DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mop and PTPRZ1

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_002842.2	Gene:	PTPRZ1 / 5803	HGNCID:	9685	Length:	2315	Species:	Homo sapiens

Alignment Length:	1841	Identity:	370/1841 - (20%)
Similarity:	600/1841 - (32%)	Gaps:	585/1841 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 EEARKESKGLPDQREINESLSFTADVVEAKRKNAKNENEFIYHEAVPELSTIAAVQGANLVNGIG 349
            ||..||.:   :.::|.|..     :|...|.:|.|:    ..:..|::||      ....|.||
Human   425 EEIIKEEE---EGKDIEEGA-----IVNPGRDSATNQ----IRKKEPQIST------TTHYNRIG 471

  Fly   350 FQVSD----------EEHAGP-DIFARLVPMKAHEASSLYSEEKAKLLRK-------------YG 390
            .:.::          .|.:|. |:....:...:...:.|.:|:...|..:             ..
Human   472 TKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSA 536

  Fly   391 ALLEEKDTQLESYMSSL-----TLDNLNINEEQAN------KLPQGIVDRCAALNANKTAISDLV 444
            :|.:...|.|.|...:|     :|:.::|.|.:..      ||..|..|...:..|. :||..:.
Human   537 SLNDGSKTVLRSPHMNLSGTAESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPAT-SAIPFIS 600

  Fly   445 EAMSQ--------LAEITADV------------ETNLGEISSMLEAEAKAEREFQSATGVQRTPN 489
            |.:||        ...||.||            .|:.|...|:.:...:....|.|:|.:...|:
Human   601 ENISQGYIFSSENPETITYDVLIPESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPD 665

  Fly   490 AHITELSREFQKYSEAHARAGESNNTLRKAMSLHVNNLKILARPL----PEIQQL-MPKLS---- 545
              :......|.:.:....|..||..| .|:.|         |.|:    |.:..| ||..|
Human   666 --VGSGRESFLQTNYTEIRVDESEKT-TKSFS---------AGPVMSQGPSVTDLEMPHYSTFAY 718

  Fly   546 --SELNT---TEIFRDVKLILNKVNEMKAQRAQFHADLRIAINEDDITGKVIAHGGQEGLQALFA 605
              :|:..   |...|...|: :.||.:.:|..|                  ..:.|:..||..::
Human   719 FPTEVTPHAFTPSSRQQDLV-STVNVVYSQTTQ------------------PVYNGETPLQPSYS 764

  Fly   606 TELGKHDKITELLDQNMVAQGNILQALTENYAKAAPVLKTLQDVKQKREHFYSSLAASYDVYEDL 670
            :|:  ...:|.||..|.:.......:.:::...|.||..:: ||.      :.|:.:|||....|
Human   765 SEV--FPLVTPLLLDNQILNTTPAASSSDSALHATPVFPSV-DVS------FESILSSYDGAPLL 820

  Fly   671 LAKSAKGLEFYKKLAGNVQKLLTRFRSARDVQSEERQQRMQSVKAATTPVVSKPIAETTPVPAVS 735
            ...||   .|..:|          ||....|     .|.:..|.:||         |:..||..:
Human   821 PFSSA---SFSSEL----------FRHLHTV-----SQILPQVTSAT---------ESDKVPLHA 858

  Fly   736 STPKLRDYLKAKAAMADASNPAYVPTVRPVPVGSENPTQAACSYAT------APPNE-------- 786
            |.|.....|..:.::|..|:  .:.|........|..:::...|.|      .||:.
Human   859 SLPVAGGDLLLEPSLAQYSD--VLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSDAMMHARS 921

  Fly   787 --PPPPYSLT----QQQYFDPS---------AAGYTNPMYQ----QQQQHIAPPAYKAQASPNS- 831
              |.|.|:|:    .|..|..|         :.|.|   ||    ....||..|. .:..:|.:
Human   922 SGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVT---YQGSLFSGPSHIPIPK-SSLITPTAS 982

  Fly   832 --QTLHGALGQMNLQGQSQDNNQAGMAYNYGYPSGSVPPLAYAPPGTVPASSASQGLNIQQPLYV 894
              |..|...|.....|.|.|:.                       ..:|.:.....|||..|:.|
Human   983 LLQPTHALSGDGEWSGASSDSE-----------------------FLLPDTDGLTALNISSPVSV 1024

  Fly   895 A-----TS--GNPVSVSNPSEL----PSTLQAPF---VVNP-----MSNPYQTAAGYSGQAYQQV 940
            |     ||  |:.....:.||:    .:.||.|.   :|.|     |.|.|...        .::
Human  1025 AEFTYTTSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNV--------NKL 1081

  Fly   941 NAQAQQVTYPTAPSGSST--------GQSAQQPLGYAPSQGPQ-----------QQAGGYPQSQT 986
            ||..|:    |:.|.|||        ..:..:...:..||.|:           .||.|    .|
Human  1082 NASLQE----TSVSISSTKGMFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASG----DT 1138

  Fly   987 PQQQVGAYQQQPLS---GYAQQLTPQQQTGYSQSQA----PQLQAPSYAQNQQSTGQAQQQQTGY 1044
            ..:.|.:...:|.|   ..::.|:|..|..:.::.|    ..|..||:..:...|    ..:|..
Human  1139 SLKPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASDVDT----LLKTVL 1199

  Fly  1045 PQTPQQ-----------------HL--AGYAQSQQ------------QATGYPQSQTSQQQTTGY 1078
            |..|..                 ||  :..|.|:.            ..|.:..|.:.|..|..|
Human  1200 PAVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGLTISY 1264

  Fly  1079 SQSQTPQQPLAYQQQPSGYPQQQQQQSLAPQQPSLYPS-QAVQASPQPIPGQQATPPNAGQPLPY 1142
            :..:       |:      |...:.:|.....||||.: :..|.:...|  .||.||........
Human  1265 ASEK-------YE------PVLLKSESSHQVVPSLYSNDELFQTANLEI--NQAHPPKGRHVFAT 1314

  Fly  1143 P---------------------QQYTDPNAAPAPAPGVSSVPSPVPVPT----PAPTSSQAQVPT 1182
            |                     ...|..:.......|:.:|.|...|.|    |......|....
Human  1315 PVLSIDEPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSVPIGNGHVAITAV 1379

  Fly  1183 SPHPSATYTSYSNHPGYSFNPQTGKYEYSSGYQQDTSSLKGSQ---------------------- 1225
            |||...:.||..     ...|.....|.|...:.|...:.|.:
Human  1380 SPHRDGSVTSTK-----LLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSI 1439

  Fly  1226 ----ASQSYQFSQSGKQQSVGTTDSEIASRSNTATGFDSPIVSHTKVNMAAKDSTSAIEGNESSN 1286
                :..||:.||........|.::.:..::|       ||            |.|..|.:|..|
Human  1440 HKCMSCSSYRESQEKVMNDSDTHENSLMDQNN-------PI------------SYSLSENSEEDN 1485

  Fly  1287 YYSTPYGYLGSVNPQQQ------PTPAPPSNSTASIYMQSGASSTAETQTTSSGVPYASS----A 1341
            ..:       ||:...|      |..:|.:|..:.  ..:......:.||.|:.:|.:..    |
Human  1486 RVT-------SVSSDSQTGMDRSPGKSPSANGLSQ--KHNDGKEENDIQTGSALLPLSPESKAWA 1541

  Fly  1342 ALTKVEPK------PEALPPKVTSNVDLLSDL---DIDCSVAVP----PPMLPQPVLQPQVVATP 1393
            .||..|..      .::|....||.....:|.   |.|..:|..    .|..||
Human  1542 VLTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQ----------- 1595

  Fly  1394 TPPASQVSVPVKVESVAE-HAAPATAEIPVAATEG-----TAQTPVTIPSG-------------- 1438
            :|.:|..|...:|..|:| .|:.::.|..:...||     .|..|:.|.|.
Human  1596 SPTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILI 1660

  Fly  1439 --PKCAS-----LDNLSNCSDLSSLE------NFDWDSVSVTHSVSEKQTKASATANGHSSSFAF 1490
              .||..     |::.::...:|:..      :.|..::.:.|....       .|:.|:||
Human  1661 YWRKCFQTAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKH-------VADLHASS--- 1715

  Fly  1491 QSETFTDE-KTTKYFQKEVESYEKLLENLHVKMLNGKTQLGAKWQELQQKLDKEAAANKRSTTIA 1554
               .||:| :|.|.|.:||:|.              ...||.                   |..:
Human  1716 ---GFTEEFETLKEFYQEVQSC--------------TVDLGI-------------------TADS 1744

  Fly  1555 KLFPE---KNRSLDCLPYDHARVKL------DKQTDDYINAAYMKNLSAGCPN-FIVAQTPQPNT 1609
            ...|:   |||.::.:.|||:||||      |.:..|||||.|:...:.  |. :|.||.|..:|
Human  1745 SNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNR--PKAYIAAQGPLKST 1807

  Fly  1610 INDFWSMIWSEKSRTVVCL----HTPNELFDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQL 1670
            ..|||.|||......:|.:    .......|.|||  .|....|.::.||...||.|::.:....
Human  1808 AEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--ADGSEEYGNFLVTQKSVQVLAYYTVRNF 1870

  Fly  1671 KL--------SMHGADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCKAANAPQ---SPL 1724
            .|        |..|..:...::.....||..      :||.|.:|.......|||.|.:   .|:
Human  1871 TLRNTKIKKGSQKGRPSGRVVTQYHYTQWPD------MGVPEYSLPVLTFVRKAAYAKRHAVGPV 1929

  Fly  1725 IMNCLTGSERSELVAIGVCAIIATQNKQPILLNTIDVW---SRICAQRQNSLRD----------- 1775
            :::|..|..|:     |...::.:..:|.....|::::   ..|.:||...::.
Human  1930 VVHCSAGVGRT-----GTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTL 1989

  Fly  1776 -SAILEQSMQIVLCNAHNVLN 1795
             .|||.:..:::..:.|..:|
Human  1990 VEAILSKETEVLDSHIHAYVN 2010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762	19/88 (22%)
		V_HD-PTP_like	368..702	CDD:185747	78/391 (20%)
		ALIX_LYPXL_bnd	421..699	CDD:290660	67/311 (22%)
		Med15	808..>1246	CDD:255446	107/572 (19%)
		Y_phosphatase	1558..1788	CDD:278528	68/269 (25%)
		PTPc	1559..1745	CDD:238006	59/210 (28%)
PTPRZ1	NP_002842.2	PARM	1089..>1255	CDD:293666	30/173 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1123..1160		7/40 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1397..1523		23/153 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1543..1572		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1584..1621		10/47 (21%)
		PTPc	1716..1991	CDD:214550	77/322 (24%)
		PTPc	1752..1991	CDD:238006	64/253 (25%)
		Substrate binding. /evidence=ECO:0000250	1933..1939		2/5 (40%)
		PTPc	2022..2280	CDD:214550
		PTPc	2050..2280	CDD:238006
		alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..401	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..462		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..507		3/29 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	628..650		3/21 (14%)
		MFMR	684..>763	CDD:285072	23/107 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810