DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and PTPN22

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_057051.3	Gene:	PTPN22 / 26191	HGNCID:	9652	Length:	807	Species:	Homo sapiens

Alignment Length:	307	Identity:	78/307 - (25%)
Similarity:	133/307 - (43%)	Gaps:	31/307 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1505 QKEVESYEKLLENLHVKMLNGKTQLGAKWQELQQKLDKEAAANKRSTTIAKLFP---EKNRSLDC 1566
            |:|:  .:|.|:....|.:. |.:...::.:|:::..|..|.....||:|:. |   :|||..|.
Human     3 QREI--LQKFLDEAQSKKIT-KEEFANEFLKLKRQSTKYKADKTYPTTVAEK-PKNIKKNRYKDI 63

  Fly  1567 LPYDHARVKLDKQTDD----YINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVC 1627
            ||||::||:|...|.|    ||||.::|.: .|...:|..|.|...|:.|||.|||......:|.
Human    64 LPYDYSRVELSLITSDEDSSYINANFIKGV-YGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVM 127

  Fly  1628 LHTPNEL----FDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQL 1688
            .....|:    .:.||.:..:....:..::|:|...::.|......||:..:.....  :.....
Human   128 ACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRT--IYQFHY 190

  Fly  1689 KQW-TKGAPAQLLGVAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVAIGVCAIIATQN-- 1750
            |.| ....|:.:..:.|...:.   ||...: ...|:.::|..|..|:.:    :|||..|..
Human   191 KNWPDHDVPSSIDPILELIWDV---RCYQED-DSVPICIHCSAGCGRTGV----ICAIDYTWMLL 247

  Fly  1751 KQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLCNAHNVLNKR 1797
            |..|:.....|:|.|  :...:.|.|.:..|....::.||...|.||
Human   248 KDGIIPENFSVFSLI--REMRTQRPSLVQTQEQYELVYNAVLELFKR 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446
		Y_phosphatase	1558..1788	CDD:278528	61/243 (25%)
		PTPc	1559..1745	CDD:238006	49/194 (25%)
PTPN22	NP_057051.3	PTPc	24..288	CDD:214550	69/277 (25%)
		PTPc	56..288	CDD:238006	62/244 (25%)
		Substrate binding	227..233		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..700
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	724..746
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810