DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and PTPRR

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_002840.2	Gene:	PTPRR / 5801	HGNCID:	9680	Length:	657	Species:	Homo sapiens

Alignment Length:	425	Identity:	98/425 - (23%)
Similarity:	152/425 - (35%)	Gaps:	102/425 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1378 PMLPQPVL-QPQVVATPTPPASQVSVPVKVESVAEHAAPATAEIPVAATEGTAQTPVTI-PSGPK 1440
            |:..||.| :.:.|.:...|.   ..|..:..|.:.......||..........:|..: |.|.:
Human   273 PITLQPALSEAKTVHSMVQPE---QAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQ 334

  Fly  1441 CASLDNLSNCSDLSSLENFDWDSVSVTHSVSEKQTKASATANGHSSSFAFQSETFTDEKTTKYFQ 1505
            .....|:|...|:|||.|.:                            .|.|.....||....:
Human   335 ERRGSNVSLTLDMSSLGNIE----------------------------PFVSIPTPREKVAMEY- 370

  Fly  1506 KEVESYEKLLENLHVK-MLNGKTQLGAKWQELQQKL--DKEAAANKRSTTIAKLFPEKNRSLDCL 1567
              ::|..::|....:: ::.....|.:::.|:....  .||....:..|        |||....|
Human   371 --LQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGT--------KNRYKTIL 425

  Fly  1568 PYDHARVKLDKQ--TDD---YINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVC 1627
            |...:||.|..:  ||.   ||||.|::..|.....||..|.|..||::|||.|:|.|.|..:|.
Human   426 PNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVM 490

  Fly  1628 ---LHTPNELFDPYWPQ----------ALDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADA 1679
               |...||....|||:          .:......|:||:..|.::|.||....:........|.
Human   491 ITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDH 555

  Fly  1680 VLDLS---LLQLKQWTKGAPAQLLGVAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVAIG 1741
            ....|   ||||          :|.|.|:.|         |:..:.|::::|..|..|:.
Human   556 KTPDSAQPLLQL----------MLDVEEDRL---------ASQGRGPVVVHCSAGIGRTG----- 596

  Fly  1742 VCAIIAT-----QNKQPILLNTIDVWSRICAQRQN 1771
              ..|||     |.|:.   ..:|..|.:|..|.:
Human   597 --CFIATSIGCQQLKEE---GVVDALSIVCQLRMD 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446
		Y_phosphatase	1558..1788	CDD:278528	67/240 (28%)
		PTPc	1559..1745	CDD:238006	58/206 (28%)
PTPRR	NP_002840.2	PTPc	392..644	CDD:214550	72/272 (26%)
PTPRR	NP_002840.2	PTPc	417..644	CDD:238006	68/247 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900