Protein Alignment Helz and Helz2

DIOPT Version :10

• Sequence 1: NP_648725.2
• Gene: Helz / 39613
• FlyBaseID: FBgn0036451
• Length: 2103
• Species: Drosophila melanogaster
• Sequence 2: XP_006500664.1
• Gene: Helz2 / 229003
• MGIID: 2385169
• Length: 2970
• Species: Mus musculus
• Alignment Length: 1070
• Identity: 339/1070 - (31%)
• Similarity: 524/1070 - (48%)
• Gaps: 142/1070 - (13%)

  Fly   268 GSDQGD------------QAAPSTT-------CSYCTITFQTRNELRQHCQTEAHQKVIMSDEGR 313
            |..:||            :|:|:..       |..|.:|..::.....||.:..|.:::..|:..
Mouse   257 GLQRGDLLTYPLFGENKWKASPNPNPPVTKLYCHACLVTCNSQEAFENHCSSLEHAQMVAFDQAV 321

  Fly   314 DWKWRPPPRGYTLDTYSLCETFSEAHICHYGAQCVEAHGQDELNEWKERFEYRRMRMQKACEKEL 378
            .||.|.||.|  |..:.||   ....:|.:|..|::||.:.||.||.:|.:...:|.|.|.:..|
Mouse   322 PWKHRAPPMG--LSKFDLC---PRPDLCEHGEVCIKAHSKQELQEWVQRAQDMELREQAAWQDGL 381

  Fly   379 YGKSYTEQVLDRWIQATAPERVMCERVPDMEARCEQQLVTSISSKTSKREWLFQLETKKPLKAVA 443
            .  .|..::|..:.:::....||.|.:..:...|....|.....|. :.:|:|.:.::.||..||
Mouse   382 V--PYQARLLAEYQRSSKEVSVMAETIRGVSVTCHPPPVHQAQEKI-QHQWVFTIHSEDPLLHVA 443

  Fly   444 LLQDAHRNHFALKSIKMCKPTESSMELKSDQEWLAGSSSQSETSNEDSATLIHEITVEFHTEIYG 508
            ||.......|:|.:     |:....:|.:..:.....||.::          :::.|......:|
Mouse   444 LLNQEPGAAFSLVA-----PSLPPHQLYAQGKHFCVQSSPAQ----------YKVGVLVQAVAFG 493

  Fly   509 TFRQAICFDVGQEPLLVRHLCVDVLPVNDAEKIEEIKRDIINSSATRWDVANTQLTRFET--TIG 571
            :|.|.:.||.|:.|:|::.|              :::....:|.......|.:.....|.  |..
Mouse   494 SFEQWVVFDFGRRPVLLQKL--------------KLQLGQTHSQGLNGKPAPSHPQELECWHTGN 544

  Fly   572 THLKTEAYLSDLEHERE-LLERYPCPRAATFTLTQSTIVEK--RLTQNNYRSRIHELLSVEEIAR 633
            .|:..|.   |...|:| |:.:|..|..|   |..:.||..  .::::|||.|:|:.|..||.|:
Mouse   545 RHVVLEV---DWTPEQEALMAKYKLPSLA---LEFNQIVPDWGPISRSNYRQRMHKFLYEEEAAQ 603

  Fly   634 YEQIARYNVRTRLTVASNYILTPA-GMATSTAKYSLAGELFALMRLGKDISEDTSPGRLILSNCS 697
            .:.:|:..::.:::: ...:.||| ||.     ::..|.|:|.:.....:..||..|.|:....|
Mouse   604 QQLVAKLAMKGQVSL-KTALETPALGML-----FAPPGALYAKVPFHSSLLPDTDQGFLLSRAVS 662

  Fly   698 SVYISKPEDPDSKADPTKRAVYEALIEDKGK--NVIYLKLSAKCVEAMALQADTELEVDIQFQLN 760
            :..::....|:|       .||:..:|.:..  :.::|.|.|:|..|:.|||.....:::|||::
Mouse   663 TALVAPVPAPNS-------TVYQVRLEARASSDHALWLLLPARCCMALGLQAQDSPILEVQFQID 720

  Fly   761 RMPYCEWHNAVDKITDFRLI---FPATELEPSIPW-TPKKQWADSCEPKL--NAKQREAVNAITT 819
            .|.:..||.|||.:.:..|:   .||..|..  || ||         |..  |.||:.||..|..
Mouse   721 PMTFRFWHQAVDALLEEHLVVPDLPACTLPH--PWPTP---------PSFRGNHKQKLAVGLIAG 774

  Fly   820 AL---SIKLPPILLIGPFGTGKTYTLAQAIKQLLTQPEAKILICTHSNSAADLYIKEYLHPWIEE 881
            ..   :..:||:|:.||||||||||||.|..:::.||..|:|||||:|||||:||:||.|.::..
Mouse   775 RRPEGTKHIPPLLIYGPFGTGKTYTLAMAALEVVQQPHTKVLICTHTNSAADIYIREYFHDYVSS 839

  Fly   882 GLKEATPLRVYYHKRWSATVNGVVQKY-CITDGVGNFLRPTVEDIMRHRIVVVTLSISMELATLG 945
            |..|||||||.|..|.....:....:| |:|:....|..||..:::.||:||.|.|.:.||.
Mouse   840 GHPEATPLRVMYADRPPRQTDPTTLQYCCLTEDRQAFRPPTGPELVHHRLVVTTTSQARELQ--- 901

  Fly   946 LPKGLFTHIFLDEAAQAMECEAIMPLALANDSTRIVLAGDHMQMSPELFSAFAKERKLHISLLER 1010
            :|.|.|:|||:|||||.:||||::||:.|...||:||||||||::|.|||. .:::....:||.|
Mouse   902 VPAGFFSHIFIDEAAQMLECEALIPLSYALSLTRVVLAGDHMQVTPRLFSV-PRDKSARHTLLHR 965

  Fly  1011 LYDHYPSNF-----PCKILLCENYRAHEAIIRFTSELFYEQK---LVASGKQPRHDRFYPLTFFT 1067
            |:.:|....     ..:|:..||||:..|||.|.|..||..|   :.||||.|||.:.|||.|..
Mouse   966 LFLYYQQEAHKIAQQSRIIFHENYRSTAAIINFVSHHFYLAKGNPIQASGKVPRHPQHYPLMFCH 1030

  Fly  1068 TRGEDVQDKNSTAFYNNAEVYEVVERVSELRKRWPSAWGKLNDTSIGIMTPYSDQVFRIRSELRK 1132
            ..|...||.:.|::.|:|||.:|||:|.|:...||..||......|..:: :..||..:|.|||:
Mouse  1031 VAGSPEQDMSMTSWLNSAEVTQVVEKVREIYNTWPHCWGPREQRHICAVS-HGAQVSALRQELRR 1094

  Fly  1133 RRMGGISVERVLNVQGKQFRAVFLSTVRTRRTCMPQGSAPGSASTTSIGDADADYGFLSNSKLLN 1197
            |.:|.:||.....:.|::||.|.||:|..|.:.:..| ||.|.             |.:..::||
Mouse  1095 RNLGEVSVGSFEILPGREFRVVVLSSVHNRNSLLSPG-APTSE-------------FFTEPRVLN 1145

  Fly  1198 TAITRAQSLVAVVGDPVALCSIGRCRKVWERFIEICDEHKSLFGLTWSNLRSQLDGVELKRGYVL 1262
            |.:|||||.:..|||.|||||.|.||.:|..||..|.||.|.|       ..:|...::::|...
Mouse  1146 TVMTRAQSQLVAVGDAVALCSSGACRNLWRSFIRECIEHHSAF-------PEELSLEQIEQGVAQ 1203

  Fly  1263 NPLAPEFVPRALQPEAYLREQAALYLNGPQ 1292
            .........:|..||...:..|    .|||
Mouse  1204 RQNWASLTLKARGPETEQKSMA----QGPQ 1229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Helz	NP_648725.2	zf-CCCH	329..353	CDD:459885	7/23 (30%)
		DEXXQc_HELZ	805..1030	CDD:350835	104/235 (44%)
		DNA2	<925..1236	CDD:440729	133/318 (42%)
Helz2	XP_006500664.1	DEAD-like_helicase_N	760..990	CDD:475120	104/233 (45%)
		AAA_12	961..1161	CDD:463780	80/214 (37%)
		RNB	1567..1924	CDD:214935
		DEXXc_HELZ2-C	2448..2724	CDD:350798
		AAA_12	2704..2909	CDD:463780