DRSC/TRiP Functional Genomics Resources

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Protein Alignment mop and PTPN23

DIOPT Version :10

Sequence 1:NP_648722.2 Gene:mop / 39610 FlyBaseID:FBgn0036448 Length:1833 Species:Drosophila melanogaster
Sequence 2:NP_056281.1 Gene:PTPN23 / 25930 HGNCID:14406 Length:1636 Species:Homo sapiens


Alignment Length:1899 Identity:535/1899 - (28%)
Similarity:788/1899 - (41%) Gaps:485/1899 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MEAVPRLHMLWFALKSSPEGTSFAALKKYIAEFYHEDPEAYSKEVHALETLRNQAMHTTKD--GA 63
            ||||||:.|:|..||.:.:.....|:||::.:.|.|:||||::|:..||.||..|:...:|  |.
Human     1 MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPRDFEGC 65

  Fly    64 PVMKRYYCQLHALQNRFPQ-LADRGIFTFKWKDLY--HSAVHEVTDLRFERAAVLFNIAALHTQS 125
            .|:::|..|||.||:|.|. ..........|.:::  .|..||  |:::|:|.:|:|:.|||:..
Human    66 SVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHE--DIKYEQACILYNLGALHSML 128

  Fly   126 GASVTRGDVDGMKMACTHFQAAAWAYGELRERYANVNGGGDFMTPELLVFQQQVCFAQAQECILE 190
            ||...|...:|||::|||||.||.|:..|||.:.......  |:.::|.....:...|||||:||
Human   129 GAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVD--MSRQILTLNVNLMLGQAQECLLE 191

  Fly   191 KSLIDNRKPHIVAKVTAQIVVYYGAALAALLTGGDDGPVAQVIDSSVYKLWKKYVRFKINYLTCI 255
            ||::||||..:||:::||:|.||..|..||     :.|....:...:.|.|||.|:.||.|...:
Human   192 KSMLDNRKSFLVARISAQVVDYYKEACRAL-----ENPDTASLLGRIQKDWKKLVQMKIYYFAAV 251

  Fly   256 LYLYQGQHSEEKRQMGERVTLYQASWDKLEEARKESKGLPDQREINESLSFTADVVEAKRKNAKN 320
            .:|:.|:.:||:::.||||..:|::.|||.||.|.:||.||  .:.::|.||.||:..|..:||.
Human   252 AHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPD--TVQDALRFTMDVIGGKYNSAKK 314

  Fly   321 ENEFIYHEAVPELSTIAAVQGANLVNGIGFQVSDEEHAGPDIFARLVPMKAHEASSLYSEEKAKL 385
            :|:||||||||.|.|:..|:||.||..:....:|....||||||:||||.|||||||||||||||
Human   315 DNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHEASSLYSEEKAKL 379

  Fly   386 LRKYGALLEEKDTQLESYMSSLTLDNLNI-NEEQANKLPQGIVDRCAALNANKTAISDLVEAMSQ 449
            ||:..|.:|:|:..|:.:|.|:.||...: |.:..:.:|..::::||||:.....:.:||::|..
Human   380 LREMMAKIEDKNEVLDQFMDSMQLDPETVDNLDAYSHIPPQLMEKCAALSVRPDTVRNLVQSMQV 444

  Fly   450 LAEITADVETNLGEISSMLEAEAKAEREFQSATG----VQRTPNAHITELSREFQKYSEAHARAG 510
            |:.:..|||.:|.:|..:||.:...|::||.|.|    :..|..|.:.|:.||:.||.|.|.:|.
Human   445 LSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQAGAISITSKAELAEVRREWAKYMEVHEKAS 509

  Fly   511 ESNNTLRKAMSLHVNNLKILARPLPEIQQLMPKLSSELNTTEIFRDVKLILNKVNEMKAQRAQFH 575
            .:|:.|.:||:|||.||::|:.||.:::..:|..:.......:.:::|.||.||.||:.||....
Human   510 FTNSELHRAMNLHVGNLRLLSGPLDQVRAALPTPALSPEDKAVLQNLKRILAKVQEMRDQRVSLE 574

  Fly   576 ADLRIAINEDDITGKVIAHGGQEGLQALFATELGKHDKITELLDQNMVAQGNILQALTENYAKAA 640
            ..||..|.:||||..::.....| ::.||..:|.|:|::...|:||:.||..:|.||||...:.|
Human   575 QQLRELIQKDDITASLVTTDHSE-MKKLFEEQLKKYDQLKVYLEQNLAAQDRVLCALTEANVQYA 638

  Fly   641 PVLKTLQDVKQKREHFYSSLAASYDVYEDLLAKSAKGLEFYKKLAGNVQKLLTRFRSARDVQSEE 705
            .|.:.|.|:.||......:|.|||:.||||:.||.:|.:||..|...|..||.|.:|....:...
Human   639 AVRRVLSDLDQKWNSTLQTLVASYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAREAA 703

  Fly   706 RQQ---RMQSVKAATTPVVSKPI----AETTPVPAVSSTPKLRDY---LKAKAAMAD----ASNP 756
            |||   |....|....|...||:    .|:..|.|.....:||..   :.|...:.|    ::.|
Human   704 RQQLLDRELKKKPPPRPTAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATP 768

  Fly   757 AYVPTVRPVPVGSENPTQAACSYATAPPNEPPPPYSLTQQQYFDPSAAG-YTNPMYQQQQQHIAP 820
            .:.|   |.|..|.  |.....|.:.|  .||..|| ...|...|.|.| :..|        :||
Human   769 LHFP---PSPFPSS--TGPGPHYLSGP--LPPGTYS-GPTQLIQPRAPGPHAMP--------VAP 817

  Fly   821 -------PAYKAQAS--PNSQTLHGALGQMNLQGQSQDNNQAGMAYNYGYPSGSVPPLA---YAP 873
                   |||..:..  |.|...||.:          .:...|:        |..||:|   .||
Human   818 GPALYPAPAYTPELGLVPRSSPQHGVV----------SSPYVGV--------GPAPPVAGLPSAP 864

  Fly   874 P----------GTVPASSASQGLNIQQPLYVATSGNPVSVSNPSELPSTLQAPFVVNPMSNPYQT 928
            |          ...||::....:....|.:.|...||    .|:..|.....| ...|:..||  
Human   865 PPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPNP----TPAPPPPCFPVP-PPQPLPTPY-- 922

  Fly   929 AAGYSGQAYQQVNAQAQQVTYPTAPSGSSTGQSAQQPLGYAPSQGPQQQAGGYPQSQTPQQQVGA 993
                               |||.         .|:||:   |:|  ...:.|.|           
Human   923 -------------------TYPA---------GAKQPI---PAQ--HHFSSGIP----------- 943

  Fly   994 YQQQPLSGY-AQQLTPQQQTGYSQSQAPQLQAPSYAQNQQSTGQAQQQQTGYPQTPQQHLAGYAQ 1057
                  :|: |.::.||                                      ||.|      
Human   944 ------AGFPAPRIGPQ--------------------------------------PQPH------ 958

  Fly  1058 SQQQATGYPQSQTSQQQTTGYSQSQTPQQPLAYQQQPSGYPQQQQQQSLAPQQPSLYPSQAVQAS 1122
                    ||...||.     ...|.|||||.. |.|..:|         ||.|.|.|.|    |
Human   959 --------PQPHPSQA-----FGPQPPQQPLPL-QHPHLFP---------PQAPGLLPPQ----S 996

  Fly  1123 PQPIPGQQATPPNAGQPLP--YPQQYTDPNAAPAPAPGVSSVPSPVPVPTPAPTSSQAQVPTSPH 1185
            |.|...|   |...|||.|  :.|.|..|...|.||..     ..:|.|:|.|       |..||
Human   997 PYPYAPQ---PGVLGQPPPPLHTQLYPGPAQDPLPAHS-----GALPFPSPGP-------PQPPH 1046

  Fly  1186 PSATYTSYSNHPGYSFNPQTGKYEYSSGYQQDTSSLKGSQASQSYQFSQSGKQQSVGTTDSEIAS 1250
            |...|     .|..|..|.                  |.||                        
Human  1047 PPLAY-----GPAPSTRPM------------------GPQA------------------------ 1064

  Fly  1251 RSNTATGFDSPIVSHTKVNMAAKDSTSAIEGNESSNYYSTPYGYLGSVNPQQQPTPAPPSNSTAS 1315
                     :|:               .|.|..|:. .|||       :|...|:|||       
Human  1065 ---------APL---------------TIRGPSSAG-QSTP-------SPHLVPSPAP------- 1090

  Fly  1316 IYMQSGASSTAETQTTSSGVPYASSAALTKVEPKPEALPP-----KVTSNVDLLSDLDIDCSVAV 1375
                                    |.....|.|:|.|..|     :..:..||||..........
Human  1091 ------------------------SPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGT 1131

  Fly  1376 PPPMLPQPVLQPQVVATPTPPASQVSVPVKVESVAEHAAPATAEIPVAATEGTAQTPVTIPSGPK 1440
            ..|...||:||                |.||:                |.||..         |:
Human  1132 QSPGGGQPLLQ----------------PTKVD----------------AAEGRR---------PQ 1155

  Fly  1441 CASLDNLSNCSDLSSLENFDWDSVSVTHSVSEKQTKASATANGHSSSFAFQSETFTDEKTTKYFQ 1505
            ...|                                             .:.:.:...:..:..|
Human  1156 ALRL---------------------------------------------IERDPYEHPERLRQLQ 1175

  Fly  1506 KEVESYEKLLENLHVKMLNGKTQLGAKWQELQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYD 1570
            :|:|::...|.::..        |...|:|||..  :|..|..||..||:.:..|||..|.:|||
Human  1176 QELEAFRGQLGDVGA--------LDTVWRELQDA--QEHDARGRSIAIARCYSLKNRHQDVMPYD 1230

  Fly  1571 HARVKLDKQTDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL- 1634
            ..||.|....||||||:.::.||..||..:..|.|.|.|..|||.|:..:|...:|.|.:..|: 
Human  1231 SNRVVLRSGKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEME 1295

  Fly  1635 ---FDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQL--KQWTK- 1693
               ...|:|....||..:...::....|:...  :..:..||:...|..|..||:.|  ..|.: 
Human  1296 KQKVARYFPTERGQPMVHGALSLALSSVRSTE--THVERVLSLQFRDQSLKRSLVHLHFPTWPEL 1358

  Fly  1694 ---GAPAQLLGVAENALETH----RQRCKAANAP-QSPLIMNCLTGSERSELVAIGVCAI--IAT 1748
               .:|:.||...:   |.|    .||      | .:|:|::|.:|..|:...|:...|:  :..
Human  1359 GLPDSPSNLLRFIQ---EVHAHYLHQR------PLHTPIIVHCSSGVGRTGAFALLYAAVQEVEA 1414

  Fly  1749 QNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLCNAHNVLNKRGIMTSYQMKMAPQVTA 1813
            .|..|.|...:   .|:..||::.|::...|....:.|:.:...||.:.|:....:    |..:|
Human  1415 GNGIPELPQLV---RRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQRHGVPPPCK----PLASA 1472

  Fly  1814 KEQQENKDPLNELD 1827
            ...|:|..|.:..|
Human  1473 SISQKNHLPQDSQD 1486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mopNP_648722.2 BRO1_HD-PTP_like 2..363 CDD:185762 145/365 (40%)
V_HD-PTP_like 368..702 CDD:185747 129/338 (38%)
Glutenin_hmw <795..1261 CDD:367362 100/491 (20%)
PHA03247 <1329..1443 CDD:223021 22/118 (19%)
PRK12323 <1378..1540 CDD:481241 22/161 (14%)
Y_phosphatase 1558..1788 CDD:459674 69/246 (28%)
PTPN23NP_056281.1 BRO1_HD-PTP_like 2..357 CDD:185762 145/365 (40%)
TPR 1 250..283 12/32 (38%)
V_HD-PTP_like 362..700 CDD:185747 129/338 (38%)
TPR 2 374..407 16/32 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 701..812 31/118 (26%)
PHA03247 <727..1083 CDD:223021 126/611 (21%)
His 770..1130 133/646 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 888..1151 107/547 (20%)
6 X 2 AA approximate tandem repeats of P-Q 953..964 7/62 (11%)
PTP-N23 1243..1447 CDD:350387 56/217 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1513..1636
Blue background indicates that the domain is not in the aligned region.

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