Protein Alignment mop and BRO1

DIOPT Version :10

• Sequence 1: NP_648722.2
• Gene: mop / 39610
• FlyBaseID: FBgn0036448
• Length: 1833
• Species: Drosophila melanogaster
• Sequence 2: NP_015241.1
• Gene: BRO1 / 856021
• SGDID: S000006005
• Length: 844
• Species: Saccharomyces cerevisiae
• Alignment Length: 873
• Identity: 198/873 - (22%)
• Similarity: 346/873 - (39%)
• Gaps: 177/873 - (20%)

  Fly    19 EGTSFAALKKYIAE----FYHEDPEAYSKEVHALETLRNQAMHTTKDGAPVM-----KRYYCQLH 74
            :|.|....|.|.:.    ||.|      |....|:.|||.|   ..:.||..     .:||..|.
Yeast    20 KGLSSYLKKSYGSSQWRTFYDE------KATSELDHLRNNA---NGELAPSSLSEQNLKYYSFLE 75

  Fly    75 ALQNRFPQLADRGIFTFKWKDLYHSAV-----HEVTDLRFERAAVLFNIAALHTQSGASVTRGDV 134
            .|..|......|....|.|.|..:|:.     :....|.||::..|||||.:.||    :.|.::
Yeast    76 HLYFRLGSKGSRLKMDFTWYDAEYSSAQKGLKYTQHTLAFEKSCTLFNIAVIFTQ----IARENI 136

  Fly   135 -DGMKMACTHFQAAAWAYGELRERYANVNGGGDFMTPELLVFQQQVCFAQAQECILEKSL---ID 195
             :..|.:..:...|...:..|.|.:  :|.....:..|...|...:|.|:|||..:.|.|   |.
Yeast   137 NEDYKNSIANLTKAFSCFEYLSENF--LNSPSVDLQSENTRFLANICHAEAQELFVLKLLNDQIS 199

  Fly   196 NRKPHIVAKVTAQIVVYYGAALAALLTGGDDGPVAQVIDSSVY--KLWKKYVRFKINYLTCILYL 258
            :::..:::|::        .|...|.....|.......|.::|  ..||..|..|:::...:...
Yeast   200 SKQYTLISKLS--------RATCNLFQKCHDFMKEIDDDVAIYGEPKWKTTVTCKLHFYKSLSAY 256

  Fly   259 YQGQHSEEKRQMGERVTLYQASWDKLEEARKESKGLPDQREINESLSFTA--DVVEAKRKNAKNE 321
            |.|.|.||:.::||.:.....|..:|      ...||.:..:.|.:.|..  :.:|.|:|....:
Yeast   257 YHGLHLEEENRVGEAIAFLDFSMQQL------ISSLPFKTWLVEFIDFDGFKETLEKKQKELIKD 315

  Fly   322 NEFIYHEAVPELSTIAAVQGANLVNGIGFQ------VSDEEHAGPDIFARLVPMKAHEASSLYSE 380
            |:|||||:||.:..:.:::..:.:....::      :.|..:....::..::|:..:|..|:|||
Yeast   316 NDFIYHESVPAVVQVDSIKALDAIKSPTWEKILEPYMQDVANKCDSLYRGIIPLDVYEKESIYSE 380

  Fly   381 EKAKLLRKYGALLEEKDTQLESYMSSLTLDNL--------------NI---NEEQANKLPQGIVD 428
            |||.||||.   :||.:|....|.|.:...||              ||   .:.|...:...|..
Yeast   381 EKATLLRKQ---VEETETANLEYSSFIEFTNLPRLLSDLEKQFSDGNIFSNTDTQGQLMRDQIQT 442

  Fly   429 RCAALNANKTAISDLVEAMS-------QLAEITA----DVETNLGEISSMLEAEAKAEREFQSAT 482
            .|..:..|:  ..|:.|.|:       |:.||.:    |.:.|:.::.|.|.|.:.::.:..:..
Yeast   443 WCKFIQTNE--FRDIEEQMNKIVFKRKQILEILSALPNDQKENVTKLKSSLVAASNSDEKLFACV 505

  Fly   483 GVQRTPNAHITELS------REFQKYSEAHARAGESNNTLRKAMSLHVN---NLKILARPLPEIQ 538
                  ..||.|::      :.::|:.|.      :.||..:...|.::   |.|||
Yeast   506 ------KPHIVEINLLNDNGKIWKKFDEF------NRNTPPQPSLLDIDDTKNDKIL-------- 550

  Fly   539 QLMPKLSSELNTTEIFRDVKLILNKVNEMKAQRAQFHADLRIAINEDDITGKVIAHGGQEG--LQ 601
                         |:.:.||.....:..:|.:|::..::||..||.||||..:|.:.|:..  |:
Yeast   551 -------------ELLKQVKGHAEDLRTLKEERSRNLSELRDEINNDDITKLLIINKGKSDVELK 602

  Fly   602 ALFATELGKHDKITELLDQNMVAQGNILQAL---------TENYA-KAAPVLKTLQDVKQKREHF 656
            .||..||.|.:.::..::..:..|.:::..:         ..|:. |::...|.|:|    |::|
Yeast   603 DLFEVELEKFEPLSTRIEATIYKQSSMIDDIKAKLDEIFHLSNFKDKSSGEEKFLED----RKNF 663

  Fly   657 YSSLAASYDVYEDLLAKSAKGLEFYKKLAGNVQKLLTRFRSARDVQSEERQQRMQSVKAATTPVV 721
            :..|..:...:....:...||:|||..|          |..:||:....|..:......|.:|
Yeast   664 FDKLQEAVKSFSIFASDLPKGIEFYDSL----------FNMSRDLAERVRVAKQTEDSTANSP-- 716

  Fly   722 SKPIAETTPVPAVSSTPKLRDYLKAKAA-----------MADASNPAYVPTVRPVPVGSENP--T 773
            :.|:.......:|...|.|   |..|:|           :.|......:.....:|.|...|  |
Yeast   717 APPLPPLDSKASVVGGPPL---LPQKSAAFQSLSRQGLNLGDQFQNLKISAGSDLPQGPGIPPRT 778

  Fly   774 QAACSYATAPPNEPPP-PYSLTQQQYFD 800
            ..|..||..|....|| |...:|:..:|
Yeast   779 YEASPYAATPTMAAPPVPPKQSQEDMYD 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762	86/371 (23%)
		V_HD-PTP_like	368..702	CDD:185747	88/382 (23%)
		Glutenin_hmw	<795..1261	CDD:367362	2/6 (33%)
		PHA03247	<1329..1443	CDD:223021
		PRK12323	<1378..1540	CDD:481241
		Y_phosphatase	1558..1788	CDD:459674
BRO1	NP_015241.1	BRO1_ScBro1_like	5..347	CDD:185765	85/355 (24%)
		V_ScBro1_like	368..702	CDD:185750	88/385 (23%)