DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mop and Ptpn5

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_038965611.1	Gene:	Ptpn5 / 29644	RGDID:	3448	Length:	613	Species:	Rattus norvegicus

Alignment Length:	820	Identity:	161/820 - (19%)
Similarity:	267/820 - (32%)	Gaps:	279/820 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1052 LAGYAQSQQQATGYPQSQTSQQQTTGYSQSQ-------TPQQPLAYQQQPSGYPQQQQQQSLAPQ 1109
            |:..:.|..:.:|...:|.|::::.....|:       ..::.|.:|..|....|...|..|..:
  Rat     9 LSSSSSSLTKESGDRMAQWSEKESQAADDSKGGTLDMCCSKRLLGWQHGPPVGDQIPGQDKLLSK 73

  Fly  1110 QPSLYPSQAVQASPQPIPGQQATPPNAGQPLPYPQQYTDPNAAPAPAPGVSSVPSPVPVPTPAPT 1174
            :.|...|:.:   |||:   :....:.|:.||..|:                   .:|.|.|:|.
  Rat    74 KRSTEDSKGL---PQPV---EMGGLDEGEGLPSKQR-------------------ELPPPPPSPP 113

  Fly  1175 SSQAQVPTSPHPSATYTSYSNHPGYSFNPQTGKYEYSSGYQQDTSSLKGSQ---ASQSYQFSQSG 1236
            |..||                    ...|| |...:|...:........||   |......|..|
  Rat   114 SEPAQ--------------------KLPPQ-GAGSHSLTVRSSLCLFAASQLLLACGVLWLSGHG 157

  Fly  1237 KQQSVGTTDSEIASRSNTATGFDSPIVSHTKVNMAAKDSTSAIEGNESSNYYSTPYGYLGSV--- 1298
            ......|||...:|.:         :::|.        ..:|..|   |..:.||...|.|:
  Rat   158 HSWLQTTTDLIFSSLT---------VLNHL--------GPAAWLG---SGTWGTPSLLLVSLTVS 202

  Fly  1299 -------------NPQQQPTPAPPSNSTASIYMQSGASSTAETQTTSSGVPYASSAALTKVEPKP 1350
                         .|.:.|.|.||.:...|:..|...:.:
  Rat   203 LGIITTLVWHLLKTPPEPPVPLPPEDRRQSVSRQPSFTYS------------------------- 242

  Fly  1351 EALPPKVTSNVDLLSDLDIDCSVAVPPPMLPQPVLQPQVVATPTPPASQVSVPVKVESVAEHAAP 1415
            |.:..||..:.     ||:|                    |.|..|.....:.:|.|     |.|
  Rat   243 EWMEEKVEDDF-----LDLD--------------------AVPETPVFDCVMDIKPE-----ADP 277

  Fly  1416 ATAEIPVAATEGTAQTPVTIPSGPKCASLDNLSNCSDLSSLENFDWDSVSVTHSVSEKQTKASAT 1480
                           |.:|:.|                ..|:.....:||:|..:        .|
  Rat   278 ---------------TSLTVKS----------------MGLQERRGSNVSLTLDM--------CT 303

  Fly  1481 ANGHSSSFAFQSETFTDEKTTKYFQKEVESYEKLL--------ENLHVKMLNGKTQLGAKWQELQ 1537
            ...:...|.:...           .:|..::|.||        |.||.|.|: ...|.|::.|:.
  Rat   304 PGCNEEGFGYLVS-----------PREESAHEYLLSASRVLRAEELHEKALD-PFLLQAEFFEIP 356

  Fly  1538 QKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKL-----DKQTDDYINAAYMKNLSAGCP 1597
            ...     .:.:...|..|. .|||....||..|:||:|     :.....||||.|::..:....
  Rat   357 MNF-----VDPKEYDIPGLV-RKNRYKTILPNPHSRVRLTSPDPEDPLSSYINANYIRGYNGEEK 415

  Fly  1598 NFIVAQTPQPNTINDFWSMIWSEKSRTVVC---LHTPNELFDPYWPQALDQPTHYDDYTVTCLKV 1659
            .:|..|.|..:|:.|||.|:|.|::..:|.   :...||....|||:  :|..| |...:|   |
  Rat   416 VYIATQGPIVSTVADFWRMVWQERTPIIVMITNIEEMNEKCTEYWPE--EQVVH-DGVEIT---V 474

  Fly  1660 QQLSHCSEYQLKLSMHGADAVLDLSLLQ------LKQ-WTKGAPAQ-----------LLGVAENA 1706
            |::.|..:|:|:|          :||.:      ||. |....|.|           |:...|.|
  Rat   475 QKVIHTEDYRLRL----------ISLRRGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEA 529

  Fly  1707 LETHRQRCKAANAPQSPLIMNCLTGSERSE-LVAIGVCAIIATQNKQPILLNTIDVWSRICAQRQ 1770
            .:.....|       ||:|::|..|..|:. .:|..:|.      :|......:|:....|..||
  Rat   530 AQQEGPHC-------SPIIVHCSAGIGRTGCFIATSICC------QQLRREGVVDILKTTCQLRQ 581

  Fly  1771 NSLRDSAILEQSMQIVLCNAHNVLNKRGIMTSYQMKMAPQ 1810
                     ::...|..|..:..::.  .|:.|:.:::.|
  Rat   582 ---------DRGGMIQTCEQYQFVHH--AMSLYEKQLSLQ 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446	39/203 (19%)
		Y_phosphatase	1558..1788	CDD:278528	65/256 (25%)
		PTPc	1559..1745	CDD:238006	59/212 (28%)
Ptpn5	XP_038965611.1	PTPc-N5	346..603	CDD:350461	72/302 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900