DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Helz and Helz2

DIOPT Version :9

Sequence 1:	NP_001261848.1	Gene:	Helz / 39613	FlyBaseID:	FBgn0036451	Length:	2103	Species:	Drosophila melanogaster
Sequence 2:	NP_001292205.1	Gene:	Helz2 / 296474	RGDID:	1306056	Length:	2944	Species:	Rattus norvegicus

Alignment Length:	1010	Identity:	331/1010 - (32%)
Similarity:	507/1010 - (50%)	Gaps:	128/1010 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 DGSGSDQGDQAAPSTTCSYCTITFQTRNELRQHCQTEAHQKVIMSDEGRDWKWRPPPRGYTLDTY 329
            |...:..|...|....|..|.:|..::.....||.:..|.:::..|:....|.|.||.|  |..:
  Rat   272 DKQKASHGQPPAVKLYCHACLVTCSSQEAFENHCSSLEHAQMVAFDQVVPRKHRAPPMG--LSKF 334

  Fly   330 SLCETFSEAHICHYGAQCVEAHGQDELNEWKERFEYRRMRMQKACEKELYGKSYTEQVLDRWIQA 394
            .||   ....:|.||..|::||.:.||.||.:|.:...:|.|.|.:..|.  .|..::|..:.::
  Rat   335 ELC---PRPDLCEYGEVCIKAHSKQELQEWVQRAQDMELREQAAWQDGLV--PYQARLLAEYRRS 394

  Fly   395 TAPERVMCERVPDMEARCEQQLVTSISSKTSKREWLFQLETKKPLKAVALLQDAHRNHFALKSIK 459
            :....||.|.|..:...|:|.||.....|. :.:|:|.:.::.||..||||:......|:|.:
  Rat   395 SKEVLVMAETVHGVSVTCQQPLVHQAQEKI-QHKWVFTIHSEDPLLHVALLKQEPGAAFSLVA-- 456

  Fly   460 MCKPTESSMELKSDQEWLAGSSSQSETSNEDSATLIHEITVEFHTEIYGTFRQAICFDVGQEPLL 524
               |.....:|.:..:.....:|.::          .::.|......:|:|.|.:.||.|:.|:|
  Rat   457 ---PHLPPHQLYAQGKHFCVPNSPAQ----------FQVGVLVQAASFGSFEQWVVFDFGRRPVL 508

  Fly   525 VRHLCVDV------------LPVNDAEKIEEIKRDIINSSATRWDVANTQLTRFETTIGTHLKTE 577
            ::.|.:.:            .|.:..|:             ..|...|           .|:..|
  Rat   509 LQKLKLQLGQTHSLGLNGKPAPSHPQER-------------ECWHTGN-----------RHVVLE 549

  Fly   578 AYLSDLEHERE-LLERYPCPRAATFTLTQSTIVEKRLTQNNYRSRIHELLSVEEIARYEQIARYN 641
            .   |...|:| |:.:|..|..| ...:.:.:|...:::.|||.|:|:.|..||.|:.:.:|:..
  Rat   550 V---DWTPEQEALMAKYKLPSLA-LEFSHNVVVWGPISRTNYRQRMHKFLYEEEAAQQQLVAKLA 610

  Fly   642 VRTRLTVASNYILTPA-GMATSTAKYSLAGELFALMRLGKDISEDTSPGRLILSNCSSVYISKPE 705
            ::.:::: ...:.||| ||.     ::..|.|:|.:.....:..||..|.|:....|:..::...
  Rat   611 MKGQVSL-KTALETPALGML-----FAPPGALYAEVPFPSSLLPDTDQGFLMSRAVSTALVAPAP 669

  Fly   706 DPDSKADPTKRAVYEALIEDK--GKNVIYLKLSAKCVEAMALQADTELEVDIQFQLNRMPYCEWH 768
            .||||       ||:..:|.:  .::.::|.|.|:|..|:.|||.....:::|||::.:.:..||
  Rat   670 APDSK-------VYQVRLEARASSEHALWLLLPARCCMALGLQAQDSPVLEVQFQIDPLIFRFWH 727

  Fly   769 NAVDKITDFRLI---FPATELEPSIPW-TPKKQWADSCEPKL--NAKQREAVNAITTAL---SIK 824
            .|||.:.:..|:   .||..|..  || ||         |..  |.||:.||..|....   |..
  Rat   728 RAVDALPEVCLVVPDLPACTLPH--PWPTP---------PSFRGNHKQKLAVGLIAGRRPEGSKH 781

  Fly   825 LPPILLIGPFGTGKTYTLAQAIKQLLTQPEAKILICTHSNSAADLYIKEYLHPWIEEGLKEATPL 889
            :||:|:.||||||||||||.|..:::.||..|:|||||:|||||:|::||.|.::..|.:||.||
  Rat   782 IPPLLIYGPFGTGKTYTLAMAALEVVQQPHTKVLICTHTNSAADIYVREYFHGYVNSGHQEAAPL 846

  Fly   890 RVYYHKRWSATVNGVVQKY-CITDGVGNFLRPTVEDIMRHRIVVVTLSISMELATLGLPKGLFTH 953
            ||.|..|.....:....:| |:|:....|..||..:::|||:||.|.|.:.||.   :|.|.|:|
  Rat   847 RVMYADRPPRQTDSTTLQYCCLTEDRQAFRPPTFPELLRHRLVVTTTSQARELQ---VPAGFFSH 908

  Fly   954 IFLDEAAQAMECEAIMPLALANDSTRIVLAGDHMQMSPELFSAFAKERKLHISLLERLYDHYPSN 1018
            ||:|||||.:||||::||:.|...||:||||||||::|.|||....:...|: ||.||:.:|...
  Rat   909 IFIDEAAQMLECEALIPLSYALTLTRVVLAGDHMQVTPRLFSVPRDKAAGHM-LLHRLFLYYQQE 972

  Fly  1019 F-----PCKILLCENYRAHEAIIRFTSELFYEQK---LVASGKQPRHDRFYPLTFFTTRGEDVQD 1075
            .     ..:|:..||||:..|||.|.|..||..|   :.||||.|||.:.|||.|....|...||
  Rat   973 VHKIAQHSRIVFHENYRSTAAIINFVSRHFYVAKGNPIQASGKVPRHPQHYPLMFCHVAGSPEQD 1037

  Fly  1076 KNSTAFYNNAEVYEVVERVSELRKRWPSAWGKLNDTSIGIMTPYSDQVFRIRSELRKRRMGGISV 1140
            .:.|::.|:|||.:|||:|.|:...||..||......|..:: :..||..:|.|||:|.:|.:||
  Rat  1038 MSRTSWLNSAEVTQVVEKVQEIYNTWPHCWGPREQRHICAVS-HGAQVSALRQELRRRNLGEVSV 1101

  Fly  1141 ERVLNVQGKQFRAVFLSTVRTRRTCMPQGSAPGSASTTSIGDADADYGFLSNSKLLNTAITRAQS 1205
            .....:.|::||.|.||:|..|.:.:..| ||.|.             |.:..::|||.:|||||
  Rat  1102 GSFEILPGREFRVVVLSSVHNRNSLLSPG-APTSE-------------FFTEPRVLNTVMTRAQS 1152

  Fly  1206 LVAVVGDPVALCSIGRCRKVWERFIEICDEHKSLF 1240
            .:..|||.|||||.|.|||:|:.||..|.||.|:|
  Rat  1153 QLVAVGDAVALCSSGACRKLWKNFIRECIEHHSIF 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Helz	NP_001261848.1	zf-CCCH	329..353	CDD:279036	8/23 (35%)
		TIGR00376	657..1236	CDD:273041	234/599 (39%)
		AAA	810..>886	CDD:99707	39/78 (50%)
		AAA_12	1003..1213	CDD:289832	81/217 (37%)
Helz2	NP_001292205.1	DEAD-like_helicase_N	759..989	CDD:421690	105/233 (45%)
		AAA_12	961..1160	CDD:404073	80/213 (38%)
		RNB	1565..1923	CDD:214935
		DEXXc_HELZ2-C	2446..2721	CDD:350798
		AAA_12	2701..2906	CDD:404073
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910