Protein Alignment Helz and Helz

DIOPT Version :10

• Sequence 1: NP_648725.2
• Gene: Helz / 39613
• FlyBaseID: FBgn0036451
• Length: 2103
• Species: Drosophila melanogaster
• Sequence 2: XP_008766536.1
• Gene: Helz / 287773
• RGDID: 1307049
• Length: 1981
• Species: Rattus norvegicus
• Alignment Length: 2078
• Identity: 748/2078 - (35%)
• Similarity: 1050/2078 - (50%)
• Gaps: 416/2078 - (20%)

  Fly   248 LLAAMKLTAGKHQPGSGDGSGSDQGDQAAPSTTCSYC---TITFQTR---NELRQHCQTEAHQKV 306
            :|..|:| .||.||.|...:.|..|:......|....   |:..:|.   :.....|..|.
  Rat    98 VLCCMQL-KGKLQPVSSILAQSLSGESLNGMVTKDLTRLKTLLAETETATSNAPSGCHVED---- 157

  Fly   307 IMSDEG--RDWKWRPPPRGYT-LDTYSLCETFSEAHICHYGAQCVEAHGQDELNEWKERFEYRRM 368
              .|||  ..|.:||||||.| .:.|:||:.|.|..||.|||||..||.|:||.||::|:..|.:
  Rat   158 --LDEGSCNGWHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLI 220

  Fly   369 RMQKACEKELYGKSYTEQVLDRWIQATAPERVMCERVPDMEARCEQQLVTSISSKTSKREWLFQL 433
            ::::..|.:....||.|.::::|:.:.:||:|:.|.:..::......|..::::|.|.:.|.|.|
  Rat   221 KLKQQSENKQLSGSYMETLIEKWMSSLSPEKVLSECLEGVQVEHSPDLSVTVNTKKSHQTWTFAL 285

  Fly   434 ETKKP---LKAVALLQDAHRNHFALKSIKMCKPT-ESSMELKSD-QEWLAGSSSQSETSNEDSAT 493
             |.||   |..||||.||||.||::.:|.....| :.|.|:..: |||:.|..:|:...:
  Rat   286 -TCKPARMLCRVALLYDAHRPHFSIIAISAGDSTAQVSQEVPENCQEWIGGEMAQNGLDH----- 344

  Fly   494 LIHEITVEFHTEIYGTFRQAICFDVGQEPLLVRHLCVDVLPVNDAEKIEEIKRDIINSSATRWDV 558
            .::::.:.|:|||:|||||.|.||.|.||:|::.:.:|.....|.|.:...|:.:: ::|.||:.
  Rat   345 YVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLV-TTARRWEP 408

  Fly   559 ANTQLTRFETTIGTHLKTEAYLSDLEHERELLERYPCPRAATFTLTQSTIVEKRLTQNNYRSRIH 623
            ::..:..||....|           :.|:.||.||..|.:|....||| :::|.||:.||:||:|
  Rat   409 SSKTIVDFEPNETT-----------DWEKSLLIRYQIPLSADQLFTQS-VLDKSLTKTNYQSRLH 461

  Fly   624 ELLSVEEIARYEQI-----------------ARYNVRTRLTVASNYILTPAGMATSTAKYSLAGE 671
            :||.:||||:|:::                 |::|::.:|.:.::::||.   .:..|||:..|:
  Rat   462 DLLYIEEIAQYKEVSRLNGIEPVKVPICVHCAKFNLKVQLQILASFMLTG---VSGGAKYAQNGQ 523

  Fly   672 LFALMRLGKDISEDTSPGRLILSNCSSVY-ISKPEDPDSKADPTKRAVYEALIEDKGKNVIYLKL 735
            ||...:|.:.:||||..|||:::..::|| :..|::...::..||..||||.||:|.|:.::|::
  Rat   524 LFGRFKLTETLSEDTLAGRLVMTRVNAVYLLPVPKEKLVQSQGTKEKVYEATIEEKTKDYVFLRI 588

  Fly   736 SAKCVEAMALQADTELEVDIQFQLNRMPYCEWHNAVDKITDFRLIFPATELEPSIPWTPKKQWAD 800
            |.:|.|.::|:.|.:.:|::||||||:|.||.|.|:|:|.|..::||...:.|:|||:|.:||.:
  Rat   589 SRECCEELSLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQWDE 653

  Fly   801 SCEPKLNAKQREAVNAITTALSIKLPPILLIGPFGTGKTYTLAQAIKQLLTQPE-AKILICTHSN 864
            ..:|:|||||:|||.||||.|.|:|||:|:|||:|||||:|||||:|.:|.|.| ::||||||||
  Rat   654 QLDPRLNAKQKEAVLAITTPLCIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETSRILICTHSN 718

  Fly   865 SAADLYIKEYLHPWIEEGLKEATPLRVYYHKRWSATVNGVVQKYC-ITDGVGNFLRPTVEDIMRH 928
            ||||||||:||||::|.|..:|.|||||:..||..||:.||.:|| |:.....|..|..|||::|
  Rat   719 SAADLYIKDYLHPYVEAGNAQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKH 783

  Fly   929 RIVVVTLSISMELATLGLPKGLFTHIFLDEAAQAMECEAIMPLALANDSTRIVLAGDHMQMSPEL 993
            |:|||||:.|..|..|.|..|.||||.|||||||||||.|||||||..:|||||||||||:||.:
  Rat   784 RVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALATKNTRIVLAGDHMQLSPFV 848

  Fly   994 FSAFAKERKLHISLLERLYDHYPSNFPCKILLCENYRAHEAIIRFTSELFYEQKLVASGKQPRHD 1058
            :|.||:||.||:|||:|||:|||:.|||:||||||||:|||||.:|||||||.||:||||||.|.
  Rat   849 YSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHK 913

  Fly  1059 RFYPLTFFTTRGEDVQDKNSTAFYNNAEVYEVVERVSELRKRWPSAWGKLNDTSIGIMTPYSDQV 1123
            .||||||||.||||||:||||||||||||:||||||.|||::||.|||||:|.|||::|||:|||
  Rat   914 DFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQV 978

  Fly  1124 FRIRSELRKRRMGGISVERVLNVQGKQFRAVFLSTVRTRRTCMPQGSAPGSASTTSIGDA--DAD 1186
            ||||:||||:|:..::|||||||||||||.:||||||||.||..: ..|.......:.|:  |.|
  Rat   979 FRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHK-QTPIKKKEQLLEDSTEDLD 1042

  Fly  1187 YGFLSNSKLLNTAITRAQSLVAVVGDPVALCSIGRCRKVWERFIEICDEHKSLFGLTWSNLRSQL 1251
            ||||||.|||||||||||||||||||||||||||||||.|||||.:|.|:.||.|:|:..:::||
  Rat  1043 YGFLSNYKLLNTAITRAQSLVAVVGDPVALCSIGRCRKFWERFIALCHENHSLHGITFEQIKAQL 1107

  Fly  1252 DGVELKRGYVLNPLAPEFVPRALQPEAYLREQAALYLNGPQH-GHGGHGPPGPPA---------- 1305
            :.:|||:.||||||||||:|||.:               .|| |:.......||.
  Rat  1108 EALELKKTYVLNPLAPEFIPRAFR---------------LQHSGNSSRQQQSPPKVKSLHHPQND 1157

  Fly  1306 HFANAAGMLGPGPAAAAHQMNQMAAAMAANQQQLTAHMYSTHMAMMAAAVGGKSGNGPGPGTGGG 1370
            ||.| .|::.|.|:....  |.:.|             |:....:           ||.|..|..
  Rat  1158 HFQN-DGIVQPNPSVLIG--NPIRA-------------YTPPPPL-----------GPHPNLGKS 1195

  Fly  1371 PGPGPGPPPHYGGG-----GGGGGHMGMRGPPPPAP----------------------------H 1402
            |.|.....||.|..     ...||::.| ..|.|.|                            |
  Rat  1196 PSPVQRIDPHTGTSILYVPAVYGGNVVM-SVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLH 1259

  Fly  1403 LRGMPPGGPPPTQQPGGAGGGGGPPPPYGQYPAMQHWRPPQQGQNQGPGQQPPQNPNASLWGPPP 1467
            ..|.  |.|.|      .|.|..||...|| |..||....||.||:. |:....||.       |
  Rat  1260 THGR--GSPIP------YGLGHHPPVNLGQ-PQNQHAEKDQQEQNRN-GKTDTNNPG-------P 1307

  Fly  1468 QTNPWSVLPPSKQPQQPQP------PPVSAPGRGPG------PLPPPLNANPSLPLRGGSVPPPP 1520
            :.|  .:..|.|:|.:|:.      |...:|...||      ..|...|.||    |..::|.|.
  Rat  1308 EIN--KIRTPEKKPTEPKQIDLESNPQNRSPESRPGVVYSNTKFPRKDNLNP----RHINLPLPA 1366

  Fly  1521 PNASTAAHLLRNPSELGYLAKKSLYNHGQALPHHQLYGPGPGPPPPPSQQQPQAPPMGMQRGSSV 1585
            |:...|.     ||           .|...||  ||    |.||.|.|||.    .:..|:.:::
  Rat  1367 PHTQYAI-----PS-----------RHFHPLP--QL----PRPPFPISQQH----TLLNQQQNNL 1405

  Fly  1586 PNGP--MSPMENGPPPPPYLRHNGSGYNPG--APPP---------PPQQQPQPPP--NPFMYAG- 1634
            |..|  |:|..|...|.|    |.....|.  ||.|         .|.|.|||.|  :|...||
  Rat  1406 PEQPNQMTPQPNQVAPQP----NQMAPQPNQMAPQPNQVVQQQNQAPPQAPQPAPQLSPAFQAGP 1466

  Fly  1635 -----------KQPSPSSMRFGPMTHELLPPNVS--------------IYDMAFNPKDEQYKWYV 1674
                       :..||::...||  .:.:||.:|              |.....|...::....:
  Rat  1467 TNAFFNNAVAHRPQSPAAEAVGP--EQQVPPGLSDGHSPLRAITQPGPILASPLNNFVDESSPGL 1529

  Fly  1675 KLLETVGQDGANKFAEMLRQVMATMQQQQQQH---KPPQPPMANNPMLNNPHVQR-PQYPMMYPQ 1735
            .:.|.:.:...:...|.|||..|.:||..:.|   .....|.:::   ::||:.. ||.|:...|
  Rat  1530 PIEEALDRVHGSVALETLRQQQARLQQWSEHHAYLSQGGIPYSHH---HHPHLAHLPQTPISLHQ 1591

  Fly  1736 GQQQQQQQPPQQSVDASPPLE-------NFNQQIDLVFNSIMNGANDVAQPILRDVLGMVAG-TG 1792
                             ||:.       ..:.:.:..|:..        |.:||::.....| ||
  Rat  1592 -----------------PPVRAEWKVAGRADDETETTFSRF--------QDLLRELSHRDQGDTG 1631

  Fly  1793 N-APGPPLSNGLNGVDLQQQQQQQQ----------QQQQSRLFAMMQQQQQQQQQ------QQAK 1840
            . |..||..:.|    ||.:|.|.:          ....|..||......:..:.      .|..
  Rat  1632 ELAEMPPPQSRL----LQYRQVQPRSPPAVPSPPSSTDHSSHFANFNDNSRDIEVANSPAFPQRL 1692

  Fly  1841 PPLGPGPLY---PNHLGGPGLHQAPPNGGGNLSGVGNTNFMGNA---GNALLNDKPYNNVGMH-- 1897
            ||...||.|   ..||..|.|....|.|..|.:.:...:.:|..   |...|..:|..|..:|
  Rat  1693 PPQLFGPPYSLQSEHLAPPPLKYLAPEGAWNFANLQQNHLIGPGFPYGLPPLPPRPPQNPFIHIQ 1757

  Fly  1898 ---NNVGLN----IGGAGVAGHNSNNNNGMLTNGNNSVPLYRRQAHTG-------------NGIG 1942
               :.||..    :....|:..:..:.......|... |||:|:..:|             :.:.
  Rat  1758 NHQHAVGQEPFHPLPSRAVSSSSLPSLEEYEPRGPGR-PLYQRRISSGAAQPCVEEASTPQDSLA 1821

  Fly  1943 GGN--GDYNNMHGM-----DAGANLI-EALFQ---ANNS----------VVDHSVKSSDHM---- 1982
            .|.  .|::|..|.     ::.||.. .|.:|   .|.|          |...:||..:..
  Rat  1822 QGKEPQDHSNPPGFGFPAPESWANTTSSAPYQNIPCNGSSRTSQPRELIVPPKTVKPPEDQLKPD 1886

  Fly  1983 HGLLYNNFNGLKGGGHELDLFQAMAPSVPHSEAANHHQQSS--GSS-ATTYAAVLSQGPQAVVGG 2044
            .|.:.::||  ......|..|..:.|:...:|:||...|.|  ||. |.:||:.|...|:
  Rat  1887 SGEVSSSFN--YSVLQHLGQFPPLMPNKQIAESANSSSQQSPAGSKPAMSYASALRAPPK----- 1944

  Fly  2045 GVGTGPSPGQSQAQAGVAGSGTGGKVAPAVGRNDLLEKDPFAAIREL----GQATTGFYNYFQ 2103
                 |.|...||:.|                     .||.:..:||    ...:.|||:||:
  Rat  1945 -----PRPPPEQAKKG---------------------SDPLSLFQELSLGSSPGSNGFYSYFK 1981

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Helz	NP_648725.2	zf-CCCH	329..353	CDD:459885	14/23 (61%)
		DEXXQc_HELZ	805..1030	CDD:350835	149/226 (66%)
		DNA2	<925..1236	CDD:440729	227/312 (73%)
Helz	XP_008766536.1	zf-CCCH	181..205	CDD:459885	14/23 (61%)
		DEXXQc_HELZ	658..885	CDD:350835	151/228 (66%)
		DNA2	<783..1092	CDD:440729	225/310 (73%)
		Atrophin-1	<1261..>1536	CDD:460830	83/327 (25%)
		PRK10263	<1336..>1430	CDD:236669	27/105 (26%)