DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and PTPN12

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_002826.3	Gene:	PTPN12 / 5782	HGNCID:	9645	Length:	780	Species:	Homo sapiens

Alignment Length:	380	Identity:	77/380 - (20%)
Similarity:	139/380 - (36%)	Gaps:	109/380 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1506 KEVESYEKLLENLHVKML---NGKTQLGAKWQELQ--------QKLDKEAAANKRSTTIAKLFPE 1559
            ::||...|.::.:.....   ||:......:..|:        :|:...|...|....      :
Human     2 EQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENV------K 60

  Fly  1560 KNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSE 1620
            |||..|.||:||:||||    ..|..|||||.::|.: .|...::..|.|..||:.|||.|||..
Human    61 KNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGV-YGPKAYVATQGPLANTVIDFWRMIWEY 124

  Fly  1621 KSRTVVCLHTPNEL----FDPYWPQALDQPTHYDDYTVTC----------LKVQQLSHCSEYQLK 1671
            ....:|......|:    .:.|||...:.|..:..:.::|          ::...|...:|.:..
Human   125 NVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRL 189

  Fly  1672 LSMH-----------GADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCKAANAPQSPLI 1725
            ...|           ..|::||:..|..|                 .:.|.         ..|:.
Human   190 YQFHYVNWPDHDVPSSFDSILDMISLMRK-----------------YQEHE---------DVPIC 228

  Fly  1726 MNCLTGSERSELVAIGVCAIIATQN-----KQPILLNTIDVWSRICAQRQNSLRD---------- 1775
            ::|..|..|:.    .:|||..|.|     |.|...|..::...:..||.::::.
Human   229 IHCSAGCGRTG----AICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRA 289

  Fly  1776 -SAILEQSMQIV-------LCNAHNVLNKRGIMTSYQMKMAPQVTAKEQQENKDP 1822
             :.:.|:.:|:.       :.:..|.:|...:::|.:         .|:|::..|
Human   290 IAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIE---------PEKQDSPPP 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446
		Y_phosphatase	1558..1788	CDD:278528	62/281 (22%)
		PTPc	1559..1745	CDD:238006	51/214 (24%)
PTPN12	NP_002826.3	PTPc	28..292	CDD:214550	64/300 (21%)
		PTPc	60..292	CDD:238006	60/262 (23%)
		Substrate binding. /evidence=ECO:0000305\|PubMed:27134172	63..67		1/3 (33%)
		Substrate binding. /evidence=ECO:0000250	231..237		2/5 (40%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	345..438
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..639
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..725
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..780
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810