DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and PTPRG

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_016862450.1	Gene:	PTPRG / 5793	HGNCID:	9671	Length:	1485	Species:	Homo sapiens

Alignment Length:	1395	Identity:	265/1395 - (18%)
Similarity:	468/1395 - (33%)	Gaps:	450/1395 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   657 YSSLAASYDVYEDLLAKSAKGLEFYKKLAGNVQKLLTRFRSARDVQSEERQQRMQSVKAATTPVV 721
            |..|.|.|.::........|.:|:          |...||.         |||:..      .||
Human   318 YHQLEAFYSIFTTEQQDHVKSVEY----------LRNNFRP---------QQRLHD------RVV 357

  Fly   722 SKPIAETTPVPAVSSTPKLRDYLK----AKAAMADASNPAYVPTVRPVPVGSENPTQAACSYATA 782
            ||.....      |....:.|:|:    .:|:...:|.|.:: .|:|:     |.|....|::..
Human   358 SKSAVRD------SWNHDMTDFLENPLGTEASKVCSSPPIHM-KVQPL-----NQTALQVSWSQP 410

  Fly   783 PPNEPPP------PYSLTQQQYFDPSAAGYTNPMYQQQQ---QHIAPPA---YKAQA-------S 828
            .....||      .||.|:.:  |.....:|....:..:   .|::|.:   ::.||       |
Human   411 ETIYHPPIMNYMISYSWTKNE--DEKEKTFTKDSDKDLKATISHVSPDSLYLFRVQAVCRNDMRS 473

  Fly   829 PNSQTLHGALGQMNLQGQSQDNNQAGMAYNYGYPSGSVPPLAYAPPGTVPASSA---SQGL---- 886
            ..|||       |..|..:....|.......|.|:.|  |.:.|....:.:.|:   |.|:
Human   474 DFSQT-------MLFQANTTRIFQGTRIVKTGVPTAS--PASSADMAPISSGSSTWTSSGIPFSF 529

  Fly   887 -NIQQPLYVATSGNPVSVSNPSELPSTLQA------------PFVVNPMSNPYQTAAGYSGQAYQ 938
             ::...:..::||:..:|:  |.:.|||.|            |..|.|...|  |||..|.||.:
Human   530 VSMATGMGPSSSGSQATVA--SVVTSTLLAGLGFGGGGISSFPSTVWPTRLP--TAASASKQAAR 590

  Fly   939 QVNAQAQQVTYPTAPSGSSTGQSAQQPLGYAPSQGPQQQAGGYPQSQTPQQQVGAYQQQPLSGYA 1003
            .|.|..:.:..| .|.|.|:....    |....:|.:.:..   :|:..:::
Human   591 PVLATTEALASP-GPDGDSSPTKD----GEGTEEGEKDEKS---ESEDGERE------------- 634

  Fly  1004 QQLTPQQQTGYSQSQAPQLQAPSYAQNQQSTGQAQQQQTGYPQTPQQHLAGYAQS----QQQATG 1064
                 .::.|...|:..:....::|..:::    |.:.:..|.:|.:...|..|:    :|..|.
Human   635 -----HEEDGEKDSEKKEKSGVTHAAEERN----QTEPSPTPSSPNRTAEGGHQTIPGHEQDHTA 690

  Fly  1065 YPQSQTSQQQTTG-------YSQSQTPQQPLAYQQQPSGYPQQQQQQSLAPQQPSLYP------- 1115
            .|..||..::..|       .:.:|.|  |.|.::|.:|...::      |:.||..|
Human   691 VPTDQTGGRRDAGPGLDPDMVTSTQVP--PTATEEQYAGSDPKR------PEMPSKKPMSRGDRF 747

  Fly  1116 ---SQAVQASP----------QPIPGQ------------------------------------QA 1131
               |:.:..:|          :|.||:                                    :.
Human   748 SEDSRFITVNPAEKNTSGMISRPAPGRMEWIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKG 812

  Fly  1132 TP------PNAGQP--------LPYPQQYTDPNAAPAPAPGVSSVPSPVPVPTPAPTSSQAQVPT 1182
            .|      |::|:.        ......|.:.:::|...|..|     :|: .|.|...:| :|.
Human   813 FPRRFREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNES-----IPI-IPIPDDMEA-IPV 870

  Fly  1183 SPHPSATYTSYSNHPG--YSFNPQTGKYEYSSGYQQDTSSLKGSQASQSYQFSQSGKQQSVGTTD 1245
            .        .:..|.|  ||.|        ..|:.:|...::...|..:.....|..      .:
Human   871 K--------QFVKHIGELYSNN--------QHGFSEDFEEVQRCTADMNITAEHSNH------PE 913

  Fly  1246 SEIASRSNTATGFDSPIVSHTKVN---MAAKDSTSAIEGNESSNY---YSTPYGYLGSVNP---- 1300
            ::..:|......:|     |::|.   :..|||..:...|  :||   |:....|:.:..|
Human   914 NKHKNRYINILAYD-----HSRVKLRPLPGKDSKHSDYIN--ANYVDGYNKAKAYIATQGPLKST 971

  Fly  1301 ---------QQQPTPAPPSNSTASIYM-----QSGASSTAETQTTSSGVPYAS------------ 1339
                     :|         :|..|.|     :.|.....:...|.:...|.:
Human   972 FEDFWRMIWEQ---------NTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHA 1027

  Fly  1340 -------SAALTKVEPKPEALPPKVTSNVDLLSDLDIDCSVAVPPPMLPQPVLQPQVVATPTPPA 1397
                   |...|||: |.:...||...|                    .:.|:|......|....
Human  1028 CYTVRRFSIRNTKVK-KGQKGNPKGRQN--------------------ERVVIQYHYTQWPDMGV 1071

  Fly  1398 SQVSVPVKVESVAEHAA--PATAEIPVAATEGTAQTPVTIPSGPKCASLDNLSNCSDLSSLENFD 1460
            .:.::||........||  |.|..:.|..:.|..:|...|       .:|::     |..::  |
Human  1072 PEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYI-------VIDSM-----LQQIK--D 1122

  Fly  1461 WDSVSVTHSVSEKQTKASATANGHSSSFAFQSETFTDE---KTTKYFQKEVESYEKLLENLHVKM 1522
            ..:|:|...:...:|:.:.... ....:.|..:...:.   |.|:....::.||   :.::.:..
Human  1123 KSTVNVLGFLKHIRTQRNYLVQ-TEEQYIFIHDALLEAILGKETEVSSNQLHSY---VNSILIPG 1183

  Fly  1523 LNGKTQL----------GAKWQELQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKL- 1576
            :.|||:|          .||:.|.   ...:...||          ||||:...:|.:.|||.|
Human  1184 VGGKTRLEKQFKLVTQCNAKYVEC---FSAQKECNK----------EKNRNSSVVPSERARVGLA 1235

  Fly  1577 ---DKQTDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFDP- 1637
               ..:..|||||:|:...... ..||:.|.|.|:|..|||.|||...::.:|.|.....|.:.
Human  1236 PLPGMKGTDYINASYIMGYYRS-NEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE 1299

  Fly  1638 --YWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQL-----KLSMHGADAVLDLSLLQLKQW-TKG 1694
              ||| :.::..:.:.:|||.:...:|...:|.|:     .|.....|.||::...|..:| ...
Human  1300 FVYWP-SREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPD 1363

  Fly  1695 APA----QLLGVAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVAIGVCAIIATQNKQPIL 1755
            ||.    :|:.|.:....|.          ..|.|::...|:     |:.|:...:.|.::|...
Human  1364 APISSTFELINVIKEEALTR----------DGPTIVHDEYGA-----VSAGMLCALTTLSQQLEN 1413

  Fly  1756 LNTIDVWSRICAQRQNSLRDSAILEQSMQIVLCNAHNVLNKRGIMT---SYQM---KMAPQVTAK 1814
            .|.:||:.  .|:..|.:|.                      |:.|   .||.   .|...|:.|
Human  1414 ENAVDVFQ--VAKMINLMRP----------------------GVFTDIEQYQFIYKAMLSLVSTK 1454

  Fly  1815 EQ---------------QENKDPLNELDAL 1829
            |.               .:..||...:::|
Human  1455 ENGNGPMTVDKNGAVLIADESDPAESMESL 1484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747	9/44 (20%)
		ALIX_LYPXL_bnd	421..699	CDD:290660	9/41 (22%)
		Med15	808..>1246	CDD:255446	96/553 (17%)
		Y_phosphatase	1558..1788	CDD:278528	63/246 (26%)
		PTPc	1559..1745	CDD:238006	55/202 (27%)
PTPRG	XP_016862450.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900