DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Helz and MOV10L1

DIOPT Version :9

Sequence 1:	NP_001261848.1	Gene:	Helz / 39613	FlyBaseID:	FBgn0036451	Length:	2103	Species:	Drosophila melanogaster
Sequence 2:	XP_011528998.1	Gene:	MOV10L1 / 54456	HGNCID:	7201	Length:	1256	Species:	Homo sapiens

Alignment Length:	846	Identity:	232/846 - (27%)
Similarity:	352/846 - (41%)	Gaps:	222/846 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   514 ICFDVGQEPLLVRHLCVDVLPVNDAEKIEEIKRDIINSSATRWD--VANTQLTRFETTIGTHLKT 576
            :||   .:.|:.|:|.|:|  ::..|.:      |.......|.  .::..||..:||:   :.|
Human   431 LCF---SDFLIGRYLEVNV--ISGEESL------IAAREPFSWKKLKSSQALTSAKTTV---VVT 481

  Fly   577 EAYLSDLEHERELLERYP-------CPRAATFTLTQSTIVEKRLTQNNYRSRIHELLSVEEIARY 634
            ....:........|.:||       |.......||...::.:.|..:||:.:...||.:|||...
Human   482 AQKRNSRRQLPSFLPQYPIPDRLRKCVEQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIYAE 546

  Fly   635 EQIARYNVRTRLTVASN---YILTPAGMATSTAKYSL-AGELFALMRLGKDISEDTSPGRLILS- 694
            .::..||: :.:.:..|   .:|...|:|  ..:.|| ||:                  :|||.
Human   547 MELKEYNM-SGIILRRNGDLLVLEVPGLA--EGRPSLYAGD------------------KLILKT 590

  Fly   695 ---NCSSV-YIS-----KPEDPDSKADP--------------------TKRAVYEALIEDKGKNV 730
               |..:: |||     ..||...|.:|                    |.|..:.||     ::|
Human   591 QEYNGHAIEYISYVTEIHEEDVTLKINPEFEQAYNFEPMDVEFTYNRTTSRRCHFAL-----EHV 650

  Fly   731 IYLKLSAKCVEAMALQA-----------DTELEVDIQFQLNRMPY-------CEWHNAVDKITDF 777
            |:|.:.....|.:.||:           ||:.......:.||...       .|.....||  |.
Human   651 IHLGVKVLFPEEIILQSPQVTGNWNHAQDTKSSGQSTSKKNRKTMTDQAEHGTEERRVGDK--DL 713

  Fly   778 RLIFPATELEPSIPW-----TPKKQWADSCEPKLNAKQREAVNAITTALSIKLPPILLIGPFGTG 837
            .::.|.| .|.| .|     |||.:..:...|.||..|:.||..|.:. ..:..|.:|.||.|||
Human   714 PVLAPFT-AEMS-DWVDEIQTPKARKMEFFNPVLNENQKLAVKRILSG-DCRPLPYILFGPPGTG 775

  Fly   838 KTYTLAQAIKQL-LTQPEAKILICTHSNSAADLYIKEYLHPWIEEGLKEATPLRVYYHKRWSATV 901
            ||.|:.:|:.|: ...|:::||:|..|||||||.... ||.  .:.|:.||.:||....|:...|
Human   776 KTVTIIEAVLQVHFALPDSRILVCAPSNSAADLVCLR-LHE--SKVLQPATMVRVNATCRFEEIV 837

  Fly   902 NGVVQKYCITDGVGNFLRPTVEDI---MRHRIVVVTLSISMELATLGLPKGLFTHIFLDEAAQAM 963
            ...|:.|| .||         |||   .|.||::.|.|.|.....:|:..|.|||:|:|||.||.
Human   838 IDAVKPYC-RDG---------EDIWKASRFRIIITTCSSSGLFYQIGVRVGHFTHVFVDEAGQAS 892

  Fly   964 ECEAIMPLALAND-STRIVLAGDHMQMSPELFSAFAKERKLHISLLERL-----YDHYPSNF--- 1019
            |.|.::||.|.:| |.:||||||.||:.|.:.|..|....|::|.||||     |....:.|
Human   893 EPECLIPLGLMSDISGQIVLAGDPMQLGPVIKSRLAMAYGLNVSFLERLMSRPAYQRDENAFGAC 957

  Fly  1020 ----PCKIL-LCENYRAHEAIIRFTSELFYEQKL--------VAS--GKQPRHDRFYPLTFFTTR 1069
                |..:. |.:|||:|||::...|.|||.::|        |.|  |.:....:.:||.|...|
Human   958 GAHNPLLVTKLVKNYRSHEALLMLPSRLFYHRELEVCADPTVVTSLLGWEKLPKKGFPLIFHGVR 1022

  Fly  1070 GEDVQDKNSTAFYNNAEVYEVVERVSELRKRWPSAWGKLNDTSIGIMTPY--------------- 1119
            |.:.::..|.:::|.||..:|:.....|..   |...:::.:.||::|||
Human  1023 GSEAREGKSPSWFNPAEAVQVLRYCCLLAH---SISSQVSASDIGVITPYRKQWLWSSGGDTGAS 1084

  Fly  1120 ------------------------------SDQVFRIRSELRKRRMGGISVERVLNVQGKQFRAV 1154
                                          .::|.:||..||...:..|.|..|...||:::..:
Human  1085 HAEHQVSFMKHVSLWCSHHQAELGKNPQNTEEKVEKIRILLRNVDLMDIKVGSVEEFQGQEYLVI 1149

  Fly  1155 FLSTVRTRRTCMPQGSAPGSASTTSIGDADAD----YGFLSNSKLLNTAITRAQSLVAVVGDPVA 1215
            .:||||:..                  |...|    .|||||||..|.||||.::|:.|:|:|..
Human  1150 IISTVRSNE------------------DRFEDDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHV 1196

  Fly  1216 L 1216
            |
Human  1197 L 1197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Helz	NP_001261848.1	zf-CCCH	329..353	CDD:279036
		TIGR00376	657..1236	CDD:273041	199/691 (29%)
		AAA	810..>886	CDD:99707	30/76 (39%)
		AAA_12	1003..1213	CDD:289832	72/281 (26%)
MOV10L1	XP_011528998.1	DNA2	426..1217	CDD:224037	232/846 (27%)
		P-loop_NTPase	744..>922	CDD:304359	78/191 (41%)
		AAA_12	933..1194	CDD:289832	72/281 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920