DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and PTP2

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_014851.3	Gene:	PTP2 / 854383	SGDID:	S000005734	Length:	750	Species:	Saccharomyces cerevisiae

Alignment Length:	576	Identity:	123/576 - (21%)
Similarity:	206/576 - (35%)	Gaps:	189/576 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1349 KPEALPPK--VTSNVDLLSDLDIDCSVAVPPP-----MLPQPVLQPQVVATPTPPASQVSVPVKV 1406
            |...:.||  :..||:|.|...::..:.:|||     :..|.:.:..:..:|.          .:
Yeast   208 KKNCILPKLDLNLNVNLTSRSTLNLRINIPPPNDSNKIFLQSLKKDLIHYSPN----------SL 262

  Fly  1407 ESVAEHAAPATAEIPVAATEGTAQTPVTIPSGPKCAS--------LDNLSNCSDLSSLENFDWDS 1463
            :...:...||          ..|.....:|:..|..|        |..|.|  :..:||||:...
Yeast   263 QKFFQFNMPA----------DLAPNDTILPNWLKFCSVKENEKVILKKLFN--NFETLENFEMQR 315

  Fly  1464 VSVTHSVSEK---QTKASATANGHSSSFAFQSETFTDEKTTKYFQKEVESYEKLLENLHVKMLNG 1525
            :.......:|   |.:.|....|..|:  ..|:.::.....:.::..::|  .:.:|..:|::..
Yeast   316 LEKCLKFKKKPLHQKQLSQKQRGPQST--DDSKLYSLTSLQRQYKSSLKS--NIQKNQKLKLIIP 376

  Fly  1526 KTQLGAKWQELQQK-------LDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKL------- 1576
            |....:....|...       .|.|.....:|.|       |||..:.|||:|:||||
Yeast   377 KNNTSSSPSPLSSDDTIMSPINDYELTEGIQSFT-------KNRYSNILPYEHSRVKLPHSPKPP 434

  Fly  1577 --------DKQTD------------------DYINAAYMKNLSAGCPNF--IVAQTPQPNTINDF 1613
                    :.:||                  |||||.|:| |:...|:|  |..|.|.|:|::||
Yeast   435 AVSEASTTETKTDKSYPMCPVDAKNHSCKPNDYINANYLK-LTQINPDFKYIATQAPLPSTMDDF 498

  Fly  1614 WSMIWSEKSRTVVCLHTPNEL----FDPYWPQALDQPTHYDDYTVT-------------C-LKVQ 1660
            |.:|...|.:.::.|::.:||    :|.||     ....|.::|:.             | |:|.
Yeast   499 WKVITLNKVKVIISLNSDDELNLRKWDIYW-----NNLSYSNHTIKLQNTWENICNINGCVLRVF 558

  Fly  1661 QLSHCSEYQLKLSM-----HGAD------AVLD---LSLLQLKQWTKGAPAQL-----LGVAENA 1706
            |:...:.....:|.     |..|      ||.:   :..||.|.|.......:     |...:|:
Yeast   559 QVKKTAPQNDNISQDCDLPHNGDLTSITMAVSEPFIVYQLQYKNWLDSCGVDMNDIIKLHKVKNS 623

  Fly  1707 L---------ETHRQRCK--------------AANAPQSPLIMNCLTGSERSE-------LVAIG 1741
            |         ...:..||              .||:  |||:::|..|..|:.       |::|
Yeast   624 LLFNPQSFITSLEKDVCKPDLIDDNNSELHLDTANS--SPLLVHCSAGCGRTGVFVTLDFLLSI- 685

  Fly  1742 VCAIIATQNKQPILLNTIDVWSRICAQRQ-------NSLRDSAI--LEQSMQIVLC 1788
               :..|.|..    |.||||:    ..|       |.||...|  ::...|.:.|
Yeast   686 ---LSPTTNHS----NKIDVWN----MTQDLIFIIVNELRKQRISMVQNLTQYIAC 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446
		Y_phosphatase	1558..1788	CDD:278528	82/340 (24%)
		PTPc	1559..1745	CDD:238006	69/287 (24%)
PTP2	NP_014851.3	COG5599	344..748	CDD:227886	93/416 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900