DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mop and PTPRZ1

DIOPT Version :10

Sequence 1:NP_648722.2 Gene:mop / 39610 FlyBaseID:FBgn0036448 Length:1833 Species:Drosophila melanogaster
Sequence 2:NP_002842.2 Gene:PTPRZ1 / 5803 HGNCID:9685 Length:2315 Species:Homo sapiens


Alignment Length:1841 Identity:370/1841 - (20%)
Similarity:600/1841 - (32%) Gaps:585/1841 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   285 EEARKESKGLPDQREINESLSFTADVVEAKRKNAKNENEFIYHEAVPELSTIAAVQGANLVNGIG 349
            ||..||.:   :.::|.|..     :|...|.:|.|:    ..:..|::||      ....|.||
Human   425 EEIIKEEE---EGKDIEEGA-----IVNPGRDSATNQ----IRKKEPQIST------TTHYNRIG 471

  Fly   350 FQVSD----------EEHAGP-DIFARLVPMKAHEASSLYSEEKAKLLRK-------------YG 390
            .:.::          .|.:|. |:....:...:...:.|.:|:...|..:             ..
Human   472 TKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSA 536

  Fly   391 ALLEEKDTQLESYMSSL-----TLDNLNINEEQAN------KLPQGIVDRCAALNANKTAISDLV 444
            :|.:...|.|.|...:|     :|:.::|.|.:..      ||..|..|...:..|. :||..:.
Human   537 SLNDGSKTVLRSPHMNLSGTAESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPAT-SAIPFIS 600

  Fly   445 EAMSQ--------LAEITADV------------ETNLGEISSMLEAEAKAEREFQSATGVQRTPN 489
            |.:||        ...||.||            .|:.|...|:.:...:....|.|:|.:...|:
Human   601 ENISQGYIFSSENPETITYDVLIPESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPD 665

  Fly   490 AHITELSREFQKYSEAHARAGESNNTLRKAMSLHVNNLKILARPL----PEIQQL-MPKLS---- 545
              :......|.:.:....|..||..| .|:.|         |.|:    |.:..| ||..|    
Human   666 --VGSGRESFLQTNYTEIRVDESEKT-TKSFS---------AGPVMSQGPSVTDLEMPHYSTFAY 718

  Fly   546 --SELNT---TEIFRDVKLILNKVNEMKAQRAQFHADLRIAINEDDITGKVIAHGGQEGLQALFA 605
              :|:..   |...|...|: :.||.:.:|..|                  ..:.|:..||..::
Human   719 FPTEVTPHAFTPSSRQQDLV-STVNVVYSQTTQ------------------PVYNGETPLQPSYS 764

  Fly   606 TELGKHDKITELLDQNMVAQGNILQALTENYAKAAPVLKTLQDVKQKREHFYSSLAASYDVYEDL 670
            :|:  ...:|.||..|.:.......:.:::...|.||..:: ||.      :.|:.:|||....|
Human   765 SEV--FPLVTPLLLDNQILNTTPAASSSDSALHATPVFPSV-DVS------FESILSSYDGAPLL 820

  Fly   671 LAKSAKGLEFYKKLAGNVQKLLTRFRSARDVQSEERQQRMQSVKAATTPVVSKPIAETTPVPAVS 735
            ...||   .|..:|          ||....|     .|.:..|.:||         |:..||..:
Human   821 PFSSA---SFSSEL----------FRHLHTV-----SQILPQVTSAT---------ESDKVPLHA 858

  Fly   736 STPKLRDYLKAKAAMADASNPAYVPTVRPVPVGSENPTQAACSYAT------APPNE-------- 786
            |.|.....|..:.::|..|:  .:.|........|..:::...|.|      .||:.        
Human   859 SLPVAGGDLLLEPSLAQYSD--VLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSDAMMHARS 921

  Fly   787 --PPPPYSLT----QQQYFDPS---------AAGYTNPMYQ----QQQQHIAPPAYKAQASPNS- 831
              |.|.|:|:    .|..|..|         :.|.|   ||    ....||..|. .:..:|.: 
Human   922 SGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVT---YQGSLFSGPSHIPIPK-SSLITPTAS 982

  Fly   832 --QTLHGALGQMNLQGQSQDNNQAGMAYNYGYPSGSVPPLAYAPPGTVPASSASQGLNIQQPLYV 894
              |..|...|.....|.|.|:.                       ..:|.:.....|||..|:.|
Human   983 LLQPTHALSGDGEWSGASSDSE-----------------------FLLPDTDGLTALNISSPVSV 1024

  Fly   895 A-----TS--GNPVSVSNPSEL----PSTLQAPF---VVNP-----MSNPYQTAAGYSGQAYQQV 940
            |     ||  |:.....:.||:    .:.||.|.   :|.|     |.|.|...        .::
Human  1025 AEFTYTTSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNV--------NKL 1081

  Fly   941 NAQAQQVTYPTAPSGSST--------GQSAQQPLGYAPSQGPQ-----------QQAGGYPQSQT 986
            ||..|:    |:.|.|||        ..:..:...:..||.|:           .||.|    .|
Human  1082 NASLQE----TSVSISSTKGMFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASG----DT 1138

  Fly   987 PQQQVGAYQQQPLS---GYAQQLTPQQQTGYSQSQA----PQLQAPSYAQNQQSTGQAQQQQTGY 1044
            ..:.|.:...:|.|   ..::.|:|..|..:.::.|    ..|..||:..:...|    ..:|..
Human  1139 SLKPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASDVDT----LLKTVL 1199

  Fly  1045 PQTPQQ-----------------HL--AGYAQSQQ------------QATGYPQSQTSQQQTTGY 1078
            |..|..                 ||  :..|.|:.            ..|.:..|.:.|..|..|
Human  1200 PAVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGLTISY 1264

  Fly  1079 SQSQTPQQPLAYQQQPSGYPQQQQQQSLAPQQPSLYPS-QAVQASPQPIPGQQATPPNAGQPLPY 1142
            :..:       |:      |...:.:|.....||||.: :..|.:...|  .||.||........
Human  1265 ASEK-------YE------PVLLKSESSHQVVPSLYSNDELFQTANLEI--NQAHPPKGRHVFAT 1314

  Fly  1143 P---------------------QQYTDPNAAPAPAPGVSSVPSPVPVPT----PAPTSSQAQVPT 1182
            |                     ...|..:.......|:.:|.|...|.|    |......|....
Human  1315 PVLSIDEPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSVPIGNGHVAITAV 1379

  Fly  1183 SPHPSATYTSYSNHPGYSFNPQTGKYEYSSGYQQDTSSLKGSQ---------------------- 1225
            |||...:.||..     ...|.....|.|...:.|...:.|.:                      
Human  1380 SPHRDGSVTSTK-----LLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSI 1439

  Fly  1226 ----ASQSYQFSQSGKQQSVGTTDSEIASRSNTATGFDSPIVSHTKVNMAAKDSTSAIEGNESSN 1286
                :..||:.||........|.::.:..::|       ||            |.|..|.:|..|
Human  1440 HKCMSCSSYRESQEKVMNDSDTHENSLMDQNN-------PI------------SYSLSENSEEDN 1485

  Fly  1287 YYSTPYGYLGSVNPQQQ------PTPAPPSNSTASIYMQSGASSTAETQTTSSGVPYASS----A 1341
            ..:       ||:...|      |..:|.:|..:.  ..:......:.||.|:.:|.:..    |
Human  1486 RVT-------SVSSDSQTGMDRSPGKSPSANGLSQ--KHNDGKEENDIQTGSALLPLSPESKAWA 1541

  Fly  1342 ALTKVEPK------PEALPPKVTSNVDLLSDL---DIDCSVAVP----PPMLPQPVLQPQVVATP 1393
            .||..|..      .::|....||.....:|.   |.|..:|..    .|..||           
Human  1542 VLTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQ----------- 1595

  Fly  1394 TPPASQVSVPVKVESVAE-HAAPATAEIPVAATEG-----TAQTPVTIPSG-------------- 1438
            :|.:|..|...:|..|:| .|:.::.|..:...||     .|..|:.|.|.              
Human  1596 SPTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILI 1660

  Fly  1439 --PKCAS-----LDNLSNCSDLSSLE------NFDWDSVSVTHSVSEKQTKASATANGHSSSFAF 1490
              .||..     |::.::...:|:..      :.|..::.:.|....       .|:.|:||   
Human  1661 YWRKCFQTAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKH-------VADLHASS--- 1715

  Fly  1491 QSETFTDE-KTTKYFQKEVESYEKLLENLHVKMLNGKTQLGAKWQELQQKLDKEAAANKRSTTIA 1554
               .||:| :|.|.|.:||:|.              ...||.                   |..:
Human  1716 ---GFTEEFETLKEFYQEVQSC--------------TVDLGI-------------------TADS 1744

  Fly  1555 KLFPE---KNRSLDCLPYDHARVKL------DKQTDDYINAAYMKNLSAGCPN-FIVAQTPQPNT 1609
            ...|:   |||.::.:.|||:||||      |.:..|||||.|:...:.  |. :|.||.|..:|
Human  1745 SNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNR--PKAYIAAQGPLKST 1807

  Fly  1610 INDFWSMIWSEKSRTVVCL----HTPNELFDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQL 1670
            ..|||.|||......:|.:    .......|.|||  .|....|.::.||...||.|::.:....
Human  1808 AEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--ADGSEEYGNFLVTQKSVQVLAYYTVRNF 1870

  Fly  1671 KL--------SMHGADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCKAANAPQ---SPL 1724
            .|        |..|..:...::.....||..      :||.|.:|.......|||.|.:   .|:
Human  1871 TLRNTKIKKGSQKGRPSGRVVTQYHYTQWPD------MGVPEYSLPVLTFVRKAAYAKRHAVGPV 1929

  Fly  1725 IMNCLTGSERSELVAIGVCAIIATQNKQPILLNTIDVW---SRICAQRQNSLRD----------- 1775
            :::|..|..|:     |...::.:..:|.....|::::   ..|.:||...::.           
Human  1930 VVHCSAGVGRT-----GTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTL 1989

  Fly  1776 -SAILEQSMQIVLCNAHNVLN 1795
             .|||.:..:::..:.|..:|
Human  1990 VEAILSKETEVLDSHIHAYVN 2010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mopNP_648722.2 BRO1_HD-PTP_like 2..363 CDD:185762 19/88 (22%)
V_HD-PTP_like 368..702 CDD:185747 78/391 (20%)
Glutenin_hmw <795..1261 CDD:367362 113/609 (19%)
PHA03247 <1329..1443 CDD:223021 34/152 (22%)
PRK12323 <1378..1540 CDD:481241 38/195 (19%)
Y_phosphatase 1558..1788 CDD:459674 68/269 (25%)
PTPRZ1NP_002842.2 alpha_CARP_receptor_like 45..298 CDD:239396
fn3 313..401 CDD:394996
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 442..462 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..507 3/29 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 628..650 3/21 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1123..1160 7/40 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1397..1523 23/153 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1543..1572 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1584..1621 10/47 (21%)
PTP_DSP_cys 1717..1994 CDD:475123 78/324 (24%)
R-PTP-Z-2 2077..2280 CDD:350507
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.