DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mop and SPAC2G11.05c

DIOPT Version :9

Sequence 1:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_593085.1	Gene:	SPAC2G11.05c / 2541947	PomBaseID:	SPAC2G11.05c	Length:	701	Species:	Schizosaccharomyces pombe

Alignment Length:	750	Identity:	146/750 - (19%)
Similarity:	254/750 - (33%)	Gaps:	202/750 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 YSKEVHALETLRNQ--AMHTTKDGAPVMKRYYCQLHALQNRFPQLADRGIFTFKWKDLYHSAVHE 103
            |..::...:.||:|  ..|.:.:.....:.|:..|..|:.:.   ....:..|.|.....|...|
pombe    34 YENDLKTFKALRSQLCLSHPSINSLSSFQTYHQLLCVLEQKH---LSECVAPFVWTLSSSSNERE 95

  Fly   104 -VTDLRFERAAVLFNIAALHTQSGASVTRGDVDGMKMACTHFQAAAWAYGELRERYANVNGGGDF 167
             ..:|.||.|.:::.:|..:..:..|:.......:..||.:||.:|..:     ||.|     ||
pombe    96 SFENLIFEHACLIYRLACTYHTTAISLCNEKPPNLVQACQYFQLSAGCF-----RYIN-----DF 150

  Fly   168 --------MTPELLVFQQQVCFAQAQECILEK-SLIDNRKPHIVAKVTAQIVVYYGAALAALLTG 223
                    ....||...:..|.|:||.||..| :..|.....|:.|:.|::.:.|..|. .|...
pombe   151 YIYTKSLDFNENLLKAWEIYCLAEAQTCIFSKANSNDTTSESIIVKILAKVFLLYEDAY-KLFKN 214

  Fly   224 GDDGPVAQVIDSSVYKLWKKYVRFKINYLTCILYLYQGQHSEEKRQMGERVTLYQASWDKLEEAR 288
            ....|       |::..| .|:: |:.|.| |.|....:.|....:.||.::..:.|....:||.
pombe   215 ATGAP-------SIFVHW-TYIQ-KLFYQT-ITYQIISRTSYSLNKYGENISYLRLSLLHCKEAL 269

  Fly   289 KESKGLPDQREINESLSFTADVVEAKRKNAKNENEFIYHE------AVPELSTIAAVQGANLVNG 347
            |.........::.|.|......::.:.|..:.:|:||:.:      :.|.|.|:..||...
pombe   270 KTRFDFGFNVKVYEKLEKLESSLQFELKRNERDNDFIHLQPEIPVGSFPLLDTVTMVQSIT---- 330

  Fly   348 IGFQVSDEEHAGPDIFARLVPMKAHEASSLYSEEKAKLLRKYGALLEEKDTQ-LESYMSSLTLDN 411
                        ||:..        :.::.|......|.:::..|:||.:.. |::.:.|:..
pombe   331 ------------PDVLT--------DKTAAYPYFSTCLDKEFMDLIEEHEKNILDAAVKSIDC-- 373

  Fly   412 LNINEEQANKLPQGIVDRCAALNANKTAISDLVEAMSQLAEITADVETNLGEISSMLEAEAKAER 476
              :.:|...|| ..:::...::|.|:.......:.|....||     .|||.: ..|.:||
pombe   374 --LTKEGTEKL-FALMEEIKSVNDNRYITETSNKVMENFTEI-----KNLGGL-EFLRSEA---- 425

  Fly   477 EFQSATGVQRTPNAHITELSREFQKYSEAHARAGESNNTLR---KAMSLHVNNLKILARPLPEIQ 538
                                      |.......:.|.|.|   :|:...:|::|        ..
pombe   426 --------------------------SSLDCLIDKVNGTYRHCCQALDEIINSVK--------SS 456

  Fly   539 QLMPKLSSELNTTEIFRDVKLILNKVNEMKAQRAQFHADLRIAINEDDITGKVIAHGGQEGLQAL 603
            |.|.:.....:..::..:|.|:  |||...:|.|           :|.|...:.|.|
pombe   457 QNMKEKGFYSDVIKLHEEVSLL--KVNVENSQNA-----------KDTIQKDISAFG-------- 500

  Fly   604 FATELGKHDKITELLDQNMVAQGNILQALTENYAKAAPVLKTLQDVKQKREHFYSSLAASYDVYE 668
                                      :.:.|..|::..:|..|.:.|..........|.||....
pombe   501 --------------------------KDIFELSAQSERILSNLAEKKNPNTDQLLLQANSYLAQW 539

  Fly   669 DLLAKSAKGLEFYKKLAGN-------------VQKLLTRFRSARDVQSEERQQR-MQSVKAATTP 719
            |||......|   |||..|             :..||..||.|.|.:...|:|| .|.:
pombe   540 DLLKDERNML---KKLGSNDYFNISMYSNHTDIHSLLKCFREAVDAKWNFRRQRERQEI------ 595

  Fly   720 VVSKPIAETTPVPAVSSTPKLRDYLKAKAAMADAS 754
                         .:.:..||:.||.:....|:.|
pombe   596 -------------IIQNVEKLKSYLNSFKVQAECS 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762	73/339 (22%)
		V_HD-PTP_like	368..702	CDD:185747	63/350 (18%)
		ALIX_LYPXL_bnd	421..699	CDD:290660	53/293 (18%)
		Med15	808..>1246	CDD:255446
		Y_phosphatase	1558..1788	CDD:278528
		PTPc	1559..1745	CDD:238006
SPAC2G11.05c	NP_593085.1	BRO1_ScRim20-like	2..354	CDD:185764	75/367 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23030
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R147
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940