Protein Alignment Helz and C44H9.4

DIOPT Version :9

• Sequence 1: NP_001261848.1
• Gene: Helz / 39613
• FlyBaseID: FBgn0036451
• Length: 2103
• Species: Drosophila melanogaster
• Sequence 2: NP_506213.2
• Gene: C44H9.4 / 179760
• WormBaseID: WBGene00008099
• Length: 1099
• Species: Caenorhabditis elegans
• Alignment Length: 1234
• Identity: 226/1234 - (18%)
• Similarity: 383/1234 - (31%)
• Gaps: 427/1234 - (34%)

  Fly   193 NKGLKKREQQQQQQQQQQQQNGNGIGSYASSSSSSSTGS--SSTMSSSS----TSLHKTNDLLAA 251
            |....:|:.::::...||...     |:.:|..||.|.|  ||.:.:||    |...|..:..:.
 Worm    27 NNSYYRRDYEEEEDDVQQYHT-----SHIASIKSSQTTSYRSSVVQNSSVYSRTFSEKEQNAFSK 86

  Fly   252 MKLTAGKHQPGSGDGSGSDQGDQAAPSTTC---SYCTITFQTRNELRQHCQTEAHQKVIMSDEGR 313
            ..:     ||               |.|..   ....|..:...||:.:..::|     ::...|
 Worm    87 FYV-----QP---------------PETNSRQKKKTEIESEVEKELKSYKHSDA-----INFAAR 126

  Fly   314 DWKW-----RPPPRGYTLD--TYSLCETFSEAHI--------------CHYGAQCVEAHGQDELN 357
            .:.|     .|.||....|  |||. |....|:.              ||     ...||   |:
 Worm   127 TFSWGPNFNSPKPRQVFRDISTYSY-ERGIRAYFRVLSAEDNKYILIACH-----ANLHG---LH 182

  Fly   358 EWKERF-EYRRMRMQKACEK----------------ELYGKSYTEQVLDRWIQATAP-------- 397
            ....|| |.....:.|..|.                ||..||....:... |:..:|
 Worm   183 RGDLRFVEVNDRTITKGSENYSVIGMLFPGDVVAVTELSKKSNAPSIAPT-IKNVSPHDPCIWEV 246

  Fly   398 -ERVMCER--------------VPDMEARCEQQLVTSISSKTSKREWLFQLETKKPLKA-VALLQ 446
             :.|:.:|              ...:|...|...|..|..|..|.:.::......|.|: |...:
 Worm   247 NKMVVLQRKSIIRVNFAMLNNGAAIVEGHTEAMDVIEIDRKKLKTDMMYYGTAFIPEKSKVKFSE 311

  Fly   447 DAHRNHFALKSIKMCKPTESSMELKSDQEWLAGSSSQSET-SNEDSATLIHEITVE-FHTEIYGT 509
            ..||.|:           |..|.|.|.....:.|.....| |..:..|.:.:|.|: |::.||..
 Worm   312 GFHRQHW-----------EDLMALTSKLPSYSNSLGTIYTHSLCERQTNMFKIGVDAFNSSIYSL 365

  Fly   510 FRQAICFDVGQEPLLVRHLCVDVLPVNDAEKIEEIKRDIINSSAT------RWDVANTQLTRFET 568
            ..:|        .:||...||                 |:.|||.      |:|..|.|:|..
 Worm   366 NTEA--------SVLVAQKCV-----------------IMGSSAAQTVSNGRFDGRNFQMTNI-- 403

  Fly   569 TIGTHLKTEAYLSDLEHERELLERYPCPRAATFTLTQSTIVEKRLTQNNYRSRIHELLSVEEIAR 633
                |.|::                                       |:|      .|::..::
 Worm   404 ----HRKSQ---------------------------------------NFR------FSIDNPSK 419

  Fly   634 YEQIARYNVRTRLTVASNYILTPAGMATSTAKYSLAGELFALMRLGKDISEDTSPGRLILSNCSS 698
            .....|:|...::.:.                             |:..|..||...::|.|
 Worm   420 QPTEGRWNPNQKIEIN-----------------------------GQGESLKTSIETVVLGN--- 452

  Fly   699 VYISKPEDPDSKADPTKRAVYEALIEDKGKNVIYLKLSAKCVEAMALQADTELEVDIQFQLNRMP 763
                           .::::.......|..|           :.:..|..|.:....||......
 Worm   453 ---------------NRKSLEITATIPKNNN-----------KLLNFQTGTWIVSQSQFLETPRL 491

  Fly   764 YCEWHNAVDKITDFRLIFPA------TELEPSIPWTPKKQWADSCEPKLNAKQREAVNAITTALS 822
            .||:...:...::.|.|..|      .....:|.|..:.::.......||..|.:.|:.|.:.
 Worm   492 DCEFLQKMSPSSNGRRIVTALYGGSPINSTGNINWNKQFEFPSKIPIGLNQYQNQYVSMILSG-- 554

  Fly   823 IKLPPILLIGPFGTGKTYTLAQAIKQLLTQ-------PEAKILICTHSNSAADL----------- 869
              :|.||...|||.||:.|:..|..:|..:       .:.::|:...:|:..:|
 Worm   555 --VPLILGNSPFGCGKSMTIVTAAVELQKKYMRSESFNKQQLLVTQSNNAGVNLIEFALKLHKCD 617

  Fly   870 ------YIKEYLHPWIEEGLKEATPLRVYYHK---RWS-------------------ATVNGVVQ 906
                  |:.|.....:.:..|....:.:....   .|:                   |.|....|
 Worm   618 HIRFLRYVSESNWNSLPDSSKTELDMPILMEDEFFEWATNTEIQKENGENLTREMKKAIVEQSTQ 682

  Fly   907 KY-CITDGVGNFLRPTVEDIMRHR---------------------IVVVTLSISMELATLGLPKG 949
            || |....||...| ..|:|::::                     |:|.|......|....:.:.
 Worm   683 KYHCKGILVGEAKR-IYENILKNQREHKPSQAILKEAFFALYAPDIIVSTADSIHNLLENNVLRD 746

  Fly   950 LFTHIFLDEAAQAMECEAIMPLALANDSTRIVLAGDHMQMSPELFSAFAKERKLHISLLERLYDH 1014
            : ::|..|||:|..| ..::.|.....:....|.||..|:     .|:..:.      |:.|...
 Worm   747 V-SNIQFDEASQVPE-HTLISLLHKFPNASFGLVGDINQL-----PAYCDDD------LQGLLKD 798

  Fly  1015 Y-----------PSNFPCKILLCENYRAHEAIIRFTSELFYEQKLVASGKQPRHDRF-------- 1060
            |           ...||..||... ||.|....:..|:|||..:|::..::.:.|.|
 Worm   799 YGIGKTMARASRDKMFPQSILRLV-YRCHPTTTKILSDLFYNGQLISGVEKNQRDEFMRMRPDIW 862

  Fly  1061 ----YPLTFFTTRGEDVQDKNSTAFYNNAEVYEVVERVSELRKRWPSAWGKLNDTSIGIMTPYSD 1121
                :|:.......:..:...|.|  ||:|..:||..||.|.|: ...:| |:::.|||::.|..
 Worm   863 PNSSFPILVLNHEKDGYRMGTSVA--NNSEKDQVVRIVSLLTKK-VKGYG-LSESDIGIISFYKA 923

  Fly  1122 QVFRIRSELRKR--RMGGISVERVLNVQGKQFRAVFLSTVRTRRTCMPQGSAPGSASTTSIGDAD 1184
            |...:...|:|.  :.|.|..     .||.: |.|.:.....:...:
 Worm   924 QTSLLADALKKTDVKCGTIDA-----FQGTE-REVMIVCCTNKNPSL------------------ 964

  Fly  1185 ADYGFLSNSKLLNTAITRAQSLVAVVGDPVALCSIGRCRKV--WERF-----IEICDEHKSLFG 1241
                |:.....:|.|::||:....::|      :|.:.:|.  |:..     |..|....|.||
 Worm   965 ----FMQEGTRVNVAMSRARQATIIIG------NIAKLKKAKHWDTIAQSAQINKCSMEVSTFG 1018

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Helz	NP_001261848.1	zf-CCCH	329..353	CDD:279036	7/37 (19%)
		TIGR00376	657..1236	CDD:273041	124/684 (18%)
		AAA	810..>886	CDD:99707	20/99 (20%)
		AAA_12	1003..1213	CDD:289832	50/234 (21%)
C44H9.4	NP_506213.2	AAA_11	539..786	CDD:289831	49/258 (19%)
		UvrD_C_2	823..988	CDD:304668	43/202 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148890at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820