DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bmm and PNPLA5

DIOPT Version :9

Sequence 1:	NP_001163445.1	Gene:	bmm / 39611	FlyBaseID:	FBgn0036449	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_620169.1	Gene:	PNPLA5 / 150379	HGNCID:	24888	Length:	429	Species:	Homo sapiens

Alignment Length:	430	Identity:	142/430 - (33%)
Similarity:	222/430 - (51%)	Gaps:	39/430 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NLSFAGCGFLGIYHVGVAVCFKKYAPHLL--LEKIGGASAGSLAACCLLCDLPLGSMTSDFFRVV 64
            ||||:|.|:||.:|||...|.::.||.||  ..:|.|:|:|:|.|..::|...:....|....:|
Human    11 NLSFSGAGYLGAHHVGATECLRQRAPRLLQGARRIYGSSSGALNAVSIVCGKSVDFCCSHLLGMV 75

  Fly    65 NEARRYSLGPFSPSFNIQTCLLEGLQKHLPDDAHKRVNGRLHISLTRVYDGKNVIISEFESREEV 129
            .:..|.||....|::.....:.:.||..||.|||...:.||.|||||..||:|.::::|.:.:|:
Human    76 GQLERLSLSILHPAYAPIEHVKQQLQDALPPDAHVLASQRLGISLTRWPDGRNFLVTDFATCDEL 140

  Fly   130 LQALLCACFIPGFSGILPPRFRGVRYMDGAFSDNLPILD-ENTITVSPFCGESDICPRDQSSQLF 193
            :|||:|..:.|.:.|::||.|||.||:|||.|:|||..| .:|||||||.|..||||:..|..|.
Human   141 IQALVCTLYFPFYCGLIPPEFRGERYIDGALSNNLPFADCPSTITVSPFHGTVDICPQSTSPNLH 205

  Fly   194 HLNWANTSIEISRQNINRFVRILFPPRPEFLSKFCQQGFDDALQFLHRNNLINCRRCVAVQSTFV 258
            .||..|.|.:||.:|....:..|.||..|.::..|:||:.|||:||.|..|..    ..|..|.|
Human   206 ELNVFNFSFQISTENFFLGLICLIPPSLEVVADNCRQGYLDALRFLERRGLTK----EPVLWTLV 266

  Fly   259 VSETVAQPQEFDPECRECKKHRKDALSSN--MPQTVLDVIQDYIEQANKGL------------AN 309
            ..|..| |.:.:.:. .|.:..|..||.|  :|...:..:.:: ||.:..|            :.
Human   267 SKEPPA-PADGNWDA-GCDQRWKGGLSLNWKVPHVQVKDVPNF-EQLSPELEAALKKACTRDPSR 328

  Fly   310 WI-FKHRG----IKLLSLPATVPMDFLLATISKISALTPKLTKQ---ARVMVEDLILQLNHAMRI 366
            |. |.|.|    :..|.||.|:|.:::.....::....|.:...   .:.::.::.|::....:.
Human   329 WARFWHSGPGQVLTYLLLPCTLPFEYIYFRSRRLVVWLPDVPADLWWMQGLLRNMALEVFSRTKA 393

  Fly   367 RLLNKFTLYDQPHFDATGLLHSSRLYGPRVSILVDECGAT 406
            :||...:    |  .||.:|.:|.|. |:::...:|.|.|
Human   394 QLLGPIS----P--PATRVLETSPLQ-PQIAPHREELGPT 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bmm	NP_001163445.1	Pat_iPLA2	1..245	CDD:132857	103/245 (42%)
PNPLA5	NP_620169.1	Pat_PNPLA5-mammals	1..405	CDD:132862	134/406 (33%)
		GXGXXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	16..21		2/4 (50%)
		GXSXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	47..51		2/3 (67%)
		DGA/G. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	168..170		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3773
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	230	1.000	Inparanoid score	I3444
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204225at2759
OrthoFinder	1	1.000	-	-		FOG0000670
OrthoInspector	1	1.000	-	-		mtm8494
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12406
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4990
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.960