Protein Alignment mop and Rhpn2

DIOPT Version :9

• Sequence 1: NP_648722.2
• Gene: mop / 39610
• FlyBaseID: FBgn0036448
• Length: 1833
• Species: Drosophila melanogaster
• Sequence 2: NP_082173.3
• Gene: Rhpn2 / 52428
• MGIID: 1289234
• Length: 686
• Species: Mus musculus
• Alignment Length: 586
• Identity: 119/586 - (20%)
• Similarity: 207/586 - (35%)
• Gaps: 144/586 - (24%)

  Fly    14 LKSSPEGTSFAALKKYIAEFYHEDPEAYSKEVHALETLRNQAMHTTKD--GAPVMKRYYCQLHAL 76
            ||.:.|.......|.:|.|.|.||...|..::..|..||......::|  |..::..|:.||..:
Mouse   117 LKETKEVDFSIVFKDFILEHYSEDSYLYEDDIADLMDLRQACRTPSRDEAGVELLMSYFIQLGFV 181

  Fly    77 QNR-FPQLADRGIFTFKWKDLYHSAVHEVTDLRFERAAVLFNIAALHTQSGASVTRGDVDGMKMA 140
            ::| ||.....|:. |.|.|.:.........|..|:|:|||||.||:||.|....|....|::.|
Mouse   182 ESRFFPPTRHMGLL-FTWYDSFTGVPVSQQTLLLEKASVLFNIGALYTQIGTRCNRQTQAGLESA 245

  Fly   141 CTHFQAAAWAYGELRERYANVNGGGDFMTPELLVFQQQVCFAQAQECILEKSLIDNRKPHI---- 201
            ...||.||.....|:|.:.:.....  |:|.:|....::..|||||.:.||..:    |.|
Mouse   246 VDAFQRAAGVLNYLKETFTHTPSYD--MSPAMLSVLVKMMLAQAQESVFEKVCL----PGIQNEF 304

  Fly   202 -----VAKVTAQIVVYYGAALAALLTGGDDGPVAQVIDSSVYKLWKKYVRFKINYLTCILYLYQG 261
                 ||:..|::...|....||:    ...||.:.|..|    |......|..:...:.:.:..
Mouse   305 FVLVKVAQEAAKVAEAYRQLHAAM----SQEPVKENIPYS----WASVAYVKAYHYGALAHYFAA 361

  Fly   262 --------------QHSEE------------------KRQMGERVTLYQASWDKL----EEARKE 290
                          .|.|:                  .:..|:||.|.:....:.    ||:.:|
Mouse   362 TLLIDHQLKPGADEDHQEKCLSQLYDRMPEGMTPLATLKNAGQRVLLGKGHLHRAIGFHEESLRE 426

  Fly   291 S---KGLPDQREINESLSFTADVVEAKRKNAKNENEFI--------------------------- 325
            :   |.|.|.:.:.:.||......:.|....:.:::.:
Mouse   427 ANLCKKLRDIQVLRDVLSAAHQRTQLKHTQHREDDDLLNLIDAPDVLPKTEREVKITFPDFSKVT 491

  Fly   326 ---YHEAVPELSTIAAVQGANLVNGIGFQVSD------------------EEH-----AGPDIFA 364
               :.:.:..||..:|.:..:...||.|.|.:                  :.|     ||.....
Mouse   492 VTDFFQKLGPLSVFSASKRWSPPRGIHFTVEEGDLGFTLRGNTPVQVHFLDPHCSASLAGAKEGD 556

  Fly   365 RLVPMKAHEASSLYSEEKAKLLRKYGALLEEKDTQLESYMSSLTLDNLNINEEQANKLPQGIVDR 429
            .:|.::..:...|...|..|||:.:|.  ||.:.::.|.:.|.:                .:.::
Mouse   557 YIVSIQGVDCKWLTVSEVMKLLKSFGG--EEVEMKVVSLLDSTS----------------SMHNK 603

  Fly   430 CAALNANKTAISDLVEAMSQLAEITADVETNLGEISSMLEAEAKAEREFQSAT------GVQRTP 488
            ||..:........:: .:|...:..||....:.:..|.|.......|:..::|      |:.|:.
Mouse   604 CATYSVGMQKTYSMI-CLSMDDDDKADKTKKISKKLSFLSWGTSKNRQKSASTLCLPEVGLARSQ 667

  Fly   489 N 489
            |
Mouse   668 N 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762	96/452 (21%)
		V_HD-PTP_like	368..702	CDD:185747	22/128 (17%)
		ALIX_LYPXL_bnd	421..699	CDD:290660	12/75 (16%)
		Med15	808..>1246	CDD:255446
		Y_phosphatase	1558..1788	CDD:278528
		PTPc	1559..1745	CDD:238006
Rhpn2	NP_082173.3	HR1_Rhophilin-2	27..108	CDD:212024
		Interaction with Rho. /evidence=ECO:0000250	46..66
		BRO1_Rhophilin_2	112..496	CDD:185772	86/393 (22%)
		PDZ_signaling	522..591	CDD:238492	12/70 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810