DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and Ptpn22

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_001099930.1	Gene:	Ptpn22 / 295338	RGDID:	1307992	Length:	804	Species:	Rattus norvegicus

Alignment Length:	309	Identity:	75/309 - (24%)
Similarity:	138/309 - (44%)	Gaps:	31/309 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1505 QKEVESYEKLLENLHVKMLNGKTQLGAKWQELQQKLDKEAAANKRSTTIAKLFP---EKNRSLDC 1566
            |:|:  .::||:....|.:| :.:...::.:|:::..|..|.....||:|:. |   :|||..|.
  Rat     3 QREI--LQQLLKEAQKKKIN-REEFANEFLKLKRQSTKYKADKIYPTTVAQR-PKNIKKNRYKDI 63

  Fly  1567 LPYDHARVKLDKQTDD----YINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVV- 1626
            |||||:.|:|...|.|    ||||:::|.: .|...:|..|.|...|:.|||.|||..:...:|
  Rat    64 LPYDHSLVELSLLTSDEDSSYINASFIKGV-YGPRAYIATQGPLSTTLLDFWRMIWEYRVLVIVM 127

  Fly  1627 -CL--HTPNELFDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQL 1688
             |:  ....:..:.||.:..:....:..::::|...::.|......||...:....:  :.....
  Rat   128 ACMEFEMGKKKCERYWAEPGETQLQFGPFSISCETEKKKSDYKIRTLKAKFNSETRI--VYQFHY 190

  Fly  1689 KQW-TKGAPAQLLGVAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVAIGVCAIIATQN-- 1750
            |.| ....|:.:..:.:...:   .||...: ...||.::|..|..|:.:    :||:..|..
  Rat   191 KNWPDHDVPSSIDPILQLIWD---MRCYQED-DCVPLCIHCSAGCGRTGV----ICAVDYTWMLL 247

  Fly  1751 KQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLCNAHNVLNKRGI 1799
            |..|:.....|::.|  |...:.|.|.:..|....::.:|...|.||.:
  Rat   248 KDGIIPKNFSVFNLI--QEMRTQRPSLVQTQEQYELVYSAVLELFKRHV 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446
		Y_phosphatase	1558..1788	CDD:278528	59/243 (24%)
		PTPc	1559..1745	CDD:238006	48/194 (25%)
Ptpn22	NP_001099930.1	PTPc	24..288	CDD:214550	66/277 (24%)
Ptpn22	NP_001099930.1	PTPc	56..288	CDD:238006	59/244 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900