DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and Ptpn20

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_001073618.1	Gene:	Ptpn20 / 306281	RGDID:	1309812	Length:	421	Species:	Rattus norvegicus

Alignment Length:	453	Identity:	100/453 - (22%)
Similarity:	176/453 - (38%)	Gaps:	119/453 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1395 PPASQVSVPVKVESVAEHAAPATAEIPVAATEGTAQTPVTIPSGPKCASLDNLSNCSDL------ 1453
            |.:||...|.|               ||...:..:::       .|.:...:.||..||
  Rat    32 PSSSQQKTPTK---------------PVFGNKVNSES-------VKTSHHMSFSNKYDLVFPEPV 74

  Fly  1454 -SSLENFDWDSVSVTH-----SVSEKQTKASATANGHSSSFAFQSETFTDEKTTKYFQKEVESYE 1512
             |..:...||...::|     ||..:....|.|.:      ...||:.||   |...::|:..
  Rat    75 ESDNDETLWDVRDLSHRNRWSSVDPESAGPSKTVS------TVLSESSTD---TAVSERELTQ-- 128

  Fly  1513 KLLENLHVKMLNGKTQLGAK--WQELQQKLDKEAAANKRSTTIAKLFP-------------EKNR 1562
              |..:...:.|..::...:  .:.||:|  :|....:....:.::.|             :|||
  Rat   129 --LAQIRPLIFNSSSRAALRDCLKALQKK--EELDIIREFLELEEMIPPDDFKSGYELQNRDKNR 189

  Fly  1563 SLDCLPYDHARVKLDKQTDDYINAAYMKNLSAGCPNFIVA-QTPQPNTINDFWSMIWSEKSRTVV 1626
            ..|.||||..||.|.| ..|||||:|::.::.....|.:| |.|.|:||.|||.|: .|.:..|:
  Rat   190 YRDILPYDSTRVPLGK-NKDYINASYIRIVNHEEEYFYIATQGPLPDTIEDFWQMV-LENNCNVI 252

  Fly  1627 CLHTPNELFD------PYWPQALDQPTHY-------DDYTVT---CLKVQQL-------SHCSEY 1668
            .:.| .|:..      .|||.:|.:|..:       :::.:|   .:::.|:       ||..::
  Rat   253 AMIT-REIEGGVIKCCSYWPVSLKEPLEFKHFHVLLENFQITQYFVIRIFQIVKKSTGKSHSVKH 316

  Fly  1669 Q--LKLSMHGADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCKAANAPQSPLIMNCLTG 1731
            .  :|...||..|..|..:..::...|   :.:.|                     ||:::|..|
  Rat   317 LQFIKWPDHGTPASADFFIKYVRYVRK---SHITG---------------------PLLVHCSAG 357

  Fly  1732 SERSELVAIGVCAIIATQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLCNAHNVL 1794
            ..|:. |.|.|..:..|..|. ...|.:::.:::..||...::.....:...:|||....|:|
  Rat   358 VGRTG-VFICVDVVFCTIEKN-YSFNIMNIVTQMRKQRFGMIQTKEQYQFCYEIVLEVLQNLL 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446
		Y_phosphatase	1558..1788	CDD:278528	65/268 (24%)
		PTPc	1559..1745	CDD:238006	57/211 (27%)
Ptpn20	NP_001073618.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		8/47 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..116		6/28 (21%)
		PTPc	160..412	CDD:214550	65/280 (23%)
		PTPc	186..412	CDD:238006	64/254 (25%)
		Substrate binding. /evidence=ECO:0000250	354..360		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900