHRNHFALKSIKMC 461
            ||...:|  ..||.|                .|:..|.||.         :..||.....|..:|
Zfish   755 SKMHYKE--LNLELKLGDVVQVQLGSEFKDGLPVPVVQLLSVNECFEICLEHSRNPTLCFSDSVC 817

  Fly   462 KPTESSMELKSDQEWLAGSSSQSETS----NEDSATLIHEITVEFHTEI--YGTFRQAICFDVGQ 520
            ..::.|.|...:.:.:.....|.:|:    .|:::.::.|:.:.:..||  .|.|
Zfish   818 IASKISYESYEEYQKIWTQLCQIDTAYNALEENNSVILEEVFINWSDEINLQGFF---------- 872

  Fly   521 EPLLVRHLCVDVLPVNDAEKIEEIKRDIINSSATRW----DVANTQL------TRFETTIGTHLK 575
                  ||                    ..:..|:|    |:.|..|      .:.:..:|.|:.
Zfish   873 ------HL--------------------TKTQKTQWSLEFDLTNCFLCIRLRRQKLDENLGKHID 911

  Fly   576 TEAYLSDLEHERELLERYPCPRAATFTLTQSTIVEKRLTQN-NYRSRIHELLSVEEIARYEQIAR 639
            ..| :|||:            ....||.....:..|...:: |.:.||:..::...:. |.....
Zfish   912 RSA-VSDLQ------------GCLPFTWVAHAVTTKSKKKDANTKGRINFKITHRSMT-YIPARI 962

  Fly   640 YNVRTRLTVASNYILTPAGMATSTAKYSLAGELFALMRLGKDISEDTSPGRLILSNCSSVYISKP 704
            :|..|:.|:.         :......|.|..:..|.::...::.:..:.|:|.|::
Zfish   963 FNKGTKFTIE---------VIPKKIPYLLREQAVANLKRANNLVKSVATGKLELND--------- 1009

  Fly   705 EDPDSKADPTKRAVYEALIEDKGKNVIYLKLSAKCVEAMALQADTELEVDIQFQLNRMPYCEWHN 769
                 .||....::|:.   ||..|:
Zfish  1010 -----DADLRNISLYDV---DKSLNL--------------------------------------- 1027

  Fly   770 AVDKITDFRLIFPATELEPSIPWTPKKQWADSCEPKLNAKQREAVNAITTALSIKLPPILLIGPF 834
                                              |.||..|::||..     ::|.|..::.||.
Zfish  1028 ----------------------------------PTLNMSQKKAVKE-----AMKKPFTVIQGPP 1053

  Fly   835 GTGKTYTLAQAIKQLL--------------TQPEAK------ILICTHSNSAADLYIKEYLHPWI 879
            |||||......:.|..              |.|:..      ||.|..||.:.|:..::.|.  :
Zfish  1054 GTGKTVVGIHIVFQFFKKNKDFMTSFKPNHTNPDGNPPKKPAILYCGPSNKSVDIVAEQLLK--L 1116

  Fly   880 EEGLKEATPLRVY--------------------------------------YHKR-----WSATV 901
            ...||   |||:|                                      |..|     :|..:
Zfish  1117 SGVLK---PLRIYCDQMEMREFPYTGSELKLCRRSLRDEKPKEELRDITLMYLVRKPENPFSEEI 1178

  Fly   902 NGVVQKYCITDGVGNF----LRPTVEDIMRHRIVVVTLSISMELATLGLPKGLFTHIFLDEAAQA 962
            . .::|....|.:.|:    .:....:|.::.:|:.|.|.:::.....:..  |..|.:||.|.|
Zfish  1179 K-ALEKNLSVDQIDNYRKLLKKANQHEIEKYDVVLCTCSSALKPELREVMD--FRQILIDECAMA 1240

  Fly   963 MECEAIMPLALANDSTRIVLAGDHMQMSPELFSAFAKERKLHISLLERLYDHYPSNFPCKILLCE 1027
            .|.||.:|| ::::..:|||.|||.|:.|.:.....|.:.:..||.||..|       ...:|..
Zfish  1241 TEPEAFIPL-VSHNPQQIVLLGDHQQIRPIVQCGHVKNKGMEKSLFERYMD-------LANMLDT 1297

  Fly  1028 NYRAHEAIIRFTSELFYEQK-----------LVASGKQPRHDRFYPLTFFTTRGEDVQ------- 1074
            .||.|..|..|.|:.||:.|           |:...|:|.     .:.|....|::|.
Zfish  1298 QYRMHAEICSFPSDEFYDGKLKTGAERGPCCLLNKSKEPT-----AMLFGHIEGKEVSLVVSTEK 1357

  Fly  1075 -DKNSTAFYNNAEVYEVVERVSELRKRWPSAWGKLNDTSIGIMTPYSDQVFRIRSELRKRRMGGI 1138
             ::||.|   |.|..|....|::|..:...    ::...|.|:|||:.||..|:..|.|:.:..:
Zfish  1358 GNENSMA---NTEEAEQAVCVADLLIKQSG----VSPEHIAILTPYNAQVSEIKMTLEKKNVRNV 1415

  Fly  1139 SVERVLNVQGKQFRAVFLSTVRTRRTCMPQGSAPGSASTTSI------------GDADADYGFLS 1191
            :|..|:..||.::..|.:||||             |.||:.|            |..   .||::
Zfish  1416 TVCTVMKSQGSEWPYVIVSTVR-------------SCSTSDIQAYRVRPHKAWLGKR---LGFVT 1464

  Fly  1192 NSKLLNTAITRAQSLVAVVGDPVALCSIGRCRKVWERFIE 1231
            ::..:|.||||||..:.::|:...|    ||.::|:|.::
Zfish  1465 DANQVNVAITRAQDGLCILGNSDLL----RCCELWDRLLD 1500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Helz	NP_648725.2	zf-CCCH	329..353	CDD:459885	3/23 (13%)
		DEXXQc_HELZ	805..1030	CDD:350835	66/291 (23%)
		DNA2	<925..1236	CDD:440729	92/338 (27%)
helz2c	NP_001428512.1	None