DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and ptpn5

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_009301648.1	Gene:	ptpn5 / 559524	ZFINID:	ZDB-GENE-101028-3	Length:	529	Species:	Danio rerio

Alignment Length:	479	Identity:	105/479 - (21%)
Similarity:	172/479 - (35%)	Gaps:	113/479 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1405 KVESVAEHAAPATAEIPVAATEGTAQTPVTIPSGPKCASLDNLSNCSDLSSLENFDW-------- 1461
            :|||:....|.....:.:..|.........:|....|...|...:.|...|....:|
Zfish   106 RVESLLPLIATLFLGVVILGTGTLFCIKTLVPGNQSCFPEDRRQSMSRQPSFTYSEWTDAKQEDF 170

  Fly  1462 ---DSVSVT---HSVSEKQTKASATA---------NGHSSSFAFQSETFTDEKTTKY-------- 1503
               |:|..|   ....:.:|:|....         ....|:.:...:..|...|..|
Zfish   171 YELDAVPETPVFDCFMDMKTEADPVTLTVKPVGLQERRGSNVSLTLDMCTPGTTEPYGALLSPRE 235

  Fly  1504 --FQKEVESYEKLL--ENLHVKMLNGKTQLGAKWQELQQKLDKEAAANKRSTTIAKLFPEKNRSL 1564
              .|:.:::...||  |.||.:.|:... |.|::.|.....     .:.:..:|..:. .|||..
Zfish   236 QSTQEYLQNASNLLTPEQLHTRALDDGV-LQAEFYETPMNF-----VDPKEYSIPGVV-RKNRYK 293

  Fly  1565 DCLPYDHARVKLD-KQTDD----YINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRT 1624
            ..||..|:||.|. |:..|    ||||.|:|........:|..|.|..||:.|||.|:|.|:...
Zfish   294 TILPNTHSRVCLKAKEEGDFLSTYINANYLKGYGGKEKAYIATQGPTVNTVGDFWRMVWQERCPI 358

  Fly  1625 VVC---LHTPNELFDPYWPQALDQPTHYDDYTVTC----LKVQQLSHCSEYQLKLSMHGADAVLD 1682
            :|.   :...||....|||:.          :|||    :.|:|:....:|.|::....::.. :
Zfish   359 IVMITNIEEKNEKCTEYWPED----------SVTCEGIEITVKQVIQADDYSLRIFTVKSEGE-E 412

  Fly  1683 LSLLQLKQWTKGAPAQ--------LLGVAENALETHRQRCKAANAP--QSPLIMNCLTGSERSEL 1737
            .||.|  .|....|.|        ||.:.:...|..:|      ||  ..|:|::|..|..|:.
Zfish   413 RSLRQ--YWYTSWPDQKTPDKAPPLLELVQEVEEARKQ------APPNSGPVIVHCSAGIGRTG- 468

  Fly  1738 VAIGVCAIIATQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLCNAHNVLNKRG-IMT 1801
                  ..|||              |.:|.|..|        |..:.|:...:...|::.| |.|
Zfish   469 ------CFIAT--------------SILCQQLSN--------EGVVDILKTTSQLRLDRGGMIQT 505

  Fly  1802 SYQMKMAPQVTAKEQQENKDPLNE 1825
            :.|.:....|.:..:::.::...|
Zfish   506 AEQYQFVHHVLSLYERQLRETSEE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446
		Y_phosphatase	1558..1788	CDD:278528	67/251 (27%)
		PTPc	1559..1745	CDD:238006	58/207 (28%)
ptpn5	XP_009301648.1	PTPc	264..516	CDD:214550	76/305 (25%)
ptpn5	XP_009301648.1	PTPc	289..516	CDD:238006	72/274 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900