DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mop and pdcd6ip

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_012809018.2	Gene:	pdcd6ip / 496474	XenbaseID:	XB-GENE-1194420	Length:	875	Species:	Xenopus tropicalis

Alignment Length:	1074	Identity:	252/1074 - (23%)
Similarity:	423/1074 - (39%)	Gaps:	279/1074 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LKSSPEGTSFAALKKYIAEFY--HEDPEAYSKEVHALETLRNQAMHTTKDGAPVMK--------- 67
            ||.:.|......|.|||...|  .||...|.:.|..|..||..|:     |.|:.|
Frog     9 LKKTSEVDLVKPLSKYIHNTYPSGEDQTEYCRAVEELNKLRKSAV-----GRPLDKHETSLETVM 68

  Fly    68 RYYCQLHALQNRFPQLADRGIFTFKWKDLYH-------SAVHEVTDLRFERAAVLFNIAALHTQS 125
            |||.||.:::.:||....:...||.|||.:.       |....:..|.:|:..|||||.||.:|.
Frog    69 RYYDQLCSVEPKFPFTESQLCLTFTWKDAFDKGSIFGGSVKLALPSLGYEKTCVLFNIGALASQI 133

  Fly   126 GASVTRGDVDGMKMACTHFQAAAWAYGELRE-------RYANVNGGGDFMTPELLVFQQQVCFAQ 183
            .:.....:.:.:|.|...:|.|:.|:..:::       |...|:     ::|:.:.....:..||
Frog   134 ASEQNLDNDEALKAASKFYQLASGAFSHIKDTVLSSLNRDPTVD-----ISPDTVGTLSLIMLAQ 193

  Fly   184 AQECILEKSLIDNRKPHIVAKVTAQIVVYYGAALAALLTGGDDGPVAQVIDSSVYK-LWKKYVRF 247
            |||....|:..|..|..::||:..|...|||.|                .....|| ...||..|
Frog   194 AQEVFFLKATRDKMKDALIAKLANQAADYYGDA----------------FKQCQYKDTLSKYFYF 242

  Fly   248 K-----INYLTCILYLYQGQH----SEEKRQMGERVTLYQASWD--KLEEARKES----KGLPDQ 297
            :     :....||:..:...|    ::::::.||.:...|.:.|  |...:|.:.    |.|.|
Frog   243 QEVFPILAAKHCIMQAHAAYHQSVLAKQQKKFGEEIGRLQHASDLVKTVSSRYDEYVNVKDLAD- 306

  Fly   298 REINESLSFTADVVEAKRKNAKNENEFIYHEAVPELSTIAAVQGANLVNGIGFQVS-DEEHAGPD 361
             :||.:|  ||         ||.:|:||||:.||:|..:..:..|:||......|. .:::.  |
Frog   307 -KINRAL--TA---------AKKDNDFIYHDRVPDLKDLDPIGKASLVKPTPINVPLSQKYT--D 357

  Fly   362 IFARLVPMKAHEASSLYSEEKAKLLRKYGALLEEKDTQLESYMSSLTLDNLNINEEQANKLPQGI 426
            :|.::||:...:..::|::.:|:|:....|.:.:..|.....::||.|. ..|.:...:.:||.|
Frog   358 LFEKMVPLAIQQCLTVYNQRRAELINATIAQMRDATTFANGVLASLNLP-AAIEDVSGDSVPQSI 421

  Fly   427 VDRCAALNANKTAIS------------DLVEAMSQLAEITADVETNLGEISSMLEAEAKAEREFQ 479
                  ||.:||.|.            ||.|.:.:..||       |.|....|:.|...:.:.:
Frog   422 ------LNKSKTIIEQGGIQTIDQLIRDLPELLQRNKEI-------LDESVKFLDEEEATDNDLK 473

  Fly   480 S--ATGVQRTPNAHITE-LSREFQKYSEAHARAGESNNTLRKAMSLHVNNLKILARPLPEIQQLM 541
            :  ....||||:..:.: |..|...:.....:|..::..:::....|...:.||.:|..|:...:
Frog   474 AKFKDRWQRTPSTELYKPLRSEGNNFRSVLDKAIGADAVVKERYQCHREAIAILCKPEAELNAAI 538

  Fly   542 PKL--SSELNTTEIFRDVKLILNKVNEMKAQRAQFHADLRIAINEDDITGKVIAHGGQEGL---Q 601
            |..  :..:..:|:...:|.:||:::::|..|.|...|:: ::| .|:|.|.:....|:|.   :
Frog   539 PSANPAKTMQGSEVVSVLKSLLNQLDDVKKVREQLETDIK-SVN-FDMTTKFLTALAQDGAVNEE 601

  Fly   602 ALFATELGK-HDKITELLDQNMVAQG---NILQALTENYAKAAPVLKTLQDVKQKREHFYSSLAA 662
            |:..|||.: :...|..:.:|:..|.   |.:|...:.::|    :|........||....:|||
Frog   602 AISVTELDRIYGSYTFKVQENLKKQEDLINNIQTAHQEFSK----MKQSNSEANLREEVLKNLAA 662

  Fly   663 SYDVYEDLLAKSAKGLEFYKKLAGNVQKLLTRFR-SARDVQSEERQQRMQSVKAATTPVVSKPIA 726
            .:|.|.:|:|...:|.:||..|.    ::|.::: ...|:....:.:|.:.:|.....:..:|.|
Frog   663 GHDNYIELVANLKEGTKFYNDLT----EILLKYQCKCSDIVFARKTERDELLKDLQQSIAREPSA 723

  Fly   727 ETTPVPAVSSTPKLRDYLKAKAAMADASNPAYVPTVRPVPVGSENPTQAACSYATAPPNEPPPPY 791
                    .|.|::..|..|.::.:..::.:.:||  |.|       :.....|..||..||||.
Frog   724 --------PSIPQVPSYQSASSSSSTNTSVSSIPT--PAP-------RTVFQSAKQPPPRPPPPT 771

  Fly   792 SLTQQQYFDPSAAGYTNPMYQQQQQHIAPPAYKAQASPNSQTLHGALGQMNLQGQSQDNNQAGMA 856
            .        |||    :|:          ||..||| ||
Frog   772 M--------PSA----SPV----------PASAAQA-PN-------------------------- 787

  Fly   857 YNYGYPSGSVPPLAYAPPGTVPASSASQGLNIQQPLYVATSGNPVSVSNPSELPSTLQAPFVVNP 921
                 |:          |.|.||:.:||.|:                   :.:||..|.|
Frog   788 -----PA----------PTTAPATDSSQPLS-------------------NTIPSQAQGP----- 813

  Fly   922 MSNPYQTAAGYSGQAYQQVNAQAQQVTYPTAPSGSSTGQSAQQPLGYAPSQGPQQQAGGYPQSQT 986
               ||.|..||.|              |...|          .|:||.|          |...
Frog   814 ---PYPTYPGYPG--------------YYGMP----------MPVGYNP----------YMYG-- 839

  Fly   987 PQQQVGAYQQQPLSGYAQQLTPQQQTGYSQSQAP 1020
             ||.:..|..||.||.|..  |.|.:.:|..|.|
Frog   840 -QQTIPPYMYQPPSGQAPY--PTQHSAFSYPQQP 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762	102/390 (26%)
		V_HD-PTP_like	368..702	CDD:185747	80/358 (22%)
		ALIX_LYPXL_bnd	421..699	CDD:290660	69/302 (23%)
		Med15	808..>1246	CDD:255446	46/213 (22%)
		Y_phosphatase	1558..1788	CDD:278528
		PTPc	1559..1745	CDD:238006
pdcd6ip	XP_012809018.2	BRO1_Alix	2..349	CDD:185763	100/378 (26%)
pdcd6ip	XP_012809018.2	V_Alix	364..702	CDD:185748	80/361 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D498845at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R147
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950