DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Helz and MOV10

DIOPT Version :9

Sequence 1:	NP_001261848.1	Gene:	Helz / 39613	FlyBaseID:	FBgn0036451	Length:	2103	Species:	Drosophila melanogaster
Sequence 2:	NP_001123551.1	Gene:	MOV10 / 4343	HGNCID:	7200	Length:	1003	Species:	Homo sapiens

Alignment Length:	794	Identity:	216/794 - (27%)
Similarity:	338/794 - (42%)	Gaps:	175/794 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   582 DLEHERELLERYPCPRAATF--TLTQSTIV--------------EKRLTQNNYRSRIHELLSVEE 630
            |||....|...||.||....  .|.|.|.:              |..|...||..::..||.:||
Human   284 DLELSMALGTYYPPPRLRQLLPMLLQGTSIFTAPKEIAEIKAQLETALKWRNYEVKLRLLLHLEE 348

  Fly   631 IARYEQIARYNVRT------------RLTVASNYILTPAGMATSTAKYSLAGELFALMRLGKDIS 683
            :.....|..|::.:            ||..     |...|:..|.........||||      :|
Human   349 LQMEHDIRHYDLESVPMTWDPVDQNPRLLT-----LEVPGVTESRPSVLRGDHLFAL------LS 402

  Fly   684 EDTSPGRLILSNCSSVYISKPEDPDSKADPTKRAVYEALIE----DKGKNVIYLKLSAKCVEAMA 744
            .:|                ..|||         ..|:..:.    |:.|....:.|.::.|:.:.
Human   403 SET----------------HQEDP---------ITYKGFVHKVELDRVKLSFSMSLLSRFVDGLT 442

  Fly   745 LQADTELEVDIQFQLNRMPYCEWHNAVDKITD----FRLIFPATELE-PSIPWTPK-KQWADSCE 803
            .:        :.|..||.|....|.|:: :|.    :.::||....: |.:|...| |.:..|.|
Human   443 FK--------VNFTFNRQPLRVQHRALE-LTGRWLLWPMLFPVAPRDVPLLPSDVKLKLYDRSLE 498

  Fly   804 PKLNAKQREAVNAITTALSIKLPPILLIGPFGTGKTYTLAQAIKQLLTQ-PEAKILICTHSNSAA 867
            .  |.:|.:|:..|.|. :.:..|.::.||.|||||.||.:||||::.. |:|.||.|..|||.|
Human   499 S--NPEQLQAMRHIVTG-TTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGA 560

  Fly   868 DLYIKEYLHPWIEEGLKEATPLRVYYHKRWSATVNGV---VQKYCITDG-VGNFLRPTVEDIMRH 928
            ||..:.         |:...|..:|.....|..:..|   ::..|..|. .|.::.|..:.:..:
Human   561 DLLCQR---------LRVHLPSSIYRLLAPSRDIRMVPEDIKPCCNWDAKKGEYVFPAKKKLQEY 616

  Fly   929 RIVVVTLSISMELATLGLPKGLFTHIFLDEAAQAMECEAIMPLA-------LANDSTRIVLAGDH 986
            |:::.||..:..|.:...|...|||||:|||...||.|:::.:|       ..:...::|||||.
Human   617 RVLITTLITAGRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKETGDPGGQLVLAGDP 681

  Fly   987 MQMSPELFSAFAKERKLHISLLERLY----------DHYPSNFPCKILLCENYRAHEAIIRFTSE 1041
            .|:.|.|.|...::..|..||||||.          |.|...|..|:|  .|||:|..|:...::
Human   682 RQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDGYDPQFITKLL--RNYRSHPTILDIPNQ 744

  Fly  1042 LFYEQKLVASGKQPRHDRF----------YPLTFFTTRGEDVQDKNSTAFYNNAEVYEVVERVSE 1096
            |:||.:|.|.......:||          :|:.|....|:|.::.||.:|:|..|...|...:..
Human   745 LYYEGELQACADVVDRERFCRWAGLPRQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKL 809

  Fly  1097 LRKRWPSA---WGKLNDTSIGIMTPYSDQVFRIRSELRK--RRMGG------ISVERVLNVQGKQ 1150
            |..  ||:   ..:|:..|:|:::||..||.:||..:.|  |.:.|      :.|..|...||::
Human   810 LLA--PSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQE 872

  Fly  1151 FRAVFLSTVRTRRTCMPQGSAPGSASTTSIGDADADYGFLSNSKLLNTAITRAQSLVAVVGDPVA 1215
            ...:.:||||:            |.|...: |.|.:.|||.|.|..|.|:|||::|:.:||:|:.
Human   873 RSVILISTVRS------------SQSFVQL-DLDFNLGFLKNPKRFNVAVTRAKALLIIVGNPLL 924

  Fly  1216 LCSIGRCRKVWERFIEICDEHKSLFGLTWSNLRSQLD---GVELKRGYVLNPLAP--------EF 1269
            |   |. ...|:.|:|.|.|:.   |.|.....::||   |..|.:|  |:.|:|        ::
Human   925 L---GH-DPDWKVFLEFCKENG---GYTGCPFPAKLDLQQGQNLLQG--LSKLSPSTSGPHSHDY 980

  Fly  1270 VPRALQPEAYLREQ 1283
            :|:..:.|..|..|
Human   981 LPQEREGEGGLSLQ 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Helz	NP_001261848.1	zf-CCCH	329..353	CDD:279036
		TIGR00376	657..1236	CDD:273041	177/631 (28%)
		AAA	810..>886	CDD:99707	30/76 (39%)
		AAA_12	1003..1213	CDD:289832	74/240 (31%)
MOV10	NP_001123551.1	DEXXQc_Helz-like	498..733	CDD:350796	79/248 (32%)
		DEAG box	645..648		2/2 (100%)
		SF1_C_Upf1	734..939	CDD:350195	65/223 (29%)
		Interaction with AGO2 and APOBEC3G. /evidence=ECO:0000269\|PubMed:22791714	921..965		15/52 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	966..1003		6/29 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820