DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and BRO1

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_015241.1	Gene:	BRO1 / 856021	SGDID:	S000006005	Length:	844	Species:	Saccharomyces cerevisiae

Alignment Length:	873	Identity:	198/873 - (22%)
Similarity:	346/873 - (39%)	Gaps:	177/873 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EGTSFAALKKYIAE----FYHEDPEAYSKEVHALETLRNQAMHTTKDGAPVM-----KRYYCQLH 74
            :|.|....|.|.:.    ||.|      |....|:.|||.|   ..:.||..     .:||..|.
Yeast    20 KGLSSYLKKSYGSSQWRTFYDE------KATSELDHLRNNA---NGELAPSSLSEQNLKYYSFLE 75

  Fly    75 ALQNRFPQLADRGIFTFKWKDLYHSAV-----HEVTDLRFERAAVLFNIAALHTQSGASVTRGDV 134
            .|..|......|....|.|.|..:|:.     :....|.||::..|||||.:.||    :.|.::
Yeast    76 HLYFRLGSKGSRLKMDFTWYDAEYSSAQKGLKYTQHTLAFEKSCTLFNIAVIFTQ----IARENI 136

  Fly   135 -DGMKMACTHFQAAAWAYGELRERYANVNGGGDFMTPELLVFQQQVCFAQAQECILEKSL---ID 195
             :..|.:..:...|...:..|.|.:  :|.....:..|...|...:|.|:|||..:.|.|   |.
Yeast   137 NEDYKNSIANLTKAFSCFEYLSENF--LNSPSVDLQSENTRFLANICHAEAQELFVLKLLNDQIS 199

  Fly   196 NRKPHIVAKVTAQIVVYYGAALAALLTGGDDGPVAQVIDSSVY--KLWKKYVRFKINYLTCILYL 258
            :::..:::|::        .|...|.....|.......|.::|  ..||..|..|:::...:...
Yeast   200 SKQYTLISKLS--------RATCNLFQKCHDFMKEIDDDVAIYGEPKWKTTVTCKLHFYKSLSAY 256

  Fly   259 YQGQHSEEKRQMGERVTLYQASWDKLEEARKESKGLPDQREINESLSFTA--DVVEAKRKNAKNE 321
            |.|.|.||:.::||.:.....|..:|      ...||.:..:.|.:.|..  :.:|.|:|....:
Yeast   257 YHGLHLEEENRVGEAIAFLDFSMQQL------ISSLPFKTWLVEFIDFDGFKETLEKKQKELIKD 315

  Fly   322 NEFIYHEAVPELSTIAAVQGANLVNGIGFQ------VSDEEHAGPDIFARLVPMKAHEASSLYSE 380
            |:|||||:||.:..:.:::..:.:....::      :.|..:....::..::|:..:|..|:|||
Yeast   316 NDFIYHESVPAVVQVDSIKALDAIKSPTWEKILEPYMQDVANKCDSLYRGIIPLDVYEKESIYSE 380

  Fly   381 EKAKLLRKYGALLEEKDTQLESYMSSLTLDNL--------------NI---NEEQANKLPQGIVD 428
            |||.||||.   :||.:|....|.|.:...||              ||   .:.|...:...|..
Yeast   381 EKATLLRKQ---VEETETANLEYSSFIEFTNLPRLLSDLEKQFSDGNIFSNTDTQGQLMRDQIQT 442

  Fly   429 RCAALNANKTAISDLVEAMS-------QLAEITA----DVETNLGEISSMLEAEAKAEREFQSAT 482
            .|..:..|:  ..|:.|.|:       |:.||.:    |.:.|:.::.|.|.|.:.::.:..:..
Yeast   443 WCKFIQTNE--FRDIEEQMNKIVFKRKQILEILSALPNDQKENVTKLKSSLVAASNSDEKLFACV 505

  Fly   483 GVQRTPNAHITELS------REFQKYSEAHARAGESNNTLRKAMSLHVN---NLKILARPLPEIQ 538
                  ..||.|::      :.::|:.|.      :.||..:...|.::   |.|||
Yeast   506 ------KPHIVEINLLNDNGKIWKKFDEF------NRNTPPQPSLLDIDDTKNDKIL-------- 550

  Fly   539 QLMPKLSSELNTTEIFRDVKLILNKVNEMKAQRAQFHADLRIAINEDDITGKVIAHGGQEG--LQ 601
                         |:.:.||.....:..:|.:|::..::||..||.||||..:|.:.|:..  |:
Yeast   551 -------------ELLKQVKGHAEDLRTLKEERSRNLSELRDEINNDDITKLLIINKGKSDVELK 602

  Fly   602 ALFATELGKHDKITELLDQNMVAQGNILQAL---------TENYA-KAAPVLKTLQDVKQKREHF 656
            .||..||.|.:.::..::..:..|.:::..:         ..|:. |::...|.|:|    |::|
Yeast   603 DLFEVELEKFEPLSTRIEATIYKQSSMIDDIKAKLDEIFHLSNFKDKSSGEEKFLED----RKNF 663

  Fly   657 YSSLAASYDVYEDLLAKSAKGLEFYKKLAGNVQKLLTRFRSARDVQSEERQQRMQSVKAATTPVV 721
            :..|..:...:....:...||:|||..|          |..:||:....|..:......|.:|
Yeast   664 FDKLQEAVKSFSIFASDLPKGIEFYDSL----------FNMSRDLAERVRVAKQTEDSTANSP-- 716

  Fly   722 SKPIAETTPVPAVSSTPKLRDYLKAKAA-----------MADASNPAYVPTVRPVPVGSENP--T 773
            :.|:.......:|...|.|   |..|:|           :.|......:.....:|.|...|  |
Yeast   717 APPLPPLDSKASVVGGPPL---LPQKSAAFQSLSRQGLNLGDQFQNLKISAGSDLPQGPGIPPRT 778

  Fly   774 QAACSYATAPPNEPPP-PYSLTQQQYFD 800
            ..|..||..|....|| |...:|:..:|
Yeast   779 YEASPYAATPTMAAPPVPPKQSQEDMYD 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762	86/371 (23%)
		V_HD-PTP_like	368..702	CDD:185747	88/382 (23%)
		ALIX_LYPXL_bnd	421..699	CDD:290660	63/309 (20%)
		Med15	808..>1246	CDD:255446
		Y_phosphatase	1558..1788	CDD:278528
		PTPc	1559..1745	CDD:238006
BRO1	NP_015241.1	BRO1_ScBro1_like	5..347	CDD:185765	85/355 (24%)
BRO1	NP_015241.1	V_ScBro1_like	368..702	CDD:185750	88/385 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I1810
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.704428	Normalized mean entropy	S2147
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto100034
orthoMCL	1	0.900	-	-		OOG6_104542
Panther	1	1.100	-	-	O	PTHR23030
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R147
SonicParanoid	1	1.000	-	-		X3427
TreeFam	0	0.000	Not matched by this tool.
	9	8.790