DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Helz and helz

DIOPT Version :9

Sequence 1:NP_001261848.1 Gene:Helz / 39613 FlyBaseID:FBgn0036451 Length:2103 Species:Drosophila melanogaster
Sequence 2:XP_021325743.1 Gene:helz / 406550 ZFINID:ZDB-GENE-040426-2419 Length:1864 Species:Danio rerio


Alignment Length:2137 Identity:732/2137 - (34%)
Similarity:1029/2137 - (48%) Gaps:512/2137 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   205 QQQQQQQQNGNGIGSYASSSSSSSTGSSS--------TMSSSSTSLHKTNDLL----AAMKL--- 254
            :.::.|:.....|||.......::...|:        ...:.||:|.:|..||    |.::|   
Zfish     2 EDRRPQKSCDEAIGSLVRQEYEAAVAHSTEALLAMGPRTPTPSTALLRTRALLYRIAARLQLKDY 66

  Fly   255 ----TAGKH----QPGSGDGS-----------GSDQGDQAAPSTTCSYCTIT--------FQTRN 292
                ...||    :...||||           ||.|       ..||..:..        ..|::
Zfish    67 DQADEDCKHVFAEELAKGDGSFRAGLQSLLLDGSLQ-------EVCSVLSKALYGEPLNGIMTKD 124

  Fly   293 ELR-QHCQTE---AHQKVIMSDEGRD-----WKWRPPPRGYT-LDTYSLCETFSEAHICHYGAQC 347
            ..| :...:|   |..||:.|:|..:     |::||||||.| .:.|:||:.|.|..:|.|||||
Zfish   125 MTRLKRLLSEIEAARSKVVFSEENEEDVQEGWQFRPPPRGVTSSEEYTLCKRFLEQGLCRYGAQC 189

  Fly   348 VEAHGQDELNEWKERFEYRRMRMQKACEKELYGKSYTEQVLDRWIQATAPERVMCERVPDMEARC 412
            ..||.|:||.||:.|:..|.:|:::..|.:.:.::|.|.::::||.:..|||||.:.|..:....
Zfish   190 TSAHSQEELTEWQRRYASRLIRLKQQQEGKHFSENYMEALIEKWINSLTPERVMNDCVDGVTVEH 254

  Fly   413 EQQLVTSISSKTSKREWLFQLETK--KPLKAVALLQDAHRNHFALKSIKMCKPTESSMELK---- 471
            ...|..::::|.|...|.|.|..|  :.|:.:|||.||:|.||::.::.  ....|::|.:    
Zfish   255 SSDLSITVNTKKSSHSWTFTLFCKPVRTLQRIALLYDANRPHFSIAAVS--AGDASALEPQPVCP 317

  Fly   472 -SDQEWLAGSSSQSETSNEDSATLIHEITVEFHTEIYGTFRQAICFDVGQEPLLVRHLCVDVLPV 535
             ..|||.|.|..|:...:     .|:.:.:.|.|||:|||||.:.||:|.||:|::.:.||...:
Zfish   318 GGCQEWSAASPVQNGMDH-----CIYTVEIAFSTEIFGTFRQTVVFDLGCEPVLMQRVMVDAASI 377

  Fly   536 NDAEKIEEIKRDIINSSATRWDVANTQLTRFETTIGTHLKTEAYLSDLEHERELLERYPCPRAAT 600
            .|.|.:.:.::.:: .:|.|||.:...:..|...           .:::.||.||.||..|.:|.
Zfish   378 EDLEHLLQARQQLL-MTAKRWDSSCKTIVEFVPN-----------ENMDLERSLLTRYQIPLSAD 430

  Fly   601 FTLTQSTIVEKRLTQNNYRSRIHELLSVEEIARYEQIARYNVRTRLTVASNYILTPAGMATSTAK 665
            ...||| :::|.||::||:.|:|:||.:||||:|::::::|::..|.:.::::||  |: :..||
Zfish   431 QLFTQS-VLDKTLTRDNYQPRLHDLLYIEEIAQYKEVSKFNIKVNLQLVTSFMLT--GI-SGGAK 491

  Fly   666 YSLAGELFALMRLGKDISEDTSPGRLILSNCSSVY---ISKPEDPDSKADPTKRAVYEALIEDKG 727
            |:..|:|||..:|.:.:||||..|||:::..:||.   :.|.....::....|..|||||||:|.
Zfish   492 YAQNGQLFARFKLTETLSEDTLAGRLVMTKVNSVLLLPVFKERMGQNQPAGAKERVYEALIEEKT 556

  Fly   728 KNVIYLKLSAKCVEAMALQADTELEVDIQFQLNRMPYCEWHNAVDKITDFRLIFPATELEPSIPW 792
            |:.|:|::..:|.:.:.|.||.||:|::||||||:|.||.|.|:|::.|..::||...|.|:|||
Zfish   557 KDYIFLRVCKECCDELGLVADQELQVELQFQLNRLPLCEMHYALDRVRDNSILFPDISLTPTIPW 621

  Fly   793 TPKKQWADSCEPKLNAKQREAVNAITTALSIKLPPILLIGPFGTGKTYTLAQAIKQLLTQPEAKI 857
            :|.:||.:..:|:|||||:||:.||||.|||.|||:|:|||:|||||:|||||:|.:|.|||:::
Zfish   622 SPNRQWDEQLDPRLNAKQKEAILAITTPLSINLPPVLIIGPYGTGKTFTLAQAVKHILKQPESRV 686

  Fly   858 LICTHSNSAADLYIKEYLHPWIEEGLKEATPLRVYYHKRWSATVNGVVQKYCITDGVG-NFLRPT 921
            |||||||||||||||:||||::|.|...|.|||||:..||..||:.:||:||:..|.. .|..||
Zfish   687 LICTHSNSAADLYIKDYLHPYVEAGNPHARPLRVYFRNRWVKTVHPLVQQYCLISGAHFTFQMPT 751

  Fly   922 VEDIMRHRIVVVTLSISMELATLGLPKGLFTHIFLDEAAQAMECEAIMPLALANDSTRIVLAGDH 986
            .:|:.|||:||||||.|..|..|.|..|:||||.|||||||||||.|||||||..|||:||||||
Zfish   752 RQDVERHRVVVVTLSTSQYLCQLDLEPGIFTHILLDEAAQAMECETIMPLALAVKSTRVVLAGDH 816

  Fly   987 MQMSPELFSAFAKERKLHISLLERLYDHYPSNFPCKILLCENYRAHEAIIRFTSELFYEQKLVAS 1051
            ||:||.::|.||:||.||:|||:|||:||||.:||:||||||||:|||||.:||:||||.||:||
Zfish   817 MQLSPFVYSEFARERNLHVSLLDRLYEHYPSEYPCRILLCENYRSHEAIINYTSDLFYEGKLMAS 881

  Fly  1052 GKQPRHDRFYPLTFFTTRGEDVQDKNSTAFYNNAEVYEVVERVSELRKRWPSAWGKLNDTSIGIM 1116
            ||||.|..||||||||.||||||:|||||:||||||:|:||||.|:||:||.:||||.:.|||::
Zfish   882 GKQPPHKDFYPLTFFTARGEDVQEKNSTAYYNNAEVFEIVERVEEMRKKWPVSWGKLEEGSIGVV 946

  Fly  1117 TPYSDQVFRIRSELRKRRMGGISVERVLNVQGKQFRAVFLSTVRTRRTCM-PQGSAPGSASTTSI 1180
            :||:|||||||:||||:||..:||||||||||||||.:||||||||.||. .|.:..........
Zfish   947 SPYADQVFRIRAELRKKRMSEVSVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTAIKRKEQLVED 1011

  Fly  1181 GDADADYGFLSNSKLLNTAITRAQSLVAVVGDPVALCSIGRCRKVWERFIEICDEHKSLFGLTWS 1245
            ...|.|||||||.||||||||||||||||||||:||||:|||||.||.||.||.|:.||.|:|:.
Zfish  1012 STEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSVGRCRKFWETFISICHENHSLHGITFE 1076

  Fly  1246 NLRSQLDGVELKRGYVLNPLAPEFVPRALQPEAYLREQAALYLNGPQHGHG--GHGPPGPPAHFA 1308
            .::.||:.:|||:.||||||||||:||||:.:           :.||.|.|  .|.||......|
Zfish  1077 QIKIQLEALELKKTYVLNPLAPEFIPRALRSQ-----------HPPQQGPGKHQHSPPKAKGQLA 1130

  Fly  1309 NAAGMLGPGPAAAAHQMNQMAAAMAANQQQLTAHMYSTHMAMMAAAVGGKSGN-----GPG---- 1364
            |..   .|.|.....|.|  ||.:..|..|    .::...|  .|...|||.:     .||    
Zfish  1131 NHT---EPFPPEGFVQPN--AAVLMGNPIQ----AFTPPGA--GAPASGKSPSPVQRLDPGASIL 1184

  Fly  1365 --PGTGGG----PGPGPGP--------------------------------------PPHYGGG- 1384
              |...||    |.|.|.|                                      |..||.. 
Zfish  1185 YVPAVYGGNMVMPMPLPVPQLLPWAGYQSRFPMDPRIMSHQAAMYNLNLRPAASRTSPVLYGFSH 1249

  Fly  1385 -------------------GGGGGHMGMRGPPPPAPHLRGMPPGGPPP-------------TQQP 1417
                               ..|.|.|.:.|   .|.|.|.:.|....|             .:.|
Zfish  1250 ASPLGLNQQQNTEKELLQEPSGNGKMDING---KAEHCRLLTPERKAPELKEKQGDLESVQNKSP 1311

  Fly  1418 GGAGGGGGP-----------------PPPYGQYPAMQHWR---PPQQGQNQGP-GQQPPQNPNAS 1461
            ......|.|                 .||:..:|: .|..   |.|.|.::.| ..|.|.:|.||
Zfish  1312 EPQSNMGFPANRLIRKDPQRALNFHMAPPHPAFPS-HHGTSQFPQQYGLSRPPLRMQTPMHPQAS 1375

  Fly  1462 LWGPPPQTNPWSVLPPSKQPQQPQPP-----PVSAPGRGPGPLPPPLNANPSLPLRG--GSVPPP 1519
            .:            |||.....|..|     ||...|.      .|:.|..|..|:|  ..:|  
Zfish  1376 SF------------PPSFYSGPPMGPRGLQSPVLEGGE------DPMGAGMSEDLKGVVRGLP-- 1420

  Fly  1520 PPNASTAAHLLRNPSELGYLAKKSLYN------HGQ------ALPHHQ------------LYGPG 1560
                   |.:.:.|..|....::||.:      .||      ||.|.|            ....|
Zfish  1421 -------AQMHQQPLRLNSFGEESLDSLLGDTLDGQASSGMDALQHQQQARVGQWGEHTPFLPAG 1478

  Fly  1561 PGPPPPPSQQQPQAPPMGMQRGSSVPNGPMSPMENGPPPPPYLRHNGSGYNPGAPPPPPQQQPQP 1625
            ..|.|.|.|....|.|                   |...||.:...|.|..|.            
Zfish  1479 VAPFPLPQQLAHLAQP-------------------GLRIPPQILRAGWGLGPA------------ 1512

  Fly  1626 PPNPFMYAGKQPSPSSMRFGPMTHELLPPNVSIYDMAFNPKDEQYKWYVKLLETVGQDGANKFAE 1690
                   |.::|.|:..|:..:..|:|            |:|:||:         .:|.|.    
Zfish  1513 -------ADEEPRPTMPRYPGLLREML------------PQDQQYE---------QRDPAE---- 1545

  Fly  1691 MLRQVMATMQQQQQQHKPPQP-----PMANNPMLNNPHVQRPQYP--MMYPQGQQQQQQQPPQQS 1748
             :....:.:.|.:||.:|..|     |.::.|..|.|...:|.||  ...|.....|...||..|
Zfish  1546 -MPPPQSRLLQYRQQIQPRSPGDLPSPSSSAPNHNFPAPAQPSYPDTSREPPVGFSQAPFPPDHS 1609

  Fly  1749 VDASP-PLENFNQQI------DLVFNSIMNGANDVAQPILRDVLGMVAGTGNAPGPPLSNGLNGV 1806
              |.| |::...|:.      .::.:.:..|...:||             ...|||         
Zfish  1610 --AGPLPVKYLLQEAHWPHPGHMLGHGLPFGLQAMAQ-------------RQDPGP--------- 1650

  Fly  1807 DLQQQQQQQQ-QQQQSRLFAMMQQQQQQQQQQQAKPPLGPG-PLYPNHLGGPGLHQAP----PNG 1865
             ||.|||:|| |..||.|.::.:.:           |.||| |||...:........|    |  
Zfish  1651 -LQHQQQKQQLQAPQSSLHSLDEYE-----------PRGPGRPLYQRRISSSSPQPYPDSLEP-- 1701

  Fly  1866 GGNLSGVGNTNFMGNAGNALLNDKPYNNVGMHNNVGLNIGGAG-VAGHNSNNNNGMLTNGNNSVP 1929
                                 .|:|..:. .:.:..|.:||.| |.|               ..|
Zfish  1702 ---------------------QDQPVPSY-RYPSADLWLGGPGPVPG---------------PAP 1729

  Fly  1930 LYRRQAHTGNGIGGGNGDYNNMHGMDAGANLIEALFQANNSVVDHSVKSSDHMHGLLYNNFNGLK 1994
            ::....:..:.||                        .:..::.....|.:.|            
Zfish  1730 IHNIPCNGASHIG------------------------PHREILVSKAMSEEQM------------ 1758

  Fly  1995 GGGHELDLFQAMAPSVPHSEAA---NHHQQSSGSSATTYAAVL-SQGPQAVVGGGVGTGPS---- 2051
                :.:..|...|..||..:|   .||.|        :..:| |:......|||..|.|:    
Zfish  1759 ----KAECLQPPPPPPPHPASAASLQHHGQ--------FPPLLPSKQTPPDPGGGGNTSPAGHPK 1811

  Fly  2052 -PGQSQAQAGVAGSGTGGKVAPAVGRNDLLEKDPFAAIREL----GQATTGFYNYFQ 2103
             |..|.|.|..|..    |..|.:........||.:.::||    ..::.|:|.||:
Zfish  1812 PPTMSYASALRAPP----KPRPMLPEQSKKNSDPISLLQELSIGSSNSSNGYYTYFK 1864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HelzNP_001261848.1 zf-CCCH 329..353 CDD:279036 13/23 (57%)
TIGR00376 657..1236 CDD:273041 359/583 (62%)
AAA 810..>886 CDD:99707 53/75 (71%)
AAA_12 1003..1213 CDD:289832 150/210 (71%)
helzXP_021325743.1 zf-CCCH 171..195 CDD:279036 13/23 (57%)
AAA_11 635..826 CDD:331082 125/190 (66%)
AAA_12 833..1044 CDD:315700 150/210 (71%)
Med15 <1108..>1396 CDD:312941 64/325 (20%)
Atrophin-1 <1473..1835 CDD:331285 107/552 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170592808
Domainoid 1 1.000 311 1.000 Domainoid score I1285
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1056 1.000 Inparanoid score I251
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D286011at2759
OrthoFinder 1 1.000 - - FOG0008398
OrthoInspector 1 1.000 - - oto40261
orthoMCL 1 0.900 - - OOG6_107750
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X6388
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.800

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