DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mop and ptprz1a

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_005163194.1	Gene:	ptprz1a / 497461	ZFINID:	ZDB-GENE-090406-1	Length:	1827	Species:	Danio rerio

Alignment Length:	1699	Identity:	309/1699 - (18%)
Similarity:	532/1699 - (31%)	Gaps:	562/1699 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   497 REFQKYSE----AHARAGESNNTLRKAMSLH------VNNLKILARPLPEIQQLMPK--LSSELN 549
            |..:|.||    ::|.....||..:|..|.:      :|..:.||:...:.|:|..:  |....:
Zfish    30 RSQKKLSENVEWSYAGTLNQNNWAKKYPSCNNAKQSPINVEESLAQVKIQFQKLRLEGWLEKTSD 94

  Fly   550 TTEIFRDVKLILNKV------------NEMKAQRAQFH---------------------ADLRIA 581
            :|.:..|.|.:...|            ::.|..|..||                     .:::|.
Zfish    95 STTVKNDGKTVAIDVGGEFYVSGGGLRSKFKVGRISFHWGLCNASSDGSEHGLNGEKYPLEMQIY 159

  Fly   582 INEDDI---TGKVIAHGGQ-EGLQALFATELGKHDKITELLDQ-NMVA-------------QGNI 628
            ..|.|:   ..:....||: ..|..||.|....:...|.::|. |.|:             || :
Zfish   160 CYEADVFSDLDEAFREGGKITALAVLFETSTEDNVNYTAIIDAVNSVSRYGKSGSISPFTMQG-L 223

  Fly   629 LQALTENY------AKAAPVLKTLQDVKQKREHFYSSLAASYDVYEDLLAKSAKGLEFYKKL--- 684
            |.:.||.|      ....|..:|::                :.|:::.:|.|...||.:.::
Zfish   224 LPSSTEKYFIYNGSLTTPPCSETVE----------------WIVFKNTVAISDVQLEMFCEVMTM 272

  Fly   685 --AGNV---QKLLTRFRSARDVQSEERQQRMQSVKAATTPV--VSKPIAETTPVPAVSSTPKLRD 742
              .|.|   ..|...:|:       :::|.|..|.::.|.|  |..||..:.|....:|......
Zfish   273 QQVGYVMLMDYLQNNYRN-------QQEQFMGQVFSSYTGVEEVHTPICSSEPENVQASPHNYTS 330

  Fly   743 YL---KAKAAMADASNPAYVPTVRPVPVGSENPTQAACSYATAPPNEPPPPYS--LTQQQYFDPS 802
            .|   :...|:.|:|...|..|.||    ::...::|..|.|....:......  :....|....
Zfish   331 MLVIWERPRAVYDSSIERYSVTYRP----AQGDDESALEYLTDGDQDVGAIIQDLVANTSYMVQV 391

  Fly   803 AAGYTNPMYQQQQQHIAPPAYKAQASPNSQTLHGALGQMNLQGQSQDNNQAGMAY----NYGY-- 861
            .|..||.:|.:....:..                   .:.|.....||:.....|    ||..
Zfish   392 VAVCTNGLYGRVSDQLTV-------------------DVPLDDPEADNDSESFDYDEEENYHINP 437

  Fly   862 ----PSGSVPPLAYAPPGTVPASSASQGLNIQQPLYVATSGN-----PVSVSNP----------- 906
                |.....|..:....|.|..:.::  .:..|:...|...     ||..|..
Zfish   438 FLIRPETERLPYPFQTTTTSPRVTTTE--RLIHPVVKTTQRTHERRLPVEESQKTHDDIFPVVYT 500

  Fly   907 -------SELPSTLQAPFVVN---PMSNPYQTAAGYSGQAYQQVNAQAQQVTYPTAPSGSSTGQS 961
                   ::.|:|:...|||:   ...:.::..||.|.:      :..|..::..:|: |.|.::
Zfish   501 DKPTAKHTDQPTTITTTFVVDVHTTTPDSFRFIAGVSSE------SDVQSSSFTDSPT-SVTPET 558

  Fly   962 AQQPLGYAPSQG-----------PQQQAGGYPQSQTPQQQVGAYQQQPLSGYAQQLTPQQQTGYS 1015
            ::....:..|..           |......:.:|                              |
Zfish   559 SETLERFVTSASIDILEVEDVTEPVTITDSFEES------------------------------S 593

  Fly  1016 QSQAPQLQAPSYAQNQQSTGQAQQQQTGYPQTPQQHLAGYAQSQQQATGYPQSQTSQQQTTGYSQ 1080
            |:.||.|:.|  ..:..||..::...  :|.|........|     |.....|||:|....|.|.
Zfish   594 QTVAPLLEIP--VDSTSSTFPSEVPL--WPTTASLPFPATA-----AFSTVLSQTTQPVFNGESA 649

  Fly  1081 SQTP--QQPLAYQQQPSGYPQQQQQQSLAPQQPSLYPSQAVQASPQP---IP---------GQQA 1131
            ...|  ...|:|..             .:|..|  |...:|.:.|.|   ||         |.|:
Zfish   650 PYAPSVSDTLSYVH-------------ASPVSP--YSLSSVLSEPIPDWDIPYTVTMLVSGGAQS 699

  Fly  1132 TPPNAGQP---LPYPQQYTDPNAA-----------PAPAPGVSSVPSPVPVPTPAPTSSQAQV-- 1180
            ..|:...|   |.....|.|..:.           .|...|.:|...|.....|..|.|:...
Zfish   700 ITPSPSYPTLSLSGSVSYLDMESVSSGGCIDDDGDDAVLSGSASADPPCRTTLPLQTLSEVTASV 764

  Fly  1181 -PTSPHPSATYTSYSNHPGYSFNPQTGKY-----EYSSGYQQDTSSLKGSQASQSYQFSQSGKQQ 1239
             |..|...::....|.|.|......|..|     ..|..|...|::|.    :.:.....:|:..
Zfish   765 DPMLPSSESSLLHLSEHSGTISVLSTPAYLQPSVPVSKDYSTTTTTLD----TDASLLGSNGESN 825

  Fly  1240 SVGTTDSEIASRSNTATGFDSPIVSHTKVNMAAKDSTSAIEGNESSNYYSTPYGYLGSVNPQQQP 1304
            .:    :|....|..|..|.|....|...|.....|.|.:
Zfish   826 LL----TEWVDSSLAAPTFSSKFSLHASSNSLLPSSVSGL------------------------- 861

  Fly  1305 TPAPPSNSTAS----IYMQSGASSTAETQTTSSGVPYASSAAL--TKVEPKPEA-LPPKVTSNVD 1362
               ||.:|..|    :::....||.:.:..:.:|:..::.|.|  ..:..||.: |...|.:.|:
Zfish   862 ---PPCSSLLSNPVELHLFQSTSSASTSLCSDAGLDLSTKALLPSLSISTKPSSDLSLSVAATVN 923

  Fly  1363 LLSDLDIDCSVAVPPPM---------------LPQPVLQPQVVATPTPPASQVSV--PVKVESVA 1410
            .::...|..|:....|:               .|.||:.|.:  .||.|:..::|  ||...::.
Zfish   924 NIAQSAIGQSLGASAPIRSSAITTTPILELRSTPTPVVPPTI--APTSPSDSITVVAPVVPPTIP 986

  Fly  1411 EHAAPATAEIPVAATEGTAQTPVT-----IPSGPKCASLDNLSNCSDLSSLENFDWDSVSVTHSV 1470
            ..:||.::.:|..:.:|..:...:     :..|...||.|                :|::..:..
Zfish   987 VSSAPESSSMPTHSADGQQENSASGWTFDLDWGQSSASGD----------------ESIAAPYIT 1035

  Fly  1471 SEKQTKAS--ATANG---HSSSFAFQ----------------------------------SETFT 1496
            :...|:.|  .|.:|   |||||.|:                                  .||.|
Zfish  1036 TASPTEVSPEETDDGNEEHSSSFYFEGENGTESEVTDFRVTLQPSPSWTLRGSWEEESGSGETLT 1100

  Fly  1497 DEKTTKYF----QKEVESYEKLLENL--------------------------------------- 1518
            |.:|:..|    :.|.||.|:.:|:.
Zfish  1101 DNETSSDFSIPERTERESEEEPVEDANNSSHESRVGLASSIERQKKAVVPLAVVSTLTFLGLIFL 1165

  Fly  1519 -------------------------------------------------HVKMLNGKTQLGAKWQ 1534
                                                             ||..|:..:....:::
Zfish  1166 IGIYIYWRKCFQTAHFYIEDSTSPRVISSLPLLNPTGEHEPLPVKQFVNHVTELHNTSSFSREFE 1230

  Fly  1535 ELQQKLD--KEAAANKRSTTIAKLFPE---KNRSLDCLPYDHARVKL-------DKQTDDYINAA 1587
            .|::..:  :....:..:||.....|:   |||.::.|.|||:||:|       .|...|||||.
Zfish  1231 ILKEYFEEVQTCTVDLGTTTDCSNHPDNKNKNRYVNILAYDHSRVRLAPLNDKDGKSGGDYINAN 1295

  Fly  1588 YM----KNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCL----HTPNELFDPYWPQALD 1644
            |:    ||.:     :|.||.|..::..|||.|:|.:....:|.:    ....:..|.|||  |:
Zfish  1296 YVDGFNKNKA-----YIAAQGPLKSSTPDFWRMVWEQNVGVIVMITNLVEKGRKKCDQYWP--LE 1353

  Fly  1645 QPTHYDDYTVTCLKVQQLSHCSEYQLKL--------SMHGADAVLDLSLLQLKQW-TKGAPAQLL 1700
            ....|..:.||......|::.::....|        |.........::.....|| ..|.|..:|
Zfish  1354 NREEYGCFLVTVKSTNVLAYYTKRTFTLRNTSIKKGSQRYRSNERTVTQYHYTQWPDMGVPEYVL 1418

  Fly  1701 GVAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVAIGVCAIIATQNKQPILLNTIDVW--- 1762
            .|    |....:..||......|::::|..|..|:     |...::.:..||.....|:::.
Zfish  1419 PV----LSFVYKSSKAQTDGMGPMVVHCSAGVGRT-----GTYIVLDSMLKQIKEKGTVNIMGFL 1474

  Fly  1763 SRICAQRQNSLRD------------SAILEQSMQIVLCNAHNVLNKRGIMT---------SYQMK 1806
            ..|..||...::.            .|||.|..::...:.|..:|  .::|         ..|.|
Zfish  1475 KHIRTQRNYLVQTEEQYIFTHDALVEAILSQETEVSSSHIHQYVN--NLLTPGASCKTRLEKQFK 1537

  Fly  1807 MAPQVTAKE 1815
            :..|..||:
Zfish  1538 LVCQSNAKQ 1546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747	53/281 (19%)
		ALIX_LYPXL_bnd	421..699	CDD:290660	53/278 (19%)
		Med15	808..>1246	CDD:255446	87/520 (17%)
		Y_phosphatase	1558..1788	CDD:278528	65/271 (24%)
		PTPc	1559..1745	CDD:238006	54/212 (25%)
ptprz1a	XP_005163194.1	alpha_CARP_receptor_like	48..301	CDD:239396	51/276 (18%)
		fn3	316..398	CDD:278470	16/85 (19%)
		PTPc	1225..1500	CDD:214550	64/290 (22%)
		PTPc	1261..1500	CDD:238006	60/254 (24%)
		PTPc	1532..1791	CDD:214550	5/15 (33%)
		PTPc	1559..1791	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000