DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bmm and pnpla3

DIOPT Version :9

Sequence 1:	NP_001163445.1	Gene:	bmm / 39611	FlyBaseID:	FBgn0036449	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001015693.1	Gene:	pnpla3 / 548410	XenbaseID:	XB-GENE-5855123	Length:	498	Species:	Xenopus tropicalis

Alignment Length:	584	Identity:	194/584 - (33%)
Similarity:	286/584 - (48%)	Gaps:	132/584 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NLSFAGCGFLGIYHVGVAVCFKKYAPHLLLE--KIGGASAGSLAACCLLCDLPLGSMTSDFFRVV 64
            ||||.||||||:|||||:.|.::.||.|:.:  ||.|||||:|.|..|:|...|....||...|.
Frog     9 NLSFCGCGFLGVYHVGVSSCLQERAPRLITQANKIYGASAGALNAAALVCGCSLAQCCSDVLGVA 73

  Fly    65 NEARRYSLGPFSPSFNIQTCLLEGLQKHLPDDAHKRVNGRLHISLTRVYDGKNVIISEFESREEV 129
            .|||:.:|||..||||:...|.:||.::||::||:..:|:|.||||||.||:||::|||.|:||:
Frog    74 KEARKRNLGPLHPSFNLVKILKKGLYRNLPENAHELASGKLCISLTRVSDGENVLVSEFNSKEEL 138

  Fly   130 LQALLCACFIPGFSGILPPRFRGVRYMDGAFSDNLPILD-ENTITVSPFCGESDICPRDQSSQLF 193
            :|||:|:.|:|.:.|::||.||||||:||..|:|||..| :||||||||.|||||||||.:|..|
Frog   139 IQALICSAFVPIYCGLIPPSFRGVRYVDGGISNNLPEYDLKNTITVSPFSGESDICPRDSNSTNF 203

  Fly   194 H-LNWANTSIEISRQNINRFVRILFPPRPEFLSKFCQQGFDDALQFLHRNNLIN-----CRRCVA 252
            | |...||||:.|..|:.|..|.||||.|..|.:.||||::|||:||..|||::     ...|:|
Frog   204 HELRVTNTSIQFSLGNLYRLTRALFPPEPTVLGEMCQQGYNDALRFLKDNNLLSLPSPAADLCLA 268

  Fly   253 VQSTFVVSETVAQPQEFDPECRECKKHRKD-------------------ALSSNMPQTVLDVIQD 298
            ...        |.|......|..|.|.:::                   .:...:|.::..|:|:
Frog   269 FPK--------ATPLSHHLTCDCCVKSKREEEDLKRKVLEGPTPWSLDKRIMERLPPSLCYVLQE 325

  Fly   299 YIEQANKGLANWIFKHRGIKLLS---LPATVPMDFLLATISKISALTPKLTKQARVMVEDLILQL 360
            ...:.| ||.:.|.....:::.|   :|.|:|::.:::...::....|.:.:..|.|.|
Frog   326 ACREKN-GLYHQISSLLPMRVASYMVMPYTLPVESVVSVALRLVDWFPDMPEDMRWMQE------ 383

  Fly   361 NHAMRIRLLNKFTLYDQPHFDATGLLHSSRLYGPRVSILVDECGATPLEDDVDNFEHVLKMTTHN 425
                ::|.: ...:|.|.   ...||.|.|..|...   :.:|.:.|        .|:.:.::
Frog   384 ----QVRSV-AGAVYSQA---KKRLLPSVRSSGHGT---LRKCLSLP--------PHLHRASS-- 427

  Fly   426 DALYAYYYTDSNTNKVKVTE--IFDFDEITEHDKLATDLQIYEGSVEDHPNPHQHSHNTVVSEWN 488
                  |.:.:|.:.....|  :|||.              ....:.||.:|:.
Frog   428 ------YLSPNNFSSAMDLEGWVFDFS--------------CPSLLRDHQDPND----------- 461

  Fly   489 GVESDFFIDAHTPNVEDSKTSAPQFSRLDLETESDAS-----VLSDPEVDQTFSSTASTHSSDM 547
                                  ||     ||.:|||.     .|.|..||..||:.....:|::
Frog   462 ----------------------PQ-----LELDSDAQPKCIFSLEDSGVDVNFSTDPEDSASEL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bmm	NP_001163445.1	Pat_iPLA2	1..245	CDD:132857	137/246 (56%)
pnpla3	NP_001015693.1	Pat_PNPLA2	4..253	CDD:132859	135/243 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I3255
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H120056
Inparanoid	1	1.050	281	1.000	Inparanoid score	I2825
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204225at2759
OrthoFinder	1	1.000	-	-		FOG0000670
OrthoInspector	1	1.000	-	-		mtm9389
Panther	1	1.100	-	-	LDO	PTHR12406
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1585
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.070